Epidemiology of Pneumococcal Pneumonia in Louisville, Kentucky, and Its Estimated Burden of Disease in the United States
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Design and Study Population
2.2. Inclusion and Exclusion Criteria
2.3. Human Subject Protection
2.4. Specimen Collection and Definition of Pneumococcal Pneumonia
2.5. Incidence Calculation in Louisville
2.6. Geospatial Epidemiology
2.7. Clinical Outcomes
2.8. Extrapolations to the United States
2.9. Serotype Incidence
2.10. Serotype Associations with Comorbidities and Clinical Outcomes
2.11. Serotype Virulence
3. Results
3.1. Incidence of Pneumococcal Pneumonia
3.1.1. Proportion of Pneumococcal Pneumonia
3.1.2. Incidence of Hospitalizations Due to Pneumococcal Pneumonia
3.1.3. Incidence of Pneumococcal Pneumonia by Age and Comorbidity
3.1.4. Association of Pneumococcal Pneumonia with Income Level, Race, and Age
3.2. Clinical Outcomes
3.2.1. Severe CAP, Clinical Failure, and Cardiovascular Events
3.2.2. Mortality
3.3. Estimation of Burden of Disease in the United States
3.4. Serotypes
3.4.1. Serotype Incidence
3.4.2. Serotype Associations with Comorbidities and Clinical Outcomes
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Variable | Value |
---|---|
Total N | 708 |
Demographics | |
Age, median (IQR) | 65 (56–75) |
Male sex, n (%) | 323 (46) |
Black or African American race, n (%) | 123 (17) |
Medical and social history, n (%) | |
Obese | 238 (34) |
HIV disease | 21 (3) |
Neoplastic disease (active or within the last year) | 86 (12) |
Renal disease | 184 (26) |
Chronic renal failure | 44 (6) |
Congestive heart failure (CHF) | 199 (28) |
Chronic obstructive pulmonary disease (COPD) | 403 (57) |
Stroke | 85 (12) |
Current smoker | 317 (45) |
Diabetes mellitus | 214 (30) |
Severity of disease | |
ICU admission, n (%) | 144 (20) |
Altered mental status on admission, n (%) | 96 (14) |
Vasopressors on admission, n (%) | 25 (4) |
Ventilatory support on admission, n (%) | 100 (14) |
Pneumonia Severity Index, median (IQR) | 97 (74–127) |
PSI risk class IV or V, n (%) | 407 (57) |
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© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
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Ramirez, J.; Furmanek, S.; Chandler, T.R.; Wiemken, T.; Peyrani, P.; Arnold, F.; Mattingly, W.; Wilde, A.; Bordon, J.; Fernandez-Botran, R.; et al. Epidemiology of Pneumococcal Pneumonia in Louisville, Kentucky, and Its Estimated Burden of Disease in the United States. Microorganisms 2023, 11, 2813. https://doi.org/10.3390/microorganisms11112813
Ramirez J, Furmanek S, Chandler TR, Wiemken T, Peyrani P, Arnold F, Mattingly W, Wilde A, Bordon J, Fernandez-Botran R, et al. Epidemiology of Pneumococcal Pneumonia in Louisville, Kentucky, and Its Estimated Burden of Disease in the United States. Microorganisms. 2023; 11(11):2813. https://doi.org/10.3390/microorganisms11112813
Chicago/Turabian StyleRamirez, Julio, Stephen Furmanek, Thomas R. Chandler, Timothy Wiemken, Paula Peyrani, Forest Arnold, William Mattingly, Ashley Wilde, Jose Bordon, Rafael Fernandez-Botran, and et al. 2023. "Epidemiology of Pneumococcal Pneumonia in Louisville, Kentucky, and Its Estimated Burden of Disease in the United States" Microorganisms 11, no. 11: 2813. https://doi.org/10.3390/microorganisms11112813