A Novel Frailty Score Based on Laboratory Parameters (FIMS Score) for the Management of Older Patients with Severe Aortic Stenosis
Abstract
:1. Introduction
2. Methods
2.1. Study Population
2.2. Statistical Analysis
3. Results
3.1. Characteristics of the Study Population
3.2. FIMS Score and Correlation
3.3. FIMS Score, Frailty, and Multidimensional Geriatric Assessment
3.4. FIMS Score as a Predictor of Mortality
4. Discussion
5. Limitations
6. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Sarcopenia | |||||
---|---|---|---|---|---|
Total (N = 109) | Yes (N = 54) | No (N = 55) | p-Value | ||
Age | Mean; Sd | 83.33 (5.5) | 83.8 (6.3) | 82.9 (4.6) | 0.420 |
Gender | Female | 67.9% | 72.2% | 63.6% | 0.337 |
Male | 32.1% | 27.8% | 36.4% | ||
Fried frailty phenotype | Pre-frail | 41.3% | 13.0% | 69.1% | 0.0001 |
Early-frail | 31.2% | 31.5% | 30.9% | ||
Frail | 27.5% | 55.5% | 0.0% | ||
Treatment classes | Surgical aortic valve replacement (SAVR) | 7.3% | 0.0% | 14.5% | 0.0001 |
Medical therapy (MT) | 13.8% | 25.9% | 1.8% | ||
Balloon aortic valvuloplasty (BAV) | 24.8% | 40.8% | 9.1% | ||
Valve replacement (TAVR) | 54.1% | 33.3% | 74.6% |
Sarcopenia | p-Value | ||||
---|---|---|---|---|---|
Yes (N = 54) | No (N = 55) | ||||
Mean | Sd | Mean | Sd | ||
Haemoglobin (Hb), g/dL | 12.12 | 1.8 | 12.64 | 1.5 | 0.112 |
Neutrophils, n/µL | 5588.52 | 2202.2 | 4560.00 | 1614.4 | 0.006 |
Lymphocytes, n/µL | 1712.26 | 1005.7 | 1871.38 | 851.3 | 0.374 |
Monocytes, n/µL | 662.22 | 211.6 | 626.36 | 213.0 | 0.406 |
C-reactive protein (CRP), mg/dL | 0.95 | 1.9 | 0.54 | 0.9 | 0.161 |
Total cholesterol, mg/dL | 182.50 | 28.9 | 187.74 | 41.7 | 0.457 |
Uricemia, mg/dL | 6.26 | 2.1 | 5.90 | 1.7 | 0.380 |
Creatinine, mg/dL | 1.62 | 1.6 | 1.08 | 0.3 | 0.015 |
Mean Platelet Volume (MPV), fl | 10.83 | 0.9 | 10.69 | 0.8 | 0.401 |
Haematocrit (HCT), % | 37.36 | 5.2 | 38.45 | 4.2 | 0.233 |
Creatine phosphokinase (CPK), IU/L | 57.34 | 27.9 | 80.80 | 40.7 | 0.001 |
Troponin I, µg/L | 0.04 | 0.0 | 0.02 | 0.0 | 0.027 |
Gamma-Glutamyl Transferase (GGT), IU/L | 29.75 | 37.4 | 33.19 | 35.7 | 0.630 |
Thyroid-Stimulating Hormone (TSH), mU/L | 1.78 | 1.1 | 3.17 | 9.8 | 0.306 |
High-Density Lipoprotein cholesterol (HDL), mg/dL | 54.06 | 17.9 | 58.13 | 13.2 | 0.190 |
Low-Density Lipoprotein Cholesterol (LDL), mg/dL | 107.73 | 26.6 | 105.94 | 33.7 | 0.768 |
B-type natriuretic pepetide (BNP), mg/L | 746.17 | 1227.7 | 367.37 | 497.8 | 0.048 |
Albumin, g/dL | 3.91 | 0.5 | 4.11 | 0.4 | 0.020 |
Variables | FIMS Score | |
---|---|---|
r | p-Value | |
Instrumental Activities of Daily Living (IADL) | −0.33 | <0.0001 |
Basic Activities of Daily Living (BADL) | −0.279 | 0.003 |
Mini Nutritional Assessment (MNA) | −0.316 | 0.001 |
Mini Mental State Examination (MMSE) | −0.47 | 0.6 |
Charlson Comorbidity index | 0.371 | <0.0001 |
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Esposito, A.; Foffa, I.; Bastiani, L.; Vecoli, C.; Rizza, A.; Storti, S.; De Caterina, A.R.; Mazzone, A.; Berti, S. A Novel Frailty Score Based on Laboratory Parameters (FIMS Score) for the Management of Older Patients with Severe Aortic Stenosis. J. Clin. Med. 2023, 12, 5927. https://doi.org/10.3390/jcm12185927
Esposito A, Foffa I, Bastiani L, Vecoli C, Rizza A, Storti S, De Caterina AR, Mazzone A, Berti S. A Novel Frailty Score Based on Laboratory Parameters (FIMS Score) for the Management of Older Patients with Severe Aortic Stenosis. Journal of Clinical Medicine. 2023; 12(18):5927. https://doi.org/10.3390/jcm12185927
Chicago/Turabian StyleEsposito, Augusto, Ilenia Foffa, Luca Bastiani, Cecilia Vecoli, Antonio Rizza, Simona Storti, Alberto Ranieri De Caterina, Annamaria Mazzone, and Sergio Berti. 2023. "A Novel Frailty Score Based on Laboratory Parameters (FIMS Score) for the Management of Older Patients with Severe Aortic Stenosis" Journal of Clinical Medicine 12, no. 18: 5927. https://doi.org/10.3390/jcm12185927