Lipid Peroxidation Levels in Saliva and Plasma of Patients Suffering from Periodontitis
, Milanko Djuric 1,2, Jelena Mirnic 1, Ivana Gusic 1,2, Aleksandra Maletin 1, Bojana Ramic 1, Isidora Neskovic 1,2, Karolina Vukoje 1 and Snezana Brkic 1,3
Round 1
Reviewer 1 Report
The topic is interesting for a worldwide medical and dentist. This is an interesting work. However, to my understanding, some major methodological and statistical issues could bias and not address the objective.
1 How to determine the sample size？
2 It should give some reason of setting the age of included subjects were 30-70 years old.
3 Periodontal status should be defined by the 2018 classification scheme in the group of patients with periodontal disease.
4 Gingival crevicular fluid samples would be more likely to reflect periodontal inflammation and damage to periodontal tissues than salivary samples.
5 In view of the possible impact of smoking, study subjects who smoked cigarettes should be excluded.
6 Multi-factor-analysis after adjusting the confounding factors should be made to shows the real association between MDA levels in saliva and plasma in periodontitis patients.
7 The difference between two subgroups should be added.
Reviewer 2 Report
Dear authors,
Below are my comments regarding your submitted article.
- I would recommend reorganizing the abstract to be more concise.
- I think that at the end of the introduction section would be appropriate to be specified the aim of the study, not only the objectives.
- I would suggest the rephrasing of the conclusion to be more eloquent.
- I would also suggest reconsidering the Reference section since some cited articles are quite old (2001, 2002).
This manuscript is a resubmission of an earlier submission. The following is a list of the peer review reports and author responses from that submission.
