Bridging the Species Gap: Morphological and Molecular Comparison of Feline and Human Intestinal Carcinomas
Abstract
:Simple Summary
Abstract
1. Introduction
2. Materials and Methods
2.1. Feline Study Cohort
2.1.1. Tissue Processing
2.1.2. Histomorphological Characterization
2.1.3. Semiquantitative Evaluation and Computer-Assisted Image Analysis
2.1.4. Sanger Sequencing of Feline CTNNB1 Exon 2
2.2. Human Specimen
2.3. Statistical Analysis
3. Results
3.1. Tumor Site and Frequency
3.2. Distribution of Histopathological Subtypes of the Feline Intestinal Tumor Cohort
3.3. Histopathological Features of Feline Intestinal Tumor Subtypes
3.4. Immunohistochemical Features of the Feline Intestinal Tumor Cohort
3.5. β-Catenin Gene Mutations in Exon 2 of Feline CTNNB1
3.6. Comparison of Feline Small Intestinal and Colonic Neoplasias
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Cohort | Subtype | n | % of Total |
---|---|---|---|
Histological Subtypes (Overall Cohort, n = 49) | ANOS | 29 | 59.18 |
SAC | 13 | 26.53 | |
MAC | 5 | 10.20 | |
MPC | 1 | 2.04 | |
SRCC | 1 | 2.04 | |
Histological Subtype (Small Intestinal, n = 16) | ANOS | 12 | 75.00 |
SAC | 1 | 6.25 | |
MAC | 2 | 12.5 | |
MPC | 1 | 6.25 | |
Histological Subtype (Colonic, n = 33) | ANOS | 17 | 51.52 |
SAC | 12 | 36.36 | |
MAC | 3 | 9.09 | |
SRCC | 1 | 3.03 |
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Groll, T.; Schopf, F.; Denk, D.; Mogler, C.; Schwittlick, U.; Aupperle-Lellbach, H.; Sarker, S.R.J.; Pfarr, N.; Weichert, W.; Matiasek, K.; et al. Bridging the Species Gap: Morphological and Molecular Comparison of Feline and Human Intestinal Carcinomas. Cancers 2021, 13, 5941. https://doi.org/10.3390/cancers13235941
Groll T, Schopf F, Denk D, Mogler C, Schwittlick U, Aupperle-Lellbach H, Sarker SRJ, Pfarr N, Weichert W, Matiasek K, et al. Bridging the Species Gap: Morphological and Molecular Comparison of Feline and Human Intestinal Carcinomas. Cancers. 2021; 13(23):5941. https://doi.org/10.3390/cancers13235941
Chicago/Turabian StyleGroll, Tanja, Franziska Schopf, Daniela Denk, Carolin Mogler, Ulrike Schwittlick, Heike Aupperle-Lellbach, Sabrina Rim Jahan Sarker, Nicole Pfarr, Wilko Weichert, Kaspar Matiasek, and et al. 2021. "Bridging the Species Gap: Morphological and Molecular Comparison of Feline and Human Intestinal Carcinomas" Cancers 13, no. 23: 5941. https://doi.org/10.3390/cancers13235941