Communication between Bone Marrow Niches in Normal Bone Marrow Function and during Hemopathies Progression
Centro de Investigação de Patobiologia Molecular, CIPM, Instituto Português de Oncologia de Lisboa Francisco Gentil, E.P.E., R. Professor Lima Basto, 1099-023 Lisboa, Portugal
CEDOC, Faculdade de Ciências Médicas, Universidade Nova de Lisboa, 1099-085 Lisboa, Portugal
Instituto Gulbenkian Ciência, 2780-156 Oeiras, Portugal
Author to whom correspondence should be addressed.
Hematol. Rev. 2009, 1(2), e14; https://doi.org/10.4081/hr.2009.e14 (registering DOI)
Original submission received: 26 May 2009
Revised: 26 July 2009
Accepted: 27 July 2009
Published: 28 August 2009
Hematopoietic stem cell (HSC) chemotaxis, adhesion, proliferation, quiescence and differentiation are regulated by interactions with bone marrow (BM) niches. Two niches have been identified in the adult BM: the endosteal (close to the bone) and the perivascular niche (close to blood vessels). A vast body of literature has revealed the molecular basis for the interaction of HSCs with the two niches. However, the signals that regulate the communication between the two niches have not been well defined. Taking in consideration several clinical and experimental arguments this review highlights the molecular cues, involved in the communication between the BM niches, which regulate the basic properties of HSCs in physiological and malignant conditions. As such, it aims at clarifying the most important advances in basic and clinical research focusing on the role of different factors in the regulation of the BM microenvironment.
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Lamorte, S.; Remédio, L.; Dias, S.
Communication between Bone Marrow Niches in Normal Bone Marrow Function and during Hemopathies Progression. Hematol. Rev. 2009, 1, e14.
Lamorte S, Remédio L, Dias S.
Communication between Bone Marrow Niches in Normal Bone Marrow Function and during Hemopathies Progression. Hematology Reviews. 2009; 1(2):e14.
Lamorte, Sara, Leonor Remédio, and Sergio Dias.
2009. "Communication between Bone Marrow Niches in Normal Bone Marrow Function and during Hemopathies Progression" Hematology Reviews 1, no. 2: e14.
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