Pharmacokinetic Pharmacodynamic Modelling Contributions to Improve Paediatric Anaesthesia Practice
Abstract
:1. Introduction
2. Models
3. Key Elements of Paediatric PKPD Models
3.1. Size
3.2. Age
3.3. Body Composition
3.4. Obesity
3.5. Normal Fat Mass
4. Target Concentration Concepts
4.1. Achieving the Target Effect
4.2. Defining Target Concentration
5. Practical Applications
5.1. Using Variability for Dose Estimation
5.2. Improving Inhalational Agent Use
5.2.1. Integrated PKPD for Inhaled Drugs
5.2.2. Sevoflurane Induction, Propofol Maintenance
5.3. Improving Propofol Intravenous Anaesthesia
5.3.1. Propofol Target-Controlled Infusion
5.3.2. Manual Infusion
5.3.3. Predicting Offset of Propofol’s Effects
5.4. The Loading Dose of Dexmedetomidine
5.5. Drug Interactions
5.5.1. Understanding Remifentanil Contribution to Bispectral Index
5.5.2. Midazolam and Protease Inhibitors
5.6. Acute Pain Management
5.6.1. Morphine
5.6.2. Oxycodone
5.7. Models for Education
6. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Morse, J.D.; Cortinez, L.I.; Anderson, B.J. Pharmacokinetic Pharmacodynamic Modelling Contributions to Improve Paediatric Anaesthesia Practice. J. Clin. Med. 2022, 11, 3009. https://doi.org/10.3390/jcm11113009
Morse JD, Cortinez LI, Anderson BJ. Pharmacokinetic Pharmacodynamic Modelling Contributions to Improve Paediatric Anaesthesia Practice. Journal of Clinical Medicine. 2022; 11(11):3009. https://doi.org/10.3390/jcm11113009
Chicago/Turabian StyleMorse, James D., Luis Ignacio Cortinez, and Brian J. Anderson. 2022. "Pharmacokinetic Pharmacodynamic Modelling Contributions to Improve Paediatric Anaesthesia Practice" Journal of Clinical Medicine 11, no. 11: 3009. https://doi.org/10.3390/jcm11113009