Impact of Pro-Argin on the Oral Health-Related Quality of Life: A 24-Week Randomized, Parallel-Group, Multicenter Study

Round 1

Reviewer 1 Report

Dear Authors,

The article: 'Impact of Pro-Argin on the oral health-related quality of life: A 24-week randomised, parallel group, multicentre study' was to focused on the efficacy of Pro-Argin with respect to the OHRQoL using in-office and at-home treatment approaches in the same population for more than 24 weeks.

English language and style are fine.

Punctuation mistakes should be corrected. 

Correct the address of the corresponding author.

The purpose of the work should be clearly defined.

Materials and methods

Number the subsections of materials and methods.

In the first section, describe the group under study, in the next section, the inclusion criteria.
Enter how the group was calculated in the statistics section.

Results

The p-value should be in italics.

The table should be prepared using MDPI guidelines.

The quality of figure 1 shoud be better. Figure captions should be together with the figure.

Discussion is clearly presented.

It is not allowed to write numbers in the conclusions.

line 335: Samuel et al. compared the effect of Pro-Argin with two positive controls, Gluma® (2-hydroxyethyl methacrylate and glutaraldehyde) and NovaMin® (5% calcium sodium phosphosilicate) after a single application and after 30 days. All three desensitisers led to a reduction in CDH and Pro-Argin exhibited a significant reduction in the CDH values (p< 0.016) [37]. should be:
Samuel et al. [37] compared the effect of Pro-Argin with two positive controls, Gluma® (2-hydroxyethyl methacrylate and glutaraldehyde) and NovaMin® (5% calcium sodium phosphosilicate) after a single application and after 30 days. All three desensitisers led to a reduction in CDH and Pro-Argin exhibited a significant reduction in the CDH values (p < 0.016).

References should be prepared in accordance with the MDPI guidelines. References must be numbered in order of appearance in the text (including citations in tables and legends) and listed individually at the end of the manuscript. We recommend preparing the references with a bibliography software package, such as EndNote, ReferenceManager or Zotero to avoid typing mistakes and duplicated references. Include the digital object identifier (DOI) for all references where available. Citations and references in the Supplementary Materials are permitted provided that they also appear in the reference list here. In the text, reference numbers should be placed in square brackets [ ] and placed before the punctuation; for example [1], [1–3] 
or [1,3]. For embedded citations in the text with pagination, use both parentheses and brackets to indicate the reference number and page numbers; for example [5] (p. 10), or [6] (pp. 101–105).

To sum up, article can be accepted after major revison.

Author Response

Dear Editor, all the helpful comments could be adressed. Please see  the attached file including the point-by-point comments.

Beste regards

Author Response File: Author Response.docx

Reviewer 2 Report

Dear Authors,

The experimental article is interesting and it investigates an aspect that frequently affects the quality of life of patients.

In attach I raised some remarks.

I hope you could find them useful to improve your research.

Best regards

Riccardo Beltrami

Comments for author File: Comments.pdf

Author Response

Dear Editor, we have included and corrected all points raised by reviewer 2. Please see the comments in the attached pdf. Thank you very much for the helpful comments.

Best regards

Author Response File: Author Response.pdf

Round 2

Reviewer 1 Report

Article must be prepared using MDPI guidelines (use of a template, text layout, reference style).

To sum up, article can be accepted after major revison.

Author Response

Dear Editor,

all suggestions (using MDPI guidelines, template, text layout, reference style) were adressed and corrected.

Finally, the conclusion was improved, spell check was done.

Thank you very much for the helpful comments.

Best regards

Mary Michaelis, Christian Gernhardt