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Hematology Reports
Volume 5
Issue 3
10.4081/hr.2013.e12
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Hematology Reports is published by MDPI from Volume 14 Issue 1 (2022). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with PAGEPress.
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Case Report

Ventricular Fibrillation after Bortezomib Therapy in a Patient with Systemic Amyloidosis

by
Satoshi Yamasaki
1,2,*,
Tsuyoshi Muta
1,
Taiki Higo
3,
Hirotake Kusumoto
1,
Eiko Zaitsu
3,
Toshihiro Miyamoto
1,
Yoshinao Oda
4 and
Koichi Akashi
1
1
Department of Medicine and Biosystemic Sciences, School of Medical Sciences, Kyushu University, Fukuoka, Japan
2
Department of Hematology, National Hospital Organization Kyushu Medical Center, 1-8-1 Jigyohama, Chuo- ku, Fukuoka 810-8563, Japan
3
Department of Cardiovascular Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan
4
Department of Anatomic Pathology, Faculty of Medicine, Kyushu University, Fukuok, Japan
*
Author to whom correspondence should be addressed.
Hematol. Rep. 2013, 5(3), e12; https://doi.org/10.4081/hr.2013.e12
Submission received: 23 May 2013 / Revised: 26 June 2013 / Accepted: 25 July 2013 / Published: 16 September 2013

Abstract

A 64-year-old female was diagnosed with systemic amyloidosis associated with multiple myeloma. Bortezomib and dexamethasone-therapy was initiated; however, she developed lethal ventricular fibrillation (VF) and cardiac arrest after 84 h of therapy. Cardiopulmonary resuscitation using direct current shocks with epinephrine and amiodarone was initiated but failed to receive cardiac function. Although her arterial pulsations recovered immediately after the injection of vasopressin, she died of heart failure 8 h after the onset of VF. Cardiac amyloidosis was verified by autopsy. Although the direct association of bortezomib with lethal VF remained to be clarified in our patient, the current report emphasizes on bortezomib as a substantial risk factor for cardiomyocyte damage. The potential risk of lethal events associated with cardiac amyloidosis should be carefully considered during bortezomib treatment for patients with AL amyloidosis.
Keywords: systemic amyloidosis; multiple myeloma; ventricular fibrillation; bortezomib systemic amyloidosis; multiple myeloma; ventricular fibrillation; bortezomib

Share and Cite

MDPI and ACS Style

Yamasaki, S.; Muta, T.; Higo, T.; Kusumoto, H.; Zaitsu, E.; Miyamoto, T.; Oda, Y.; Akashi, K. Ventricular Fibrillation after Bortezomib Therapy in a Patient with Systemic Amyloidosis. Hematol. Rep. 2013, 5, e12. https://doi.org/10.4081/hr.2013.e12

AMA Style

Yamasaki S, Muta T, Higo T, Kusumoto H, Zaitsu E, Miyamoto T, Oda Y, Akashi K. Ventricular Fibrillation after Bortezomib Therapy in a Patient with Systemic Amyloidosis. Hematology Reports. 2013; 5(3):e12. https://doi.org/10.4081/hr.2013.e12

Chicago/Turabian Style

Yamasaki, Satoshi, Tsuyoshi Muta, Taiki Higo, Hirotake Kusumoto, Eiko Zaitsu, Toshihiro Miyamoto, Yoshinao Oda, and Koichi Akashi. 2013. "Ventricular Fibrillation after Bortezomib Therapy in a Patient with Systemic Amyloidosis" Hematology Reports 5, no. 3: e12. https://doi.org/10.4081/hr.2013.e12

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