Rheumatoid Arthritis Treatment. A Back to the Drawing Board Project or High Expectations for Low Unmet Needs?

Round 1

Reviewer 1 Report

Good, and well-written, publication on the unmet needs that emphasizes the need to study the patient well before prescribing the therapy in order to minimize what are currently the unmet needs of rheumatoid arthritis.

The publication is of a good standard and the subject is extremely interesting and topical. This publication could be a stimulus for future publications in order to solve the unmet needs on rheumatoid arthritis and optimize therapy for the individual patient.

Reviewer 2 Report

This Viewpoint manuscript proposes approaches all the rheumatologists should do to the treatment of rheumatoid arthritis. In particular, combinations of different therapeutic modality would increase the rate of responding patients. Developing new drags is important, but optimising current available treatments and taking newly developed drugs into the combination modality would be very important.

The paper is well written. This is very relevant and interesting article.  The text is clear and easy to read,  I enjoyed reading this article. This is original pitting several reports together and provide such an opinion. This is an important angle to improve patients treatment. It is unique and important. The conclusions are consistent with the evidence and arguments presented, and they address the main question posed.

Reviewer 3 Report

The article briefly addresses the dilemmas associated with modern approaches to rheumatoid arthritis therapy.

I believe that the paper is interesting. Rheumatoid arthritis is a severe, chronic, fairly common disease affecting approximately 1% of the general population. The paper briefly describes modern treatment options for rheumatoid arthritis. The authors present achievable treatment effects, which are not always remission of the disease.
The article is well written, read with pleasure. The authors pose many questions that are very important in everyday clinical practice and that require clarification in subsequent studies.