Cancer Immunotherapy and Application of Nanoparticles in Cancers Immunotherapy as the Delivery of Immunotherapeutic Agents and as the Immunomodulators
Abstract
:Simple Summary
Abstract
1. Introduction
2. Nanoparticles and Nanoparticles-Based Drug Delivery Systems
2.1. The Application of Nanoparticles in Cancer Immunotherapy
2.1.1. Nanoparticles as the Carrier of Immunotherapeutic Agents
2.1.2. Antigens and Adjuvants Delivery to Antigen Presenting Cells (APCs)
2.1.3. Antigens and Adjuvants Delivery to Tumor Microenvironment (TME)
2.1.4. Immune Checkpoint Inhibitors (ICIs) Delivery
2.1.5. Nanoparticles as the Direct Immunomodulators
3. Clinical Translation of Nano-Immunotherapy
4. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
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Compound Name | Formulation Description | Mechanism of Action | Clinical Trials | Approved by the FDA | Ref |
---|---|---|---|---|---|
RNA-LPX (Lipoplex®) | RNA-lipoplexes | DC maturation, T cell response | Phase I (2016) | [82] | |
MRX34 | miRNA-34a-loaded liposome | Downregulation of immune evasion tumor genes | Phase I (2016) | [183] | |
mRNA-4157 | mRNA-4157 encapsulated in Lipids | induce neoantigen specific T cells and associated anti-tumor responses. | Phase I (2019) | [184] | |
Ferumoxytol (Ferahem®) | Iron oxide nanoparticles (IONP) | M2 Macrophage polarization to M1-like | Yes, for anemia and kidney diseases | [185] | |
PTX-LDE | Paclitaxel-loaded lipid core NPs | DC maturation | Phase II (2017) | [186,187] | |
Anti-EGFR-IL-dox | Doxorubicin-loaded anti-EGFR immunoliposomes | Block EGFR-mediated growth signaling and induce immunogenic cell death | Phase II (2016) | NCT02833766 | |
JVRS-100 | Cationic liposome incorporating plasmid DNA complex | Immune system stimulation | Phase I (2016) | NCT00860522 | |
NBTXR3 | Hafnium oxide nanoparticles in combination with anti-PD1 | Enhance tumor cell death via electron production, induce immunogenic cell death leading to activation of the immune system | Phase I (2019) | [188], NCT03589339 |
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Debele, T.A.; Yeh, C.-F.; Su, W.-P. Cancer Immunotherapy and Application of Nanoparticles in Cancers Immunotherapy as the Delivery of Immunotherapeutic Agents and as the Immunomodulators. Cancers 2020, 12, 3773. https://doi.org/10.3390/cancers12123773
Debele TA, Yeh C-F, Su W-P. Cancer Immunotherapy and Application of Nanoparticles in Cancers Immunotherapy as the Delivery of Immunotherapeutic Agents and as the Immunomodulators. Cancers. 2020; 12(12):3773. https://doi.org/10.3390/cancers12123773
Chicago/Turabian StyleDebele, Tilahun Ayane, Cheng-Fa Yeh, and Wen-Pin Su. 2020. "Cancer Immunotherapy and Application of Nanoparticles in Cancers Immunotherapy as the Delivery of Immunotherapeutic Agents and as the Immunomodulators" Cancers 12, no. 12: 3773. https://doi.org/10.3390/cancers12123773