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Cardiogenetics
Volume 2
Issue 1
10.4081/cardiogenetics.2012.e12
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Review

The Novel Role of Epigenetics in Primary Prevention of Cardiovascular Diseases

by
Claudio Napoli
1,2,3,*,
Amelia Casamassimi
1,
Vincenzo Grimaldi
2,
Concetta Schiano
1,
Teresa Infante
3,
Alberto Zullo
4,5,
Maria Lourdes Montesano
2,
Laura Auriemma
2,
Francesco Paolo De Luca
2,
Gustavo De Iorio
2,
Louis J. Ignarro
6 and
Francesco Paolo Mancini
4,7
1
Department of General Pathology, Division of Clinical Pathology and Excellence Research Centre on Cardiovascular Disease, 1st School of Medicine, Second University of Naples, Italy
2
U.O.C. Immunohematology, Transfusion Medicine and Transplant Immunology (SIMT), Regional Reference Laboratory of Transplant Immunology (LIT), 1st School of Medicine, Second University of Naples, Italy
3
Foundation SDN, IRCCS, Naples, Italy
4
Department of Science for Biology, Geology and Environment, University of Sannio, Benevento, Italy
5
CEINGE Biotecnologie Avanzate s.c.a r.l., Naples, Italy
6
Department of Molecular and Medical Pharmacology, UCLA School of Medicine, Center for the Health Sciences, Los Angeles, CA, USA
7
Department of Biochemistry and Medical Biotechnology, University of Naples “Federico II”, Naples, Italy
*
Author to whom correspondence should be addressed.
Cardiogenetics 2012, 2(1), e12; https://doi.org/10.4081/cardiogenetics.2012.e12
Submission received: 30 July 2012 / Revised: 12 October 2012 / Accepted: 14 October 2012 / Published: 19 November 2012

Abstract

A great deal of evidences indicate that impaired fetal growth and in utero exposure to risk factors, especially maternal hypercholesterolemia, may be relevant for human pathophysiological signs of atherosclerosis and subsequent development of cardiovascular disease (CVD) during different life stages. Despite the underlying mechanisms of fetal programming are still unknown, epigenetics has been suggested as one of the possible explanations for the associations between intrauterine risk factors and CVD development. Indeed, a lot of translational studies support the hypothesis that epigenetic changes are related to increased CVD risk although it is still not possible to establish a direct causality in humans. Notably, epigenetic modifications can be reversible through therapeutic approaches employing histone deacetylase inhibitors, histone acetyltransferase inhibitors and commonly used drugs like statins. Thus, the whole comprehension of these mechanisms will provide in the next future the rationale for the development of novel tools to be used in the primary prevention and therapy of CVD.
Keywords: epigenetics; cardiovascular disease; primary prevention; hypercholesterolemia; novel risk factors epigenetics; cardiovascular disease; primary prevention; hypercholesterolemia; novel risk factors

Share and Cite

MDPI and ACS Style

Napoli, C.; Casamassimi, A.; Grimaldi, V.; Schiano, C.; Infante, T.; Zullo, A.; Montesano, M.L.; Auriemma, L.; De Luca, F.P.; De Iorio, G.; et al. The Novel Role of Epigenetics in Primary Prevention of Cardiovascular Diseases. Cardiogenetics 2012, 2, e12. https://doi.org/10.4081/cardiogenetics.2012.e12

AMA Style

Napoli C, Casamassimi A, Grimaldi V, Schiano C, Infante T, Zullo A, Montesano ML, Auriemma L, De Luca FP, De Iorio G, et al. The Novel Role of Epigenetics in Primary Prevention of Cardiovascular Diseases. Cardiogenetics. 2012; 2(1):e12. https://doi.org/10.4081/cardiogenetics.2012.e12

Chicago/Turabian Style

Napoli, Claudio, Amelia Casamassimi, Vincenzo Grimaldi, Concetta Schiano, Teresa Infante, Alberto Zullo, Maria Lourdes Montesano, Laura Auriemma, Francesco Paolo De Luca, Gustavo De Iorio, and et al. 2012. "The Novel Role of Epigenetics in Primary Prevention of Cardiovascular Diseases" Cardiogenetics 2, no. 1: e12. https://doi.org/10.4081/cardiogenetics.2012.e12

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