Satellitosis, a Crosstalk between Neurons, Vascular Structures and Neoplastic Cells in Brain Tumours; Early Manifestation of Invasive Behaviour
Abstract
:Simple Summary
Abstract
1. Introduction
2. Satellitosis in Neurological Disease
2.1. Histological Characterisation of Perineuronal Satellitosis in Brain Tumours
2.2. Molecular Mechanisms Involved in Perineuronal Satellitosis Phenomena
2.3. Histological Characterisation of Perivascular Satellitosis in Brain Tumours
2.4. Molecular Mechanisms Involved in Perivascular Satellitosis Phenomenon
3. Concluding Remarks
Author Contributions
Funding
Conflicts of Interest
References
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Experimental Models | Molecular Mechanism Proposed | References |
---|---|---|
Human Tissue sample and Animals | (First evidence) Histological visualisation
| [1,2,3,4,5,6,8,9,11,13] |
Human Tissue sample | Metabolic exchange and migration
| [41] |
Animals (in vitro, in vivo) | Chemotactic attraction and migration
| [46,47] |
Animals In vivo, in vitro Patient derived GB cells | Metabolic exchange and spared within brain parenchyma
| [29,51,52,53] |
Human In vivo; in vitro Patient derived GB cells | Neuronal activity on glioma promotion
| [66,68,69,70] |
Experimental Models | Molecular Mechanism Proposed | References |
---|---|---|
Human, Animals in vivo | First histological description
| [8,12] |
Animals (in vitro cells, in vivo) | GB cells interact with BBB:
| [80] |
Animals (in vitro cells, in vivo) | Mechanism of Individual co-option and Collective co-option:
| [80,81] |
Animals (In vivo cell lines) | Vascular recruitment
| [88,89] |
Human /Animal (In vivo; in vitro Patient-derived-GB, Tissue sample) | Chemotactic attraction and invasion
| [90,91,92,93,94,95,96] |
Human/Animals In vivo; in vitro | GB cell/pericyte fusion-hybrids
| [86] |
Human In vivo cellls; in vitro | Surrounding microvasculature and migration
| [85] |
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Civita, P.; Valerio, O.; Naccarato, A.G.; Gumbleton, M.; Pilkington, G.J. Satellitosis, a Crosstalk between Neurons, Vascular Structures and Neoplastic Cells in Brain Tumours; Early Manifestation of Invasive Behaviour. Cancers 2020, 12, 3720. https://doi.org/10.3390/cancers12123720
Civita P, Valerio O, Naccarato AG, Gumbleton M, Pilkington GJ. Satellitosis, a Crosstalk between Neurons, Vascular Structures and Neoplastic Cells in Brain Tumours; Early Manifestation of Invasive Behaviour. Cancers. 2020; 12(12):3720. https://doi.org/10.3390/cancers12123720
Chicago/Turabian StyleCivita, Prospero, Ortenzi Valerio, Antonio Giuseppe Naccarato, Mark Gumbleton, and Geoffrey J. Pilkington. 2020. "Satellitosis, a Crosstalk between Neurons, Vascular Structures and Neoplastic Cells in Brain Tumours; Early Manifestation of Invasive Behaviour" Cancers 12, no. 12: 3720. https://doi.org/10.3390/cancers12123720