P16-CD8-Ki67 Triple Algorithm for Prediction of CDKN2A Mutations in Patients with Multiple Primary and Familial Melanoma
Round 1
Reviewer 1 Report
Comments and Suggestions for AuthorsThis interesting article proposes an innovative algorithm that could have useful implications in clinical practice in the future. Although the sample size is small, future studies on the topic will be able to test the proposed algorithm.
Comments on the Quality of English LanguageEnglish language is fine, I didn’t detect any major flaws
Author Response
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Author Response File: Author Response.pdf
Reviewer 2 Report
Comments and Suggestions for AuthorsManuscript entitled"P16-CD8-Ki67 Triple Algorithm for Prediction of CDKN2A Mutations in Patients with Multiple Primary and Familial Melanoma"
1. IHC is semi-quantitative and is of large variety between labs. It is not an ideal way to perform three IHC as a screen tool.
2. The authors should include more cases, with sporadic or familiar cases.
3. The work can only be significance if the authors can test a wider cancer spectrum.
Comments on the Quality of English LanguageAcceptable
Author Response
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Author Response File: Author Response.pdf
Reviewer 3 Report
Comments and Suggestions for AuthorsThe manuscript by Nurla et al., entitled “ P16-CD8-Ki67 Triple Algorithm for Prediction of CDKN2A Mutations in Patients with Multiple Primary and Familial Melanoma “ is designed to evaluate the reliability of P16-CD8-Ki67 p16, CD8, and Ki67 individually serve as a predictive marker for multiple and familial primary melanomas with CDKN2A homozygous deletion. The manuscript is well written and the data are well presented Accordingly the manuscript can be published in the present Form.
Comments on the Quality of English LanguageThe english langauge is acceptable
Author Response
Please see the attachment.
Author Response File: Author Response.pdf
Round 2
Reviewer 2 Report
Comments and Suggestions for AuthorsApologize but there is no improvement made
Comments on the Quality of English LanguageAcceptable