The Influence of Organic Vanadium Complexes on an Antioxidant Profile in Adipose Tissue in Wistar Rats
Abstract
:1. Introduction
2. Materials and Methods
2.1. Reagents
2.2. Synthesis of Vanadium Complexes
2.3. Animals
2.4. Sample Collection and Analysis
2.5. Measurement of the Vanadium Content in Adipose Tissue
2.6. Relative Change of Rat Weight
2.7. Basal Metabolic Rate
2.8. Measurement of the Total Antioxidant Capacity—Ferric Reducing Antioxidant Power (FRAP)
2.9. Measurement of Glutathione (GSH) Concentration
2.10. Measurement of Catalase (CAT) Activity
2.11. Measurement of Superoxide Dismutase (SOD) Activity
2.12. Statistical Analysis
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
Abbreviations
V complex | sodium (2,2′-bipyridine)oxidobisperoxovanadate (V) octahydrate |
B complex | bis(2,2′-bipyridine)oxidovanadium(IV) sulfate dehydrate |
BM complex | bis(4,4′-dimethyl-2,2′-bipyridine)oxidovanadium (IV) sulfate dehydrate |
CN | standard diet without additives |
CV | V complex with standard diet |
CB | B complex with standard diet |
CBM | BM complex with standard diet |
FN | high-fat diet without additives |
FV | V complex with high-fat diet |
FB | B complex with high-fat diet |
FBM | BM complex with high-fat diet |
∆rw | relative change in rat weight |
References
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Animal Group | Water Intake ± SD [mL/Day/Animal] | Feed Intake ± SD [g/Day/Animal] | BWG ± SD [g/Animal] | BMR ± SD [kcal/g Body Weight Gain] | VI ± SD [mg/kg/day] | VCAT ± SD [μg/kg of Dry Adipose Tissue] |
---|---|---|---|---|---|---|
CN | 27.0 ± 4.9 a | 18.4 ± 4.9 b | 105.3 ± 13.9 a | 21.0 ± 0.3 a | ND | 0.81 ± 0.09 a |
CV | 30.3 ± 5.2 a | 17.3 ± 1.9 b | 96.8 ± 18.3 a | 22.6 ± 0.2 b | 2.25 ± 0.2 a | 3.48 ± 0.37 b |
CB | 26.6 ± 2.5 a | 17.7 ± 3.6 b | 83.5 ± 15.4 ab | 26.1 ± 0.6 c | 1.99 ± 0.2 a | 3.67 ± 0.22 b |
CBM | 28.0 ± 5.2 a | 17.9 ± 1.5 b | 76.8 ± 15.1 b | 27.6 ± 0.1 c | 1.80 ± 0.2 a | 4.02 ± 0.31 b |
FN | 25.6 ± 3.6 a | 13.5 ± 0.8 a | 109.7 ± 21.5 a | 19.8 ± 1.2 a | ND | 0.78 ± 0.12 a |
FV | 24.5 ± 3.8 a | 11.9 ± 2.2 a | 78.3 ± 14.1 b | 24.7 ± 1.0 b | 2.25 ± 0.2 a | 3.55 ± 0.29 b |
FB | 29.2 ± 8.1 a | 12.3 ± 2.4 a | 95.6 ± 21.1 a | 23.1 ± 2.9 b | 1.99 ± 0.2 a | 3.53 ± 0.31 b |
FBM | 29.6 ± 6.6 a | 13.3 ± 2.4 a | 94.5 ± 24.6 a | 24.6 ± 1.0 b | 1.80 ± 0.2 a | 4.19 ± 0.30 b |
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Francik, R.; Kryczyk-Kozioł, J.; Krośniak, M.; Francik, S.; Hebda, T.; Pedryc, N.; Knapczyk, A.; Berköz, M.; Ślipek, Z. The Influence of Organic Vanadium Complexes on an Antioxidant Profile in Adipose Tissue in Wistar Rats. Materials 2022, 15, 1952. https://doi.org/10.3390/ma15051952
Francik R, Kryczyk-Kozioł J, Krośniak M, Francik S, Hebda T, Pedryc N, Knapczyk A, Berköz M, Ślipek Z. The Influence of Organic Vanadium Complexes on an Antioxidant Profile in Adipose Tissue in Wistar Rats. Materials. 2022; 15(5):1952. https://doi.org/10.3390/ma15051952
Chicago/Turabian StyleFrancik, Renata, Jadwiga Kryczyk-Kozioł, Mirosław Krośniak, Sławomir Francik, Tomasz Hebda, Norbert Pedryc, Adrian Knapczyk, Mehmet Berköz, and Zbigniew Ślipek. 2022. "The Influence of Organic Vanadium Complexes on an Antioxidant Profile in Adipose Tissue in Wistar Rats" Materials 15, no. 5: 1952. https://doi.org/10.3390/ma15051952