Impact of Pretreatment Ischemic Location on Functional Outcome after Thrombectomy
Abstract
:1. Introduction
2. Materials and Methods
2.1. Patient Selection and Clinical Assessment
2.2. Image Acquisition, Segmentation, and Normalization
2.3. Regional Ischemic Location Determination
2.4. Prediction Model Building
2.5. Statistical Analysis
3. Results
3.1. Patient Characteristics
3.2. Effect of Hemispheric Lateralization on Functional Outcome
3.3. Effect of Ischemic Topography on Functional Outcome
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Left Hemisphere (n = 74) | Right Hemisphere (n = 69) | p | |
---|---|---|---|
Age, years | 64 (52–74) | 68 (57–73) | 0.34 |
Sex, female/male | 31/43 | 28/41 | 0.99 |
Diabetes mellitus | 4/73 (5.48%) | 4/68 (5.88%) | 0.99 |
Hypertension | 33/74 (44.59%) | 33/67 (49.25%) | 0.70 |
Smoking (current or past) | 36/63 (57.14%) | 23/64 (35.94%) | 0.03 * |
Hypercholesterolemia | 34/62 (54.84%) | 26/63 (41.27%) | 0.18 |
Coronary disease | 7/70 (10.00%) | 10/67 (14.93%) | 0.54 |
History of stroke | 4/71 (5.63%) | 4/65 (6.15%) | 0.99 |
Admission glucose, g/L | 1.2 (1.0–1.5) | 1.2 (1.0–1.4) | 0.62 |
Baseline NIHSS score | 20 (18–22) | 15 (12–17) | 0.001 * |
Time from stroke onset to imaging, min | 113 (85–143) | 116 (93–127) | 0.65 |
Time from stroke onset to randomization, min | 173 (143–202) | 161 (142–183) | 0.13 |
Occlusion location, ICA: M1 | 10:64 | 5:64 | 0.34 |
ASPECT score | 7 (5–8) | 7 (6–8) | 0.04 * |
Fazekas score | 0 (0–1) | 1 (0–1) | 0.10 |
Functional outcome (mRS) | 2 (1–4) | 2 (1–4) | 0.33 |
Favorable functional outcome (mRS ≤ 2) | 40/74 (54.05%) | 42/69 (60.87%) | 0.51 |
Ischemic volume, mL | 21.58 (11.14–54.39) | 19.20 (10.24–32.65) | 0.51 |
Model | LogReg-Mp3 | LogReg-Mp4 | SVM-Mp3 | SVM-Mp4 |
---|---|---|---|---|
Accuracy (Mean ± SD) | 0.70 ± 0.01 | 0.73 ± 0.01 | 0.71 ± 0.02 | 0.77 ± 0.01 |
Sensitivity (Mean ± SD) | 0.60 ± 0.01 | 0.64 ± 0.02 | 0.60 ± 0.03 | 0.66 ± 0.03 |
PPV (Mean ± SD) | 0.66 ± 0.02 | 0.71 ± 0.02 | 0.68 ± 0.02 | 0.77 ± 0.02 |
NPV (Mean ± SD) | 0.72 ± 0.01 | 0.75 ± 0.01 | 0.72 ± 0.02 | 0.77 ± 0.01 |
AUC (Mean ± SD) | 0.77 ± 0.01 | 0.78 ± 0.01 | 0.77 ± 0.01 | 0.82 ± 0.01 |
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Xie, Y.; Oster, J.; Micard, E.; Chen, B.; Douros, I.K.; Liao, L.; Zhu, F.; Soudant, M.; Felblinger, J.; Guillemin, F.; et al. Impact of Pretreatment Ischemic Location on Functional Outcome after Thrombectomy. Diagnostics 2021, 11, 2038. https://doi.org/10.3390/diagnostics11112038
Xie Y, Oster J, Micard E, Chen B, Douros IK, Liao L, Zhu F, Soudant M, Felblinger J, Guillemin F, et al. Impact of Pretreatment Ischemic Location on Functional Outcome after Thrombectomy. Diagnostics. 2021; 11(11):2038. https://doi.org/10.3390/diagnostics11112038
Chicago/Turabian StyleXie, Yu, Julien Oster, Emilien Micard, Bailiang Chen, Ioannis K. Douros, Liang Liao, François Zhu, Marc Soudant, Jacques Felblinger, Francis Guillemin, and et al. 2021. "Impact of Pretreatment Ischemic Location on Functional Outcome after Thrombectomy" Diagnostics 11, no. 11: 2038. https://doi.org/10.3390/diagnostics11112038