4-Aminoquinoline-Based Adamantanes as Potential Anticholinesterase Agents in Symptomatic Treatment of Alzheimer’s Disease
, Suzana Žunec 2, Sandra Šegan 3, Mario Zlatović 1, Nikola Maraković 2, Anita Bosak 2,* and Dejan M. Opsenica 3,4,*
Round 1
Reviewer 1 Report
The authors should discuss ferroptosis, which has been implicated as a mechanism of cell death in AD. As the compounds have antioxidant activity, it would be interesting if the authors write how these compounds could be a therapeutic candidate for ferroptosis leading to neurodegeneration.
Author Response
Response to Reviewer 1 comments:
The authors would like to thank Reviewer 1 for her/his valuable comments on our manuscript. We have responded to all of the comments and revised the paper accordingly.
Comment: The authors should discuss ferroptosis, which has been implicated as a mechanism of cell death in AD. As the compounds have antioxidant activity, it would be interesting if the authors write how these compounds could be a therapeutic candidate for ferroptosis leading to neurodegeneration.
Response: The discussion of ferroptosis was added in the General Discussion section.
“Considerable antioxidant power of compounds 17, 18 and 19 to attenuate adverse effects of oxidative stress associated with AD could be considered as an additional target in terms of the design and development of 4-aminoquinolines as multi target drugs. This is especially interesting in terms of the ferroptosis, an iron-dependent mechanism of regulated cell death associated with the increase in oxidative stress generated by free radicals formed via the Fenton reaction. Due to its correlation to the etiopathology of AD, ferroptosis is proposed as a promising new target for the treatment of AD [72].”
Reviewer 2 Report
The manuscript is significantly improved, but the English should be revised by an English mother language reader.
Author Response
Response to Reviewer 2 comments:
The authors would like to thank Reviewer 2 for her/his valuable comment on our manuscript. We have responded to the comment and revised the paper accordingly.
Comment: The manuscript is significantly improved, but the English should be revised by an English mother language reader.
Response: the manuscript was additionally revised by English nature speaker, Mrs Lynn Katsikas. All the changes are marked by Track changes.
