Multiphoton Microscopy for Identifying Collagen Signatures Associated with Biochemical Recurrence in Prostate Cancer Patients
Abstract
:1. Introduction
2. Materials and Methods
3. Results
3.1. Characterization of Normal and Reactive Stroma in Prostate Tissue Using MPM
3.2. Quantifiable MPM-Identified Prostate Stromal Signatures
3.3. MPM-Identified Prostate Stromal Features Associated with Biochemical Recurrence
4. Discussion
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Variable | Univariable Analysis | |||
---|---|---|---|---|
HR | 95% CI | p Value >|z| | ||
Collagen Area Fraction (AF) | 1.05 | 1.01 | 1.09 | 0.014 |
Collagen Fiber Intensity (IR) | 1.02 | 1.01 | 1.04 | 0.006 |
Normalized Intensity (IR/IR + IG) | 1.14 | 1.05 | 1.24 | 0.003 |
Collagen Fiber Length (mm) | 1.07 | 0.95 | 1.21 | 0.245 |
Collagen Fiber Width (mm) | 3.08 | 1.07 | 8.88 | 0.038 |
Collagen Fiber Angle (degrees) | 1.25 | 1.01 | 1.55 | 0.041 |
Collagen Fiber Coherence | 0.95 | 0.90 | 1.01 | 0.105 |
Variable | Univariable Analysis | |||
---|---|---|---|---|
HR | 95% CI | p Value >|z| | ||
Collagen Area Fraction (AF) | 1.05 | 0.99 | 1.11 | 0.082 |
Collagen Fiber Intensity (IR) | 1.07 | 1.02 | 1.12 | 0.003 |
Normalized Intensity (IR/IR + IG) | 1.05 | 0.99 | 1.11 | 0.006 |
Collagen Fiber Length (mm) | 0.93 | 0.68 | 1.28 | 0.669 |
Collagen Fiber Width (mm) | 1.07 | 0.10 | 11.40 | 0.957 |
Collagen Fiber Angle (degrees) | 1.08 | 0.88 | 1.33 | 0.463 |
Collagen Fiber Coherence | 1.07 | 1.02 | 1.12 | 0.205 |
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Pavlova, I.P.; Nair, S.S.; Lundon, D.; Sobotka, S.; Roshandel, R.; Treacy, P.-J.; Ratnani, P.; Brody, R.; Epstein, J.I.; Ayala, G.E.; et al. Multiphoton Microscopy for Identifying Collagen Signatures Associated with Biochemical Recurrence in Prostate Cancer Patients. J. Pers. Med. 2021, 11, 1061. https://doi.org/10.3390/jpm11111061
Pavlova IP, Nair SS, Lundon D, Sobotka S, Roshandel R, Treacy P-J, Ratnani P, Brody R, Epstein JI, Ayala GE, et al. Multiphoton Microscopy for Identifying Collagen Signatures Associated with Biochemical Recurrence in Prostate Cancer Patients. Journal of Personalized Medicine. 2021; 11(11):1061. https://doi.org/10.3390/jpm11111061
Chicago/Turabian StylePavlova, Ina P., Sujit S. Nair, Dara Lundon, Stanislaw Sobotka, Reza Roshandel, Patrick-Julien Treacy, Parita Ratnani, Rachel Brody, Jonathan I. Epstein, Gustavo E. Ayala, and et al. 2021. "Multiphoton Microscopy for Identifying Collagen Signatures Associated with Biochemical Recurrence in Prostate Cancer Patients" Journal of Personalized Medicine 11, no. 11: 1061. https://doi.org/10.3390/jpm11111061