Application of Grey Relational Analysis to Predict Dementia Tendency by Cognitive Function, Sleep Disturbances, and Health Conditions of Diabetic Patients
Abstract
:1. Introduction
2. Methods
2.1. Study Design
2.2. Participants
2.3. Setting and Sampling
2.4. Variables and Research Instruments
2.5. Pittsburgh Sleep Quality Index (PSQI)
2.6. Activity of Daily Living
2.7. Mini Mental State Examination (MMSE)
2.8. Geriatric Depression Scale
2.9. Health-Related QOL
2.10. Ethical Considerations
2.11. Data Analysis
2.12. Grey Relational Analysis (GRA)
3. Results
3.1. Participant Characteristics
3.2. Relationships between Variables
3.3. Grey Relational Analysis
4. Discussion
4.1. Study Variables
4.2. Glycemic Control and Dementia
4.3. Sleep Quality and Glycemic Control
4.4. Sleep Quality, GDS, and QOL
5. Limitations
6. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Variables | Mean | SD | Range |
---|---|---|---|
Age | 66.6 | 7.6 | 51–89 |
Duration of diabetes (months) | 136.3 | 99.1 | 4–420 |
Glycated hemoglobin (HbA1C, %) | 7.4 | 1.2 | 5.4–12.7 |
Fasting sugar (mg/dL) | 140.7 | 58.8 | 58–557 |
Body mass index (BMI, kg/m2) | 25.9 | 3.8 | 18.4–40.0 |
Triglyceride (TG, mg/dL) | 157.9 | 123.0 | 39–991 |
Total cholesterol (mg/dL) | 162.3 | 46.7 | 34–480 |
High density lipoprotein-cholesterol (HDL-C, mg/dL) | 49.7 | 12.9 | 27–108 |
Low density lipoprotein-cholesterol (LDL-C, mg/dL) | 84.0 | 26.1 | 11–180 |
Mini-Mental State Examination (MMSE) | 27.2 | 3.3 | 12–30 |
Activity of daily living (ADL) | 99.6 | 2.7 | 70–100 |
Geriatric depressive symptoms (GDS) | 2.6 | 2.4 | 0–13 |
Physical quality of life (PQOL) | 74.5 | 18.8 | 13–99 |
Mental quality of life (MQOL) | 79.5 | 12.4 | 28–95 |
Sleep quality (SQ) | 6.7 | 3.3 | 1–17 |
n | % | ||
Gender | |||
Male | 116 | 52.7 | |
Female | 104 | 47.3 | |
Marital status | |||
Single | 9 | 4.1 | |
Separated/divorced | 16 | 7.3 | |
Widowed | 40 | 18.2 | |
Married | 155 | 70.5 | |
Education (school years) | |||
0 | 10 | 4.5 | |
≦6 | 83 | 37.7 | |
≦6–9 | 42 | 19.1 | |
≦9–12 | 76 | 34.5 | |
>12 | 9 | 4.2 | |
Household income (TWD) | |||
<25,000 | 104 | 47.3 | |
25,001–50,000 | 72 | 32.7 | |
50,001–75,000 | 24 | 10.9 | |
75,001–100,000 | 9 | 4.1 | |
>100,000 | 11 | 5.0 | |
Complications | |||
0 | 23 | 10.5 | |
≧1 | 197 | 89.5 | |
MMSE | |||
Severe | 4 | 1.8 | |
Mild | 26 | 11.8 | |
Normal | 190 | 86.4 | |
GDS | |||
None | 190 | 86.4 | |
Mild | 27 | 12.2 | |
Severe | 3 | 1.4 |
