MicroRNAs: Tiny Players with a Big Role in the Pathogenesis of Leukemias and Lymphomas
Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori, 47014 Meldola, Italy
Department of Molecular Virology, Immunology, and Medical Genetics and Comprehensive Cancer Center, Ohio State University, Columbus, OH 43210, USA
Author to whom correspondence should be addressed.
Hematol. Rev. 2009, 1(1), e8; https://doi.org/10.4081/hr.2009.e8 (registering DOI)
Original submission received: 29 April 2009
Revised: 1 May 2009
Accepted: 5 May 2009
Published: 14 May 2009
MicroRNAs (miRNAs) are small non-coding RNAs (ncRNAs) with important regulatory functions. After an initial phase, aimed at identifying whether a deregulation in miRNA expression occurred between hematologic malignancies and their normal counterparts, currently an increasing number of studies are focusing on the functional significance of these aberrancies. The identification of miRNA targeted genes has cast a new light on the role of these tiny ncRNAs in human cancerogenesis, providing a new rationale to the observed diagnostic, prognostic and therapeutic implications of miRNA aberrant expression in human hematologic malignancies.
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Fanini, F.; Vannini, I.; Fabbri, M.
MicroRNAs: Tiny Players with a Big Role in the Pathogenesis of Leukemias and Lymphomas. Hematol. Rev. 2009, 1, e8.
Fanini F, Vannini I, Fabbri M.
MicroRNAs: Tiny Players with a Big Role in the Pathogenesis of Leukemias and Lymphomas. Hematology Reviews. 2009; 1(1):e8.
Fanini, Francesca, Ivan Vannini, and Muller Fabbri.
2009. "MicroRNAs: Tiny Players with a Big Role in the Pathogenesis of Leukemias and Lymphomas" Hematology Reviews 1, no. 1: e8.
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