Root Canal Infection and Its Impact on the Oral Cavity Microenvironment in the Context of Immune System Disorders in Selected Diseases: A Narrative Review
Abstract
:1. Introduction
2. Differentiation of Root Canals and Their Participation in Signaling Pathways
2.1. Differentiation of Root Canals
2.2. Communication Pathways between the Pulp and Periodontal Tissues
3. Interactions between the Immune System and Root Canals
3.1. Chronic Apical Periodontitis
3.2. Acute Apical Abscess
4. The Spread of Endodontic Bacteria to Adjacent Tissues and Organs, or How Systemic Infections and the Development of Autoimmune Diseases Occur
4.1. Periapical Inflammatory Lesions and Root Infections with Systemic Health
4.2. The Role of Root Canal Infection in the Pathogenesis of Autoimmune Diseases
4.2.1. Systemic Lupus Erythematosus and Periodontal Disease
4.2.2. Rheumatoid Arthritis and Periodontal Disease
4.2.3. Sjögren’s Syndrome (SS) and Periodontal Disease
4.2.4. Chronic Kidney Disease (CKD) and Periodontal Disease
4.2.5. Potential Pathogenic Link between Periodontal Disease and Inflammatory Bowel Disease
4.3. Instrumentation and Irrigation Solutions Manage Endodontic Infections
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Conflicts of Interest
Abbreviations
ANCA | Antineutrophil cytoplasmic antibody |
CCP | Cyclic citrullinated peptide |
CD | Crohn’s disease |
CKD | Chronic kidney disease |
DAMPs | Damage-associated molecular patterns |
GFR | Glomerular filtration rate |
LTA | Lipoteichoic acid |
MAPK | Mitogen-activated protein kinase |
M-CSF | Macrophage colony-stimulating factor |
NALP3 | NLR family pyrin domain containing 3 |
NF-κB | Nuclear factor kappa-light-chain-enhancer of activated B cells |
NLRs | NOD-like receptors |
NOD | Nucleotide-binding oligomerization domain containing |
PAMP | Pathogen-associated molecular patterns |
PRRs | Pattern recognition receptors |
RA | Rheumatoid arthritis |
RANKL | Receptor Activator for Nuclear Factor κ B Ligand |
SLE | Systemic Lupus Erythematosus |
SS | Sjögren’s syndrome |
TLR | Toll-like receptor |
TLRs | Toll-like receptors |
TNF-α | Tumor necrosis factor α |
UC | Ulcerative colitis |
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Type | Characteristic |
---|---|
Type 1 | Patent accessory canals that communicate with the periodontium and pulpal chamber—‘real canal.’ |
Type 2 | Accessory canals that start in the pulp chamber and end in dentine—‘blind pulp chamber canals.’ |
Type 3 | Accessory canals that start in the periodontium and end in dentine—‘blind periodontal canals.’ |
Type 4 | Accessory canals that start in the pulp chamber, go through dentine, and return to the pulp chamber—‘loop pulp chamber canals.’ |
Type 5 | Accessory canals originating from the periodontium, go through dentine and cementum, and return to the periodontium—‘loop periodontal canals.’ |
Type 6 | Accessory canals found in dentine and cementum, but with no exit—‘sealed dentine canals.’ |
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Sobieszczański, J.; Mertowski, S.; Sarna-Boś, K.; Stachurski, P.; Grywalska, E.; Chałas, R. Root Canal Infection and Its Impact on the Oral Cavity Microenvironment in the Context of Immune System Disorders in Selected Diseases: A Narrative Review. J. Clin. Med. 2023, 12, 4102. https://doi.org/10.3390/jcm12124102
Sobieszczański J, Mertowski S, Sarna-Boś K, Stachurski P, Grywalska E, Chałas R. Root Canal Infection and Its Impact on the Oral Cavity Microenvironment in the Context of Immune System Disorders in Selected Diseases: A Narrative Review. Journal of Clinical Medicine. 2023; 12(12):4102. https://doi.org/10.3390/jcm12124102
Chicago/Turabian StyleSobieszczański, Jarosław, Sebastian Mertowski, Katarzyna Sarna-Boś, Piotr Stachurski, Ewelina Grywalska, and Renata Chałas. 2023. "Root Canal Infection and Its Impact on the Oral Cavity Microenvironment in the Context of Immune System Disorders in Selected Diseases: A Narrative Review" Journal of Clinical Medicine 12, no. 12: 4102. https://doi.org/10.3390/jcm12124102