Photodynamic Therapy and Cardiovascular Diseases
Abstract
:1. Introduction
2. Characteristics of Cardiovascular Diseases
3. PDT Mechanism of Action
3.1. Photosensitizers Used in PDT in the Treatment of Cardiovascular Diseases
3.1.1. Hematoporphyrin
3.1.2. Photofrin®
3.1.3. Verteporfin
3.1.4. 5-Aminolevulinic Acid (5-ALA)
3.1.5. Phthalocyanine Derivatives
3.1.6. Motexafin Lutetium
3.1.7. Talaporfin Sodium
3.1.8. Indocyanine Green
3.2. An Antiatherogenic Photodynamic Therapy
4. Conclusions
- (1)
- A theranostic tool for the identification and regression of sensitive atherosclerotic plaques;
- (2)
- A therapeutic alternative in the prevention and treatment of restenosis.
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Photosensitizer | Structure of the Photosensitizer | Absorption Spectrum | Animal Model | Properties | References |
---|---|---|---|---|---|
Hematoporphyrin | 600–650 nm | Rabbits, monkeys | Selective accumulation in atherosclerotic plaques | [40,41,42] | |
Photofrin® | 615–635 nm | Rabbits, mini pigs, monkeys | The photosensitizer itself without photoactivation causes significantly reduced proliferative activity of VSMCs | [43,44,45,46] | |
Verteporfin | 660–700 nm | Mice, rabbits | Induces apoptosis after light activation by increasing the level of mitochondrial cytochrome c and apoptosis-inducing factors, and prevents neointimal hyperplasia | [47,48,49] | |
5-aminolevulinic acid (5-ALA) | ~635 nm | Rabbits, pigs | Significant reduction in VSMC numbers observed 28 days after stenting and reduction in atherosclerotic plaque in animal models | [50,51,52,53,54] | |
Phthalocyanine | 660–680 nm | Rats, rabbits | Effective prevention of IH for up to 6 months | [55,56,57] | |
Motexafin lutetium | 710–750 nm | Rabbits | Significant reduction in atherosclerotic lesions in coronary heart transplant disease, atherosclerotic peripheral arterial insufficiency | [58,59,60,61,62] | |
Talaporfin sodium | Rabbits | It specifically accumulates in atherosclerotic plaques, prevents neointimal hyperplasia and premature destruction of elastic fiber. | [63,64,65,66,67] | ||
Indocyanine green | 780 | Pigs, rabbits, rats | ICG is amphiphilic. It accumulates in inflammatory tissues. It has a small penetration depth. | [68,69,70,71,72] |
Macrophages Phenotype | Role in Atherosclerosis |
---|---|
Mox | Promote heme detoxification Reduce oxidative stress Inhibit foam cell formation |
M(Hb) | Scavenge free hemoglobin and prevent its pro-oxidative effects |
Mhem | Promote erythrocyte turnover by phagocytosing senescent and damaged erythrocytes, and recycle their iron and heme |
M4 | Recruit monocytes and neutrophils Degrade extracellular matrix proteins |
HAMac | Hemophagocytosis Produce high levels of proinflammatory cytokines and induce apoptosis of smooth muscle cells |
Steps | |
---|---|
A | Macrophages internalize LDL, VLDL and oxidized lipoproteins in the plaque. These processes are known as a macropinocytosi, phagocytosis or scavenger receptor A (SRA), LOX1, SRB1 and CD36 [103]. |
B | Lipoproteins and their associated lipids are digested in the lysosome. Cholesterol enters the cell membrane, and in the next step, cholesterol is removed from the cell or into the endoplasmic reticulum (ER) membrane. In the next step, is cholesterol is esterified by acyl-coA cholesterol acyltransferase (ACAT) and ultimately stored in this form in cytosolic lipid droplets [104]. |
C | Lipids can be mobilized for efflux via lipolysis by neutral cholesteryl ester hydrolases (nCEH) or lipophagy, a form of autophagy that results in the delivery of lipid droplets to lysosomes. [105] |
D | Cholesterol activates the heterodimