Clinical Characteristics, Treatments, and Outcomes of Patients with Myocardial Infarction with Non-Obstructive Coronary Arteries (MINOCA): Results from a Multicenter National Registry
Abstract
:1. Introduction
2. Methods
2.1. Data Sources
2.2. Study Population
2.3. Statistical Analysis
3. Results
4. Discussion
Study Limitations
5. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
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CAD | I20, I21, I25 |
HF and Cardiomyopathies (%) | I42, I43, I50 |
Arrythmias (%) | I44, I45, I47, I48, I50 |
Cerebrovascular Disease (%) | I60, I61, I62, I63, I64, I65, I66, I67, I68, I69 |
Hypertension (%) | I10, I11, I12, I13, I14, I15 |
Valvular Disease and Infective Endocarditis (%) | I05, I06, I07, I08, I09, I35, I36, I37, I38, I39 |
Disease of Arteries, Arterioles and Capillaries (%) | I70, I71, I72, I73, I74, I75, I76, I77, I78, I79 |
Other | I26, I27, I28, I30, I31, I32, I40, I41, I51, I52, I80, I81, I82, I83, I84, I5, I86, I87, I88, I89, I90, I91, I92, I93, I94, I95, I96, I97, I98, I99 |
Variable | MINOCA n = 6063 | MI-CAD n = 160,886 | p Value |
---|---|---|---|
Age (years (Q1–Q3)) | 67 (58–77) | 65 (57–75) | <0.001 |
Female (%) | 53.11 | 34.44 | <0.001 |
STEMI (%) | 16.55 | 49.09 | <0.001 |
Dominant Symptom | |||
Angina (%) | 88.32 | 94.24 | <0.001 |
Dyspnoea (%) | 5.76 | 2.38 | |
Syncope (%) | 1.40 | 0.53 | <0.001 |
Fatigue (%) | 1.09 | 0.69 | <0.001 |
SBP (mmHg (Q1–Q3)) | 130 (110–150) | 130 (110–150) | 0.750 |
DBP (mmHg (Q1–Q3)) | 80 (75–100) | 80 (75–100) | 0.080 |
HR (1/min (Q1–Q3)) | 76 (70–90) | 75 (68–85) | <0.001 |
LVEF (% (Q1–Q3)) | 50 (44.5–60) | 50 (40–55) | <0.001 |
Heart Failure | |||
NYHA I (%) | 62.56 | 62.54 | 0.730 |
NYHA II (%) | 30.84 | 31.50 | 0.410 |
NYHA III (%) | 4.43 | 3.89 | 0.042 |
NYHA IV (%) | 1.81 | 2.07 | 0.210 |
Hypertension (%) | 73.91 | 73.39 | 0.520 |
Hypercholesterolaemia (%) | 35.85 | 44.19 | <0.001 |
Smoking (%) | 47.35 | 59.42 | <0.001 |
Diabetes (%) | 22.46 | 25.86 | <0.001 |
Obestiy (%) | 18.23 | 20.31 | <0.001 |
Previous CAD (%) | 7.27 | 13.93 | <0.001 |
Previous PCI (%) | 0 | 13.71 | <0.001 |
Previous MI (%) | 0 | 18.00 | <0.001 |
Previous CABG (%) | 0 | 3.91 | <0.001 |
Previous stroke (%) | 3.26 | 3.58 | 0.500 |
Previous kidney disease (%) | 5.51 | 5.88 | 0.700 |
Previous lung disease (%) | 4.42 | 3.68 | 0.009 |
Previous PAD | 3.94 | 4.76 | 0.033 |
Sinus rhythm in ECG (%) | 86.38 | 92.77 | <0.001 |
Atrial fibrillation in ECG (%) | 9.75 | 5.31 | <0.001 |
Rhythm from pacemaker in ECG (%) | 1.11 | 0.61 | <0.001 |
Variable | MINOCA n = 6063 | MI-CAD n = 160,866 | p Value |
---|---|---|---|
Aspirin (%) | 87.68 | 92.45 | <0.001 |
P2Y12 inhibitors (%) | 67.58 | 84.80 | <0.001 |
ACE inhibitors (%) | 74.01 | 79.39 | <0.001 |
Beta-adrenolytics (%) | 78.60 | 84.36 | <0.001 |
Statins (%) | 83.38 | 88.99 | <0.001 |
Nitrates (%) | 9.09 | 12.44 | <0.001 |
LMWH (%) | 4.25 | 4.52 | 0.41 |
Oral anticoagulants (%) | 5.89 | 2.18 | <0.001 |
Variable | MINOCA n = 6063 | MI-CAD n = 160,866 | p Value |
---|---|---|---|
In-Hospital | |||
Cardiac arrest (%) | 0.90 | 1.92 | <0.001 |
Pulmonary edema (%) | 0.25 | 0.58 | 0.002 |
Cardiogenic shock (%) | 0.36 | 0.90 | <0.001 |
Myocardial infarction (%) | 0.06 | 0.38 | 0.004 |
Death (%) | 1.67 | 2.08 | 0.004 |
Cardiovascular death (%) | 1.99 | 1.48 | 0.006 |
Stroke | 0.21 | 0.15 | 0.290 |
12 Months | |||
