COVID-19 Vaccination Coverage and Factors Influencing Vaccine Hesitancy among Patients with Inborn Errors of Immunity in Latvia: A Mixed-Methods Study
Abstract
:1. Introduction
2. Materials and Methods
2.1. Design
2.2. Quantitative Study
2.2.1. Study Population
2.2.2. Statistical Analysis
2.3. Qualitative Study
2.3.1. Study Population and Sample
2.3.2. Data Collection
2.3.3. Data Analysis
2.3.4. Ethics Statement
3. Results
3.1. Quantitative Findings
3.1.1. Population Characterization
3.1.2. Vaccination Coverage
3.2. Qualitative Study
3.2.1. Study Sample Characterization
3.2.2. Findings of Thematic Analysis
3.3. Theme 1. Fear and Uncertainty
3.3.1. Fear
3.3.2. Too Many Unknowns
3.4. Theme 2. Risk and Benefit Assessment: COVID-19 Vaccine—Is It Worth It?
3.4.1. Concerns about Negative Outcomes
3.4.2. Doubts about the Positive Effect
3.4.3. Overall Lack of Confidence in the Vaccine
3.5. Theme 3. External Influences: The Dark Horse of the Decision-Making—People around Us
3.5.1. Stories of Health Problems after Vaccination
3.5.2. Public Figures and Doctors against Vaccination
3.6. Theme 4. Individuals against the System
3.6.1. The Right to Choose
3.6.2. Mistrust
3.6.3. General Disbelief of Official Information
3.7. Theme 5. Beliefs about Vaccines and COVID-19
3.7.1. Beliefs about Vaccination in General
3.7.2. Beliefs about COVID-19 or the Vaccine against It
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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IEI Category | Total Number of Alive IEI Patients | Age Group Pediatric/ Adult | Receives Immunoglobulin Replacement Yes/No | Vaccination Status Yes/No/ Non-Eligible for Vaccination */ No Information |
---|---|---|---|---|
Immunodeficiencies affecting cellular and humoral immunity | 4 | 4/0 | 2/2 | 0/2/2/0 |
Combined immunodeficiencies with associated or syndromic features | 60 | 53/7 | 2/58 | 11/33/16/0 |
Predominantly antibody deficiency | 219 | 65/154 | 21/198 | 131/70/0/18 |
Of those, SIgAD | 195 | 61/134 | 0/195 | 115/62/0/18 |
Diseases of immune dysregulation | 4 | 3/1 | 2/2 | 1/3/0/0 |
Congenital defects of phagocyte number or function | 18 | 10/8 | 0/18 | 5/10/1/2 |
Defects in intrinsic and innate immunity | 4 | 3/1 | 2/2 | 2/0/2/0 |
Autoinflammatory disorders | 12 | 9/3 | 0/12 | 4/6/0/2 |
Complement deficiencies | 11 | 1/10 | 0/11 | 6/5/0/0 |
Bone marrow failure | 6 | 1/5 | 0/6 | 5/0/1/0 |
Phenocopies of inborn errors of immunity | 1 | 0/1 | 1/0 | 1/0/0/0 |
Unclassified immunodeficiency | 2 | 2/0 | 0/2 | 0/1/0/1 |
Total | 341 | 151/190 | 30/311 | 166/149/3/23 |
Age Group, Years | Latvian General Population, % Vaccinated [52] | Selective IgA Deficiency Patients, % Vaccinated | Other IEI Patients, % Vaccinated |
---|---|---|---|
12–19 | 68 | 51.0 | 26.5 |
20–29 | 81 | 82.8 | 72.2 |
30–39 | 77 | 80.0 | 90.9 |
40–49 | 79 | 70.0 | 60.0 |
50–59 | 81 | 80.0 | 83.3 |
60+ | 71 | 60.0 | 75.0 |
Total | 68% | 70.9% | 58.8% |
Code | Interviewee | Diagnosis Group | Receives Immunoglobulin Replacement | Gender of the Patient | Age Group of the Patient, Years |
---|---|---|---|---|---|
IEI1 | Parent | Combined immunodeficiencies with associated or syndromic Features | No | F | 5–11 |
IEI2 | Parent | Predominantly antibody Deficiency | Yes | M | 5–11 |
IEI3 | Parent | Predominantly antibody Deficiency | No | M | 5–11 |
IEI4 | Parent | Diseases of immune Dysregulation | Yes | M | 12–18 |
IEI5 | Parent | Predominantly antibody Deficiency | Yes | M | 5–11 |
IEI6 | Parent | Predominantly antibody Deficiency | No | F | 12–18 |
IEI7 | Patient | Predominantly antibody Deficiency | Yes | F | 40–60 |
IEI8 | Parent | Combined immunodeficiencies | No | F | 12–18 |
IEI9 | Patient | Predominantly antibody Deficiency | No | F | >60 |
IEI10 | Patient | Complement deficiency | No | F | 19–40 |
IEI11 | Parent | Combined immunodeficiencies with associated or syndromic Features | No | F | 5–11 |
IEI12 | Patient | Predominantly antibody Deficiency | No | F | 19–40 |
IEI13 | Parent | Autoinflammatory disease | No | F | 12–18 |
IEI14 | Patient | Predominantly antibody Deficiency | No | M | 40–60 |
IEI15 | Patient | Complement deficiency | No | F | 40–60 |
IEI16 | Parent | Combined immunodeficiencies with associated or syndromic Features | No | M | 12–18 |
Themes | Subthemes |
---|---|
1. Fear and uncertainty | Fear Too many unknowns |
2. Risk and benefit assessment: COVID-19 vaccine—is it worth it? | Concerns about negative outcomes Doubts about the positive effect Overall lack of confidence in the vaccine |
3. External influences: The dark horse of the decision-making—people around us | Stories of health problems after vaccination Public figures and doctors against vaccination |
4. Individuals against the system | The right to choose Mistrust General disbelief of official information |
5. Beliefs about vaccines and COVID-19 | Beliefs about vaccines in general Beliefs about COVID-19 and its vaccine |
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© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
Share and Cite
Lucane, Z.; Kursite, M.; Sablinskis, K.; Gailite, L.; Kurjane, N. COVID-19 Vaccination Coverage and Factors Influencing Vaccine Hesitancy among Patients with Inborn Errors of Immunity in Latvia: A Mixed-Methods Study. Vaccines 2023, 11, 1637. https://doi.org/10.3390/vaccines11111637
Lucane Z, Kursite M, Sablinskis K, Gailite L, Kurjane N. COVID-19 Vaccination Coverage and Factors Influencing Vaccine Hesitancy among Patients with Inborn Errors of Immunity in Latvia: A Mixed-Methods Study. Vaccines. 2023; 11(11):1637. https://doi.org/10.3390/vaccines11111637
Chicago/Turabian StyleLucane, Zane, Mirdza Kursite, Kristaps Sablinskis, Linda Gailite, and Natalja Kurjane. 2023. "COVID-19 Vaccination Coverage and Factors Influencing Vaccine Hesitancy among Patients with Inborn Errors of Immunity in Latvia: A Mixed-Methods Study" Vaccines 11, no. 11: 1637. https://doi.org/10.3390/vaccines11111637