Impact of Exercise on Immunometabolism in Multiple Sclerosis
Abstract
:1. Introduction
1.1. Immunopathology of Multiple Sclerosis
1.2. Exercise in Multiple Sclerosis
2. Exercise as a Regulator of Immunometabolism
2.1. Overview
2.2. Metabolic Pathways and Modulators Disrupted in MS
2.2.1. Glycolysis (Glucose Metabolism)
2.2.2. Fatty Acid Metabolism
2.2.3. Mitochondrial Oxidative Stress
2.2.4. Glutamine/Glutamate
2.2.5. mTOR and AMPK: Nutrient Sensing Pathways
2.2.6. Tryptophan/Kynurenine
3. Conclusions
4. Limitations
Author Contributions
Funding
Conflicts of Interest
References
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Metabolic Pathway | Pharmacological Drugs | Exercise Therapy | |||
---|---|---|---|---|---|
Drug | Effect | REF(S) | Effect | REF(S) | |
Glycolysis | DMF | ↓ Glycolysis Enzyme GAPDH In Myeloid and Lymphoid Cells | [69] | ↓ Glycolysis ↑ Glucose Tolerance | [70,72,73,174] |
Fatty Acid Metabolism | Natalizumab | ↓ Inflammatory Oxysterol 24S-OH In CSF | [80] | ↑ FAO ↓ Cholesterol LDL Synthesis | [92,95,97,98] |
Mitochondrial Oxidative Stress | DMF | ↓ Ros ↑ Nrf2 Antioxidant Response Pathway | [175] | ↓ Ros ↑ Pgc1α ↑ Antioxidant Response | [22,113,121,122] |
Glutamate | Memantine | ↓ Glutamate Excitotoxicity | [130] | ↓ Glutamate by Increasing Glutamate Uptake and Metabolism | [136,176] |
mTOR/AMPK | Temsirolimus | ↓ mTOR Activity | [154] | ↓ mTOR ↑ AMPK | [95,151] |
Kynurenine | IFN-β | ↑ Kyn/Trp Ratio | [165] | ↑ KynA (due to ↑ PGC-1α) | [155,171] |
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Afzal, R.; Dowling, J.K.; McCoy, C.E. Impact of Exercise on Immunometabolism in Multiple Sclerosis. J. Clin. Med. 2020, 9, 3038. https://doi.org/10.3390/jcm9093038
Afzal R, Dowling JK, McCoy CE. Impact of Exercise on Immunometabolism in Multiple Sclerosis. Journal of Clinical Medicine. 2020; 9(9):3038. https://doi.org/10.3390/jcm9093038
Chicago/Turabian StyleAfzal, Remsha, Jennifer K Dowling, and Claire E McCoy. 2020. "Impact of Exercise on Immunometabolism in Multiple Sclerosis" Journal of Clinical Medicine 9, no. 9: 3038. https://doi.org/10.3390/jcm9093038