Association between Intra-Arrest Blood Glucose Level and Outcomes of Resuscitation at the Emergency Department: A Retrospective Study
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Design and Setting
2.2. Participants
2.3. Data Collection and Outcome Measures
2.4. Statistical Analysis
3. Results
3.1. Participants
3.2. Outcomes
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Variables | All Patients (n = 385) | Intra-Arrest BG < 70 mg/dL (n = 64) | Intra-Arrest BG 70–99 mg/dL (n = 34) | Intra-Arrest BG 100–180 mg/dL (n = 148) | Intra-Arrest BG 181–250 mg/dL (n = 66) | Intra-Arrest BG > 250 mg/dL (n = 73) | p-Value |
---|---|---|---|---|---|---|---|
Age, year (SD) | 60.4 (20.7) | 61.5 (20.7) | 53.0 (21.1) | 61.6 (21.7) | 63.7 (21.2) | 57.2 (17.2) | 0.27 |
Male, n (%) | 236 (61.3) | 32 (50.0) | 23 (67.7) | 94 (63.5) | 42 (63.6) | 45 (61.6) | 0.35 |
Time of arrival at ED, n (%) | 0.26 | ||||||
8.01–16.00 | 139 (36.1) | 29 (45.3) | 15 (44.1) | 54 (36.5) | 17 (25.8) | 24 (32.9) | |
16.01–24.00 | 126 (32.7) | 15 (23.4) | 11 (32.4) | 49 (33.1) | 29 (43.9) | 22 (30.1) | |
24.00–8.00 | 120 (31.2) | 20 (31.3) | 8 (23.5) | 45 (30.4) | 20 (30.3) | 27 (37.0) | |
Traumatic mechanism, n (%) | 71 (18.4) | 8 (12.5) | 9 (26.5) | 27 (18.2) | 13 (19.7) | 14 (19.2) | 0.55 |
Initial shockable rhythm, n (%) | 58 (15.1) | 6 (9.4) | 5 (14.7) | 22 (14.9) | 13 (19.7) | 12 (16.4) | 0.59 |
Adrenaline given during cardiac arrest, n (%) | 378 (98.2) | 61 (95.3) | 34 (100.0) | 145 (98.0) | 66 (100.0) | 72 (98.6) | 0.30 |
Amiodarone given during cardiac arrest, n (%) | 46 (12.0) | 1 (1.6) | 3 (8.8) | 14 (9.5) | 16 (24.2) | 12 (16.4) | 0.001 |
Lidocaine given during cardiac arrest, n (%) | 27 (7.0) | 0 (0) | 1 (2.9) | 11 (7.4) | 9 (13.6) | 6 (8.2) | 0.04 |
Dextrose given during cardiac arrest, n (%) | 69 (17.9) | 51 (79.7) | 5 (14.7) | 8 (5.4) | 3 (4.6) | 2 (2.7) | <0.001 |
CPR duration, min (SD) | 21.0 (12.9) | 21.9 (10.8) | 24.6 (14.6) | 18.7 (12.9) | 23.2 (13.2) | 21.0 (13.0) | 0.30 |
Intra-arrest blood glucose level, mg/dL (SD) | 171.1 (111.4) | 41.0 (17.9) | 85.6 (8.7) | 138.7 (22.8) | 213.3 (19.2) | 352.7 (93.8) | <0.001 |
Endpoints | All patients (n = 385) | Intra-arrest BG < 70 mg/dL (n = 64) | Intra-Arrest BG 70–99 mg/dL (n = 34) | Intra-Arrest BG 100–180 mg/dL (n = 148) | Intra-Arrest BG 181–250 mg/dL (n = 66) | Intra-Arrest BG > 250 mg/dL (n = 73) | p-Value |
---|---|---|---|---|---|---|---|
Sustained ROSC, n (%) | 188 (48.8) | 20 (31.3) | 12 (35.3) | 91 (61.5) | 28 (42.4) | 37 (50.7) | <0.001 |
Survival to hospital admission, n (%) | 120 (31.3) | 11 (17.2) | 8 (23.5) | 59 (40.1) | 20 (30.3) | 22 (30.1) | 0.02 |
Survival to hospital discharge, n (%) | 43 (11.4) | 3 (4.8) | 4 (11.8) | 19 (13.3) | 8 (12.3) | 9 (12.5) | 0.49 |
Favorable neurological outcome at discharge, n (%) | 13 (3.5) | 1 (1.6) | 1 (3.0) | 5 (3.6) | 1 (1.6) | 5 (7.1) | 0.39 |
Outcomes | Odds Ratios | 95% Confidence Intervals | p-Value |
---|---|---|---|
Sustained return of spontaneous circulation | |||
<70 mg/dL | 0.36 | 0.14–0.99 | 0.05 |
70–99 mg/dL | 0.33 | 0.12–0.93 | 0.04 |
100–180 mg/dL | 1 | Reference | - |
181–250 mg/dL | 0.64 | 0.31–1.32 | 0.23 |
>250 mg/dL | 0.55 | 0.37–1.10 | 0.09 |
Survival to hospital admission | |||
<70 mg/dL | 0.32 | 0.10–1.03 | 0.06 |
70–99 mg/dL | 0.49 | 0.17–1.48 | 0.21 |
100–180 mg/dL | 1 | Reference | - |
181–250 mg/dL | 1.04 | 0.49–2.19 | 0.92 |
>250 mg/dL | 0.58 | 0.28–1.18 | 0.13 |
Survival to hospital discharge | |||
<70 mg/dL | 0.67 | 0.12–3.84 | 0.66 |
70–99 mg/dL | 0.91 | 0.23–3.69 | 0.90 |
100–180 mg/dL | 1 | Reference | - |
181–250 mg/dL | 1.67 | 0.61–4.57 | 0.32 |
>250 mg/dL | 0.89 | 0.34–2.33 | 0.82 |
Favorable neurological outcome at discharge | |||
<70 mg/dL | 1.36 | 0.08–23.47 | 0.83 |
70–99 mg/dL | 1.16 | 0.09–15.53 | 0.91 |
100–180 mg/dL | 1 | Reference | - |
181–250 mg/dL | 1.03 | 0.08–12.70 | 0.98 |
>250 mg/dL | 1.81 | 0.33–10.01 | 0.50 |
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Wongtanasarasin, W.; Ungrungseesopon, N.; Phinyo, P. Association between Intra-Arrest Blood Glucose Level and Outcomes of Resuscitation at the Emergency Department: A Retrospective Study. J. Clin. Med. 2022, 11, 3067. https://doi.org/10.3390/jcm11113067
Wongtanasarasin W, Ungrungseesopon N, Phinyo P. Association between Intra-Arrest Blood Glucose Level and Outcomes of Resuscitation at the Emergency Department: A Retrospective Study. Journal of Clinical Medicine. 2022; 11(11):3067. https://doi.org/10.3390/jcm11113067
Chicago/Turabian StyleWongtanasarasin, Wachira, Nat Ungrungseesopon, and Phichayut Phinyo. 2022. "Association between Intra-Arrest Blood Glucose Level and Outcomes of Resuscitation at the Emergency Department: A Retrospective Study" Journal of Clinical Medicine 11, no. 11: 3067. https://doi.org/10.3390/jcm11113067