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Article
Peer-Review Record

Endoscopic Ultrasound-Guided Fine Needle Biopsy in the Diagnostic Work-Up of Deep-Seated Lymphadenopathies and Spleen Lesions: A Monocentric Experience

Diagnostics 2023, 13(17), 2839; https://doi.org/10.3390/diagnostics13172839
by Flaminia Bellisario 1,2, Fabia Attili 3, Fabrizia Campana 2, Federica Borrelli de Andreis 3, Silvia Bellesi 1, Elena Maiolo 1, Eleonora Alma 1, Rosalia Malafronte 1,2, Giuseppe Macis 1, Luigi Maria Larocca 4, Salvatore Annunziata 1, Francesco D’Alò 1,2,* and Stefan Hohaus 1,2
Reviewer 1: Anonymous
Reviewer 2: Anonymous
Diagnostics 2023, 13(17), 2839; https://doi.org/10.3390/diagnostics13172839
Submission received: 13 June 2023 / Revised: 11 August 2023 / Accepted: 12 August 2023 / Published: 1 September 2023
(This article belongs to the Section Medical Imaging and Theranostics)

Round 1

Reviewer 1 Report

This study evaluated the diagnostic utility of fine needle biopsy of deep lymphadenopaties and spleen lesions. It is a single centre study and the authors report a sensitivity of FNB for diagnosing lymphomas to be more than 80 %. I have the following comments:

1.       In the introduction section the authors should discuss possible complications of FNB

2.       Does FNB increase the risk of malignant spread in certain tumour types?

3.       Why did the authors choose a period from June 2017 to December 2021?

4.       What were the exclusion criteria?

5.       The procedure of FNB should be described in greater detail

Author Response

Please see the attachment.

Author Response File: Author Response.docx

Reviewer 2 Report

Very interesting and well conducted study. My comments:

1) Sample size is good so no specific comment on that

2) The authors should comment on the important role of newer end-cutting FNB needles in EUS-guided tissue sampling (cite PMID: 35124072)

3) Follow-up of less than 1 year is not enough to represent the gold standard for accuracy in non-pancreatic lesions (check the AGA white paper)

 

Author Response

Please see the attachment

Author Response File: Author Response.docx

Round 2

Reviewer 2 Report

The revised version of the manuscript is OK. Thank you!

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