Treatment Options and Post-Treatment Malignant Transformation Rate of Actinic Cheilitis: A Systematic Review
Abstract
:Simple Summary
Abstract
1. Introduction
2. Search Strategy
3. Data Extraction
4. Results
4.1. Therapies for AC
4.2. Outcomes
4.3. Therapeutic Response
4.4. Invasive Treatments
4.5. Non-Invasive Treatments
4.6. Cosmetic Outcome
4.7. Healing Time in Different Studies
4.8. Adverse Events
4.9. Post-Treatment Malignant Transformation
4.10. Assessment of Recurrence
5. Risk of Bias and Quality of the Shortlisted Studies
6. Discussion
7. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Conflicts of Interest
References
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Treatment | Number of Studies | Number of Patients | Specific Treatment | Days of Treatment | Follow-Up Time (Range in Months) |
---|---|---|---|---|---|
Partial surgery [23,29,50] | 3 | 28 | CO2 laser ablation, Electrodessication vs. CO2 laser, Chemical peel | 1 | 3–48 |
Laser [13,23,24,25,26,29,30,37,46,50,51,52] | 12 | 278 | CO2 laser, Er: YAG laser | 1–3 | 1.3–60 |
MAL PDT + 5%IMI [33] | 1 | 34 | - | 1 | 12 |
Laser-mediated PDT [30,31] | 2 | 33 | ALA-dye, MAL-Er: YAG | 1–3 | 1–12 |
FU [23,49,51] | 3 | 28 | 1% and 5% fluorouracil | 12–21 | 2–48 |
5% IMI [19,47] | 2 | 25 | - | 12–30 | 1–18 |
PDT [18,20,31,32,34,35,36,39,41,42,43,44,45] | 13 | 241 | Daylight PDT, ALA PDT, MAL PDT | 1–6 | 1–60 |
0.015% IngMeb [19,40] | 2 | 17 | - | 1 | 1–10 |
50%TCA [23] | 1 | 10 | - | 1 | 48 |
DHA [19,22,38,53] | 4 | 62 | - | 1 | 1–6 |
Treatment | Complete Response Rate (%) | Recurrence Rate (%) | Adverse Events | Excellent Cosmetic Results (%) | Discontinuation Rate (%) |
---|---|---|---|---|---|
Partial surgery [23,29,50] | 100 | 0.0 | Scarring | N/A | N/A |
Laser [13,23,24,25,26,29,30,37,46,50,51,52] | 93.39 | 6.42 | Scarring, pain, oedema, erosion, pruritus | 100.0 | N/A |
MAL PDT + 5%IMI [33] | 79.41 | 5.88 | Pain, erythema, burning sensation, scarring, oedema, pruritus, rash | N/A | 5.88 |
Laser-mediated PDT [30,31] | 75.76 | 6.10 | Erythema, burning sensation, oedema, erosions | N/A | N/A |
FU [23,49,51] | 75.0 | 31.80 | N/A | N/A | 10.0 |
5% IMI [19,47] | 76.0 | N/A | Erythema, oedema, induration, erosions, burning sensation | N/A | N/A |
PDT [18,20,31,32,34,35,36,39,41,42,43,44,45] | 66.67 | 14.07 | Pain, erythema, oedema, scaling, rash, erosions, burning sensation, scarring | 67.65 | 5.86 |
0.015% IngMeb [19,40] | 41.18 | 0.0 | Erythema, oedema, scaling, erosions, burning sensation | N/A | 0.0 |
50%TCA [23] | 30.0 | 70.0 | N/A | N/A | N/A |
DHA [19,22,38,53] | 45.16 | 6.52 | Erythema, oedema, burning sensation | 100.0 | 15.22 |
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Bakirtzi, K.; Papadimitriou, I.; Andreadis, D.; Sotiriou, E. Treatment Options and Post-Treatment Malignant Transformation Rate of Actinic Cheilitis: A Systematic Review. Cancers 2021, 13, 3354. https://doi.org/10.3390/cancers13133354
Bakirtzi K, Papadimitriou I, Andreadis D, Sotiriou E. Treatment Options and Post-Treatment Malignant Transformation Rate of Actinic Cheilitis: A Systematic Review. Cancers. 2021; 13(13):3354. https://doi.org/10.3390/cancers13133354
Chicago/Turabian StyleBakirtzi, Katerina, Ilias Papadimitriou, Dimitrios Andreadis, and Elena Sotiriou. 2021. "Treatment Options and Post-Treatment Malignant Transformation Rate of Actinic Cheilitis: A Systematic Review" Cancers 13, no. 13: 3354. https://doi.org/10.3390/cancers13133354