Myocardial infarction (%) | 3.83 | 7.26 | <0.001 |
Death (%) | 10.94 | 9.54 | <0.001 |
Stroke (%) | 1.83 | 1.50 | 0.039 |
Coronarography (%) | 6.93 | 26.02 | <0.001 |
PCI (%) | 4.37 | 20.33 | <0.001 |
CABG (%) | 3.10 | 5.48 | <0.001 |
Cardiac ablation (%) | 0.96 | 0.18 | <0.001 |
ICD/CRT-D implantation (%) | 1.30 | 18.15 | <0.001 |
36 Months | |||
Myocardial infarction (%) | 6.19 | 10.11 | <0.001 |
Death (%) | 16.18 | 14.93 | 0.081 |
Stroke (%) | 3.10 | 2.64 | 0.030 |
Coronarography (%) | 9.88 | 31.15 | <0.001 |
PCI (%) | 5.82 | 23.90 | <0.001 |
CABG (%) | 3.22 | 6.04 | <0.001 |
Cardiac ablation (%) | 1.32 | 0.29 | <0.001 |
ICD /CRT-D implantation (%) | 1.65 | 18.89 | <0.001 |
Variable | MINOCA n = 6063 | MI-CAD n = 160,886 | p Value |
---|---|---|---|
12 Months | |||
All cause readmission (%) | 45.19 | 54.33 | <0.001 |
Cardiovascular readmission (%) | 31.30 | 43.62 | <0.001 |
CAD (%) | 45.27 | 73.23 | <0.001 |
CCS (%) | 25.91 | 45.63 | <0.001 |
UA (%) | 10.92 | 20.29 | <0.001 |
STEMI (%) | 3.97 | 3.78 | 0.840 |
NSTEMI (%) | 4.47 | 3.53 | 0.110 |
HF and Cardiomyopathies (%) | 17.93 | 9.80 | <0.001 |
Arrythmias (%) | 14.01 | 4.08 | <0.001 |
Cerebrovascular disease (%) | 5.34 | 2.40 | <0.001 |
Hypertension (%) | 5.24 | 2.26 | <0.001 |
Valvular disease and infective endocarditis (%) | 5.02 | 1.01 | <0.001 |
Disease of arteries, arterioles and capillaries (%) | 3.65 | 2.33 | 0.001 |
Difference | 6.54 | 4.88 | 0.001 |
36 Months | |||
All cause readmission (%) | 56.42 | 66.66 | <0.001 |
Cardiovascular readmission (%) | 39.19 | 52.13 | <0.001 |
CAD (%) | 44.66 | 69.59 | <0.001 |
CCS (%) | 24.46 | 41.99 | <0.001 |
UA (%) | 10.54 | 19.89 | <0.001 |
STEMI (%) | 4.52 | 4.42 | 0.890 |
NSTEMI (%) | 5.14 | 3.80 | 0.026 |
HF and Cardiomyopathies (%) | 17.59 | 10.31 | <0.001 |
Arrythmias (%) | 13.92 | 4.33 | <0.001 |
Cerebrovascular disease (%) | 5.94 | 3.25 | <0.001 |
Hypertension (%) | 6.19 | 2.71 | <0.001 |
Valvular disease and infective endocarditis (%) | 4.78 | 1.04 | <0.001 |
Disease of arteries, arterioles and capillaries (%) | 3.67 | 2.83 | 0.050 |
Difference | 3.25 | 5.33 | <0.001 |
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Gasior, P.; Desperak, A.; Gierlotka, M.; Milewski, K.; Wita, K.; Kalarus, Z.; Fluder, J.; Kazmierski, M.; Buszman, P.E.; Gasior, M.; et al. Clinical Characteristics, Treatments, and Outcomes of Patients with Myocardial Infarction with Non-Obstructive Coronary Arteries (MINOCA): Results from a Multicenter National Registry. J. Clin. Med. 2020, 9, 2779. https://doi.org/10.3390/jcm9092779
Gasior P, Desperak A, Gierlotka M, Milewski K, Wita K, Kalarus Z, Fluder J, Kazmierski M, Buszman PE, Gasior M, et al. Clinical Characteristics, Treatments, and Outcomes of Patients with Myocardial Infarction with Non-Obstructive Coronary Arteries (MINOCA): Results from a Multicenter National Registry. Journal of Clinical Medicine. 2020; 9(9):2779. https://doi.org/10.3390/jcm9092779
Chicago/Turabian StyleGasior, Pawel, Aneta Desperak, Marek Gierlotka, Krzysztof Milewski, Krystian Wita, Zbigniew Kalarus, Joanna Fluder, Maciej Kazmierski, Paweł E. Buszman, Mariusz Gasior, and et al. 2020. "Clinical Characteristics, Treatments, and Outcomes of Patients with Myocardial Infarction with Non-Obstructive Coronary Arteries (MINOCA): Results from a Multicenter National Registry" Journal of Clinical Medicine 9, no. 9: 2779. https://doi.org/10.3390/jcm9092779