Effect of Dexmedetomidine on Early Postoperative Cognitive Function in Patients Undergoing Arthroscopic Shoulder Surgery in Beach Chair Position: A Randomized Double-Blind Study
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Population
2.2. Anesthetic Management and Procedures
2.3. Study Design and Serum Biomarker Measurement
2.4. Neurologic Evaluation
2.5. Statistical Analysis
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Characteristics | Group D (n = 40) | Group C (n = 38) | p-Value |
---|---|---|---|
Age (years) | 65.0 ± 5.9 | 66.3 ± 6.3 | 0.344 |
Male/female | 23/17 | 19/21 | 0.370 |
Height (cm) | 162.1 ± 8.1 | 159.0 ± 8.1 | 0.089 |
Weight (kg) | 63.7 ± 9.8 | 66.5 ± 11.5 | 0.249 |
Body mass index (kg/m2) | 25.2 ± 3.1 | 25.1 ± 3.0 | 0.947 |
ASA classification 1/2/3, n (%) | 0.471 | ||
1 | 5 (12.5%) | 4 (10.5%) | |
2 | 25 (62.5%) | 21 (55.3%) | |
3 | 10 (25%) | 13 (34.2%) | |
Hypertension, n (%) | 17 (42.5%) | 21 (55.3%) | 0.373 |
Diabetes, n (%) | 5 (12.5%) | 7 (18.4%) | 1.000 |
Intraoperative data | |||
Anesthesia time (min) | 139.1 ± 31.6 | 133.0 ± 36.7 | 0.718 |
Operation time (min) | 92.6 ± 31.3 | 90.0 ± 34.7 | 0.423 |
BCP duration (min) | 104.5 ± 31.8 | 96.9 ± 29.0 | 0.281 |
Hypotensive duration (min) | 73.3 ± 24.3 | 74.4 ± 27.9 | 0.857 |
Total remifentanil infusion (μg) | 618 (363, 800) | 622 (400, 700) | 0.669 |
Total dexmedetomidine infusion (μg) | 93.4 ± 26.0 | - | <0.001 |
Total ephedrine dose (mg) | 12 (8, 20) | 12 (6, 18) | 0.353 |
Total phenylephrine dose (μg) | 0 (0, 37.5) | 0 (0, 0) | 0.685 |
Variable | Group D (n = 40) | Group C (n = 38) | p Value |
---|---|---|---|
POCD, n (%) | 9 (22.5%) | 9 (23.7%) | 0.901 |
MMSE-K score | 0.070 | ||
Pre-induction | 28.0 (27.0–29.0) | 28.0 (26.0–29.0) | |
Post-operation | 29.0 (28.0–29.0) | 28.0 (26.0–29.0) | |
Visuomotor construction battery test score | 0.004 | ||
Pre-induction | 55.0 (53.0–57.0) | 55.5 (52.3–57.0) | |
Post-operation | 56.0 (53.3–58.0) *† | 54.0 (50.0–56.0) |
Variables | Group D (n = 40) | Group C (n = 38) | p Value |
---|---|---|---|
S100β (pg/mL) | 0.236 | ||
Pre-induction | 32.9 ± 12.2 | 36.8 ± 12.9 | |
Post-operation | 62.5 (50.8–90.8) * | 69.3 ± 22.4 * |
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Kim, N.; Kim, K.H.; Choi, Y.S.; Song, S.H.; Choi, S.H. Effect of Dexmedetomidine on Early Postoperative Cognitive Function in Patients Undergoing Arthroscopic Shoulder Surgery in Beach Chair Position: A Randomized Double-Blind Study. J. Clin. Med. 2022, 11, 2970. https://doi.org/10.3390/jcm11112970
Kim N, Kim KH, Choi YS, Song SH, Choi SH. Effect of Dexmedetomidine on Early Postoperative Cognitive Function in Patients Undergoing Arthroscopic Shoulder Surgery in Beach Chair Position: A Randomized Double-Blind Study. Journal of Clinical Medicine. 2022; 11(11):2970. https://doi.org/10.3390/jcm11112970
Chicago/Turabian StyleKim, Namo, Kwan Hyung Kim, Yong Seon Choi, Sei Han Song, and Seung Ho Choi. 2022. "Effect of Dexmedetomidine on Early Postoperative Cognitive Function in Patients Undergoing Arthroscopic Shoulder Surgery in Beach Chair Position: A Randomized Double-Blind Study" Journal of Clinical Medicine 11, no. 11: 2970. https://doi.org/10.3390/jcm11112970