Next Article in Journal
Why We Still Need Reliable Animal Models
Previous Article in Journal
The Renaissance of Pathophysiology—The Flagship Journal of the International Society for Pathophysiology
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Pathophysiology
Volume 27
Issue 1
10.3390/pathophysiology27010005
Review Report
pathophysiology-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
Article
Peer-Review Record

Systemic Action of Inflammatory Mediators in Patients with Essential Hypertension and Diastolic Chronic Heart Failure: A Clinical Pathophysiological Study

Pathophysiology 2020, 27(1), 30-43; https://doi.org/10.3390/pathophysiology27010005
by Anton V. Barsukov 1,*, Alla Yu. Seidova 2, Ksenia A. Shcherbakova 1, Marina S. Black 1, Alexander E. Korovin 1,3, Leonid P. Churilov 3,4 and Dmitry V. Tovpeko 1
Reviewer 1: Anonymous
Reviewer 2: Anonymous
Pathophysiology 2020, 27(1), 30-43; https://doi.org/10.3390/pathophysiology27010005
Submission received: 4 November 2020 / Revised: 4 December 2020 / Accepted: 10 December 2020 / Published: 12 December 2020

Round 1

Reviewer 1 Report

I read "Systemic action of inflammatory mediators in patients with essential hypertension and diastolic chronic heart failure: clinical pathophysiological study" with great intres, nonetheless I have some concerns:

1) This Journal has world wide range, please use European  Society of Cardiology (ESC) or American Heart Association (AHA) classifications and definitions. 

2) Please define degrees of heart failure?  New York Heart Association scale (NYHA) is used worldwide. Please convert.

3) I can not understand study flow. Is this prospective study or retrospective registry study? Please add figure with study flow. One picture is wotrth more than 1000 words.

4) In exlusion criteria I can see valvular heart disease- please define. Mild MR or TR disqualifies patients form the study?

5) Please clarify how many female subjects  were  in post- menopausal. This is quite crucial for the study (10.3390/jcm8060792)

5) In statistical analysis I can not find do Authors used non-paremtric test for skewed distribution?

6) Dissusion is very long. I suggest to make it shorter, more condense and easer to read.

 7) I can not find any limitation of you study. Please add paragraph.

Author Response

Please see the attachment.

Author Response File: Author Response.docx

Reviewer 2 Report

The aim  of the study, as stated by the  authors,  was to establish a correlation relationship between indicators of pro-inflammatory status and the structural and functional characteristics of the cardiovascular system in patients with essencial arterial hypertension with diastolic complications as well as the differevce between genders.

The study would be strengthened by picture from echocardiograph such as trace of left ventricle, the trace from a pulse tissue Doppler sample placed at the valve or so.

Another minor question is about statistics. What kind of post-hoc test did authors use?

Did authors see functional differences between patients with 1st and 2nd degree of hypertension? If yes, should be stated.

Author Response

Please see the attachment.

Author Response File: Author Response.docx

Round 2

Reviewer 1 Report

Authors still use CHF classification. Please change to NYHA.

Back to TopTop