Altered GH-IGF-1 Axis in Severe Obese Subjects is Reversed after Bariatric Surgery-Induced Weight Loss and Related with Low-Grade Chronic Inflammation
Abstract
:1. Introduction
2. Patients and Methods
2.1. Patients and Controls
2.2. Parameters Analyzed
2.3. Analytical Procedures
2.4. Calculations
2.5. Statistical Analysis
3. Results
3.1. Characteristics of the Obese Patients and the Control Group
3.2. Fasting Serum Levels
3.3. Time Course of the Clinical and Analytical Parameters
4. Discussion
5. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
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Control Subjects | Obese Subjects | p | |
---|---|---|---|
Median (IR) | Median (IR) | ||
Age (years) | 42.0 (37.3; 53.0) | 45.2 (39.1; 50.8) | 0.794 |
Sex (n, %) | 0.143 | ||
Female | 73.2% | 83.6% | |
Male | 26.8% | 16.4% | |
BMI (kg/m2) | 23.2 (21.1; 24.1) | 47.8 (43.8; 53.0) | <0.001 |
Body fat (%) | 27.6 (20.5; 30.4) | 51.1 (48.0; 54.2) | <0.001 |
Type of surgery (%) | --- | ||
Roux-en-Y gastric bypass | 50.9% | ||
Sleeve gastrectomy | 49.1% |
Control Subjects | Obese Subjects | p | |
---|---|---|---|
Median (IR) | Median (IR) | ||
IGF-1 (µg/L) | 138.0 (111; 174) | 79.5 (56.6; 95.0) | <0.001 |
GH (µg/L) | 0.5 (0.2; 1.7) | 0.3 (0.1; 0.8) | 0.087 |
TSH (µU/mL) | 1.9 (1.3; 2.5) | 2.8 (1.5; 4.9) | 0.002 |
Free T4 (ng/dL) | 1.2 (1.1; 1.2) | 1.4 (1.3; 1.7) | <0.001 |
Fasting Glucose (mg/dL) | 89.0 (84.0; 95.0) | 96.0 (81.5; 115.5) | 0.030 |
Fasting Insulin (µIU/mL) | 3.5 (2.9; 6,2) | 6.0 (2.8; 9.6) | 0.009 |
HOMA-IR | 0.8 (0.6; 1.5) | 1.4 (0.6; 2.7) | 0.004 |
Obese Patients Before Surgery | Obese Patients Twelve Months after Surgery | Change | p | |
---|---|---|---|---|
Median (IR) | Median (IR) | Median (IR) | ||
IGF-1 (µg/L) | 79.5 (56.6; 95.0) | 110.5 (88.0; 129.5) | −30.5 (−52.0; −11.0) | <0.001 |
GH (µg/L) | 0.3 (0.1; 0.8) | 2.1 (0.3; 4.8) | −2.0 (−3.6; −0.1) | <0.001 |
Weight (kg) | 123.1 (105.4; 146.0) | 83.5 (69.5; 98.0) | 43.1 (36.7; 55.3) | <0.001 |
BMI (kg/m2) | 47.8 (43.8; 53.0) | 30.4 (26.9; 35.6) | 16.5 (13.8; 19.5) | <0.001 |
Body fat (%) | 51.1 (48.0; 54.2) | 33.0 (25.7; 40.8) | 16.7 (11.2; 20.3) | <0.001 |
TSH (µU/mL) | 2.8 (1.5; 4.9) | 2.3 (1.4; 3.2) | 0.7 (−0.4; 2.5) | 0.001 |
Free T4 (ng/dL) | 1.4 (1.3; 1.7) | 1.1 (1.0; 1.2) | 0.3 (0.2; 0.6) | <0.001 |
Fasting Glucose (mg/dL) | 96.0 (81.5; 115.5) | 84.0 (77.0; 90.0) | 12.0 (−2.0; 26.5) | <0.001 |
Fasting Insulin (µIU/mL) | 6.0 (2.8; 9.6) | 5.4 (2.9; 8.5) | 0.3 (−1.8; 3.4) | 0.256 |
HOMA-IR | 1.4 (0.6; 2.7) | 1.1 (0.6; 2.0) | 0.3 (−0.4; 1.0) | 0.037 |
C-Peptide (ng/mL) | 2.1 (1.4; 3.2) | 1.8 (1.4; 2.3) | 0.1 (−0.6; 1.0) | 0.194 |
C-Reactive Protein (mg/dL) | 0.7 (0.4; 1.2) | 0.1 (0.02; 0.3) | 0.5 (0.1; 0.8) | <0.001 |
IGF-1 | GH | |||||
---|---|---|---|---|---|---|
B | SE | p | B | SE | p | |
Intercept | 113.25 | 18.67 | <0.001 | 2.06 | 1.06 | 0.052 |
Linear time (months after surgery) | 1.91 | 0.43 | <0.001 | 0.21 | 0.04 | <0.001 |
Basal BMI (kg/m2) | −0.58 | 0.33 | 0.083 | −0.01 | 0.02 | 0.679 |
Free T4 (ng/dL) | 3.15 | 5.34 | 0.555 | −0.62 | 0.31 | 0.045 |
C-Reactive Protein (mg/dL) | −12.29 | 3.23 | <0.001 | 0.01 | 0.20 | 0.997 |
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Juiz-Valiña, P.; Pena-Bello, L.; Cordido, M.; Outeiriño-Blanco, E.; Pértega, S.; Varela-Rodriguez, B.; Garcia-Brao, M.J.; Mena, E.; Sangiao-Alvarellos, S.; Cordido, F. Altered GH-IGF-1 Axis in Severe Obese Subjects is Reversed after Bariatric Surgery-Induced Weight Loss and Related with Low-Grade Chronic Inflammation. J. Clin. Med. 2020, 9, 2614. https://doi.org/10.3390/jcm9082614
Juiz-Valiña P, Pena-Bello L, Cordido M, Outeiriño-Blanco E, Pértega S, Varela-Rodriguez B, Garcia-Brao MJ, Mena E, Sangiao-Alvarellos S, Cordido F. Altered GH-IGF-1 Axis in Severe Obese Subjects is Reversed after Bariatric Surgery-Induced Weight Loss and Related with Low-Grade Chronic Inflammation. Journal of Clinical Medicine. 2020; 9(8):2614. https://doi.org/10.3390/jcm9082614
Chicago/Turabian StyleJuiz-Valiña, Paula, Lara Pena-Bello, Maria Cordido, Elena Outeiriño-Blanco, Sonia Pértega, Barbara Varela-Rodriguez, Maria Jesus Garcia-Brao, Enrique Mena, Susana Sangiao-Alvarellos, and Fernando Cordido. 2020. "Altered GH-IGF-1 Axis in Severe Obese Subjects is Reversed after Bariatric Surgery-Induced Weight Loss and Related with Low-Grade Chronic Inflammation" Journal of Clinical Medicine 9, no. 8: 2614. https://doi.org/10.3390/jcm9082614