Variables | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1. Age | 1 | |||||||||||||||||
2. Education | −0.42 ** | 1 | ||||||||||||||||
3. Duration | 0.17 * | −0.05 | 1 | |||||||||||||||
4. Income | −0.17 * | 0.28 ** | 0.01 | 1 | ||||||||||||||
5. BMI | −0.1 | 0.00 | −0.09 | 0.00 | 1 | |||||||||||||
6. Fasting sugar | −0.15 * | −0.05 | −0.01 | 0.03 | 0.06 | 1 | ||||||||||||
7. HbA1C | −0.12 | −0.09 | 0.26 ** | 0.02 | 0.13 | 0.57 ** | 1 | |||||||||||
8. Complications | 0.05 | −0.13 | 0.06 | −0.08 | 0.14 * | 0.08 | 0.02 | 1 | ||||||||||
9. TG | −0.10 | 0.07 | −0.02 | −0.01 | 0.01 | 0.26 ** | 0.17 * | 0.01 | 1 | |||||||||
10. TChol | −0.01 | 0.03 | 0.01 | 0.02 | 0.01 | 0.07 | 0.06 | 0.11 | 0.49 ** | 1 | ||||||||
11. HDL-C | −0.03 | 0.07 | 0.00 | 0.16 * | −0.10 | −0.18 ** | −0.14 * | −0.11 | −0.33 ** | 0.12 | 1 | |||||||
12. LDL-C | 0.10 | 0.00 | −0.06 | 0.04 | −0.03 | −0.05 | −0.11 | −0.09 | 0.10 | 0.50 ** | 0.12 | 1 | ||||||
13. MMSE | −0.33 ** | 0.45 ** | 0.04 | 0.27 ** | 0.14 * | 0.16 * | 0.09 | 0.02 | 0.02 | 0.08 | 0.05 | 0.07 | 1 | |||||
14. ADL | −0.12 | 0.03 | −0.10 | −0.08 | 0.06 | 0.06 | 0.09 | −0.05 | −0.04 | −0.01 | 0.13 | −0.10 | 0.07 | 1 | ||||
15. GDSs | 0.07 | −0.09 | 0.06 | −0.06 | −0.04 | 0.04 | −0.04 | −0.00 | 0.19 ** | 0.10 | −0.01 | 0.02 | −0.14 * | −0.08 | 1 | |||
16. SQ | −0.00 | −0.06 | 0.03 | −0.00 | 0.01 | 0.02 | −0.02 | 0.03 | −0.00 | −0.06 | 0.07 | −0.06 | 0.07 | 0.02 | 0.40 ** | 1 | ||
17. MQOL | −0.05 | 0.15 * | −0.04 | −0.08 | −0.02 | 0.04 | 0.02 | 0.04 | −0.11 | −0.06 | 0.05 | −0.08 | 0.07 | 0.27 ** | −0.68 ** | −0.38 ** | 1 | |
18. PQOL | −0.12 | 0.20 ** | −0.08 | −0.00 | −0.06 | −0.06 | 0.05 | 0.07 | −0.13 | −0.05 | 0.12 | −0.01 | 0.04 | 0.18 ** | −0.49 ** | −0.33 ** | 0.58 ** | 1 |
No | BMI | HbA1C | Fasting Sugar | TCholesterol | HDL-C | LDL-C | TG | SQ | MMSE | GDSs | PQOL | MQOL |
---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | 0.8487 | 0.7561 | 0.4077 | 0.6774 | 0.8677 | 0.8581 | 0.3958 | 0.7500 | 0.3333 | 0.5714 | 0.7168 | 0.8410 |
2 | 0.8006 | 0.7887 | 0.4100 | 0.6752 | 1 | 0.8268 | 0.3967 | 0.8571 | 0.3333 | 0.5714 | 0.7297 | 0.8204 |
3 | 0.7709 | 0.7439 | 0.3967 | 0.6562 | 0.8235 | 0.7690 | 0.3811 | 0.8571 | 0.3333 | 0.5454 | 0.8571 | 0.8204 |
4 | 0.8059 | 0.7349 | 0.3904 | 0.7000 | 0.8467 | 0.8601 | 0.3964 | 0.8780 | 0.375 | 0.5714 | 0.7980 | 0.8375 |
5 | 0.8224 | 0.7593 | 0.4077 | 0.6961 | 0.8076 | 0.8383 | 0.4060 | 0.7500 | 0.3461 | 0.5454 | 0.9152 | 0.8589 |
6 | 0.8416 | 0.7530 | 0.4083 | 0.6695 | 0.8076 | 0.8212 | 0.3718 | 0.7500 | 0.3333 | 0.5217 | 0.6694 | 0.7671 |
7 | 0.8487 | 0.7469 | 0.3978 | 0.6428 | 0.8076 | 0.7469 | 0.3729 | 0.7346 | 0.5294 | 0.5000 | 0.7465 | 0.7790 |
8 | 0.8259 | 0.7500 | 0.4049 | 0.6535 | 0.7894 | 0.7690 | 0.3852 | 0.7826 | 0.3600 | 0.6666 | 0.9364 | 0.8305 |
9 | 0.8183 | 0.8169 | 0.4027 | 0.6759 | 0.7216 | 0.7823 | 0.5052 | 0.7659 | 0.6923 | 0.4800 | 0.7826 | 0.7730 |
10 | 0.7951 | 0.7787 | 0.3962 | 0.6774 | 0.7636 | 0.8325 | 0.3825 | 0.9473 | 0.4285 | 0.7500 | 0.8181 | 0.8973 |
11 | 0.8430 | 0.7689 | 0.3983 | 0.7175 | 0.8713 | 0.8194 | 0.3903 | 0.7659 | 0.3333 | 0.5217 | 0.7714 | 0.7790 |
12 | 0.8066 | 0.9384 | 0.7500 | 0.6468 | 0.7342 | 0.7658 | 0.4107 | 0.7826 | 0.3913 | 0.5714 | 0.7431 | 0.8204 |
13 | 0.8634 | 0.7721 | 0.4089 | 0.5855 | 0.7894 | 0.7658 | 0.3742 | 0.8780 | 0.4285 | 0.5454 | 0.8481 | 0.7913 |
14 | 0.8688 | 0.8280 | 0.4796 | 0.6596 | 0.7608 | 0.7891 | 0.4114 | 0.7200 | 0.375 | 0.4800 | 0.7980 | 0.7821 |
15 | 0.7744 | 0.7530 | 0.4100 | 0.6617 | 0.7806 | 0.8030 | 0.3838 | 0.7200 | 0.4285 | 0.5000 | 0.6612 | 0.7760 |
16 | 0.8169 | 0.8840 | 0.5240 | 0.6870 | 0.8641 | 0.8501 | 0.3652 | 0.7826 | 0.3333 | 0.5217 | 0.6835 | 0.7882 |
… | … | … | … | … | … | … | … | … | … | … | … | … |
219 | 0.8270 | 0.7721 | 0.3962 | 0.7526 | 0.7553 | 0.7484 | 0.3789 | 0.7346 | 0.3461 | 0.5 | 0.6923 | 0.7701 |
220 | 0.8332 | 0.7593 | 0.3823 | 0.6468 | 0.7266 | 0.726 | 0.4344 | 0.9 | 0.3333 | 0.6666 | 0.8140 | 0.7730 |
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Huang, C.-Y.; Lin, Y.-C.; Lu, Y.-C.; Chen, C.-I. Application of Grey Relational Analysis to Predict Dementia Tendency by Cognitive Function, Sleep Disturbances, and Health Conditions of Diabetic Patients. Brain Sci. 2022, 12, 1642. https://doi.org/10.3390/brainsci12121642
Huang C-Y, Lin Y-C, Lu Y-C, Chen C-I. Application of Grey Relational Analysis to Predict Dementia Tendency by Cognitive Function, Sleep Disturbances, and Health Conditions of Diabetic Patients. Brain Sciences. 2022; 12(12):1642. https://doi.org/10.3390/brainsci12121642
Chicago/Turabian StyleHuang, Chiung-Yu, Yu-Ching Lin, Yung-Chuan Lu, and Chun-I Chen. 2022. "Application of Grey Relational Analysis to Predict Dementia Tendency by Cognitive Function, Sleep Disturbances, and Health Conditions of Diabetic Patients" Brain Sciences 12, no. 12: 1642. https://doi.org/10.3390/brainsci12121642