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Article
Peer-Review Record

Perioperative Radiographic Predictors of Non-Union in Infra-Isthmal Femoral Shaft Fractures after Antegrade Intramedullary Nailing: A Case–Control Study

J. Clin. Med. 2022, 11(13), 3664; https://doi.org/10.3390/jcm11133664
by Wei-Cheng Hung 1,†, Chin-Jung Hsu 1,2,†, Abhishek Kumar 1,3, Chun-Hao Tsai 1,4, Hao-Wei Chang 1 and Tsung-Li Lin 1,4,5,*
Reviewer 1:
Reviewer 2:
J. Clin. Med. 2022, 11(13), 3664; https://doi.org/10.3390/jcm11133664
Submission received: 1 June 2022 / Revised: 18 June 2022 / Accepted: 22 June 2022 / Published: 24 June 2022

Round 1

Reviewer 1 Report

THank you for allowing me to review your paper.

I think it is well-written and a well-performed study. This study investigates potential radiographic predictors of non union after diaphyseal femur fractures treated with antegrade IM nails.

They found a non union rate of around thirty percent and were able to identify severel risk factors for non-union.

This study is innovative as to the authors knowledge there are no other studies on this subject. Furthermore, reseach design, statistics and discussion are well-written and thorough.

 

 

Author Response

Point 1: Thank you for allowing me to review your paper.

I think it is well-written and a well-performed study. This study investigates potential radiographic predictors of non union after diaphyseal femur fractures treated with antegrade IM nails.

They found a non union rate of around thirty percent and were able to identify several risk factors for non-union.

This study is innovative as to the authors knowledge there are no other studies on this subject. Furthermore, research design, statistics and discussion are well-written and thorough.

Response 1: Thank you for your comment.

Reviewer 2 Report

This is a well designed study, however I believe a few more data points are necessary to be optimal for publication.  A known risk factor for non-union is the ratio of the IM canal to nail size at the level of the fracture.  The authors note this in the discussion.  This should be included to optimize the information of the study.

An additional citation to consider: 

Auston D, Donohue D, Stoops K, Cox J, Diaz M, Santoni B, Mir H. Long Segment Blocking Screws Increase the Stability of Retrograde Nail Fixation in Geriatric Supracondylar Femur Fractures: Eliminating the "Bell-Clapper Effect". J Orthop Trauma. 2018 Nov;32(11):559-564. doi: 10.1097/BOT.0000000000001284. PMID: 30086037.

Line 22: This is a confusing line.  I suggest - 93 patients were included, 31 nonunions and 62 case matched controls.

Introduction: Clarify early in the intro that antegrade nailing is being discussed. 

Materials and Methods: It would be more clear to use wording along the following lines - 31 cases of nonunion were identified (through coding/record search, etc).  62 matched controls were then identified (through coding/record search,etc).   The reader should be able to reproduce the study using your methods description.

Results and conclusions are sound, but would be improved by addition of data points re: intramedullary canal/nail ratio.

 

Author Response

Please see the attachment.

Author Response File: Author Response.pdf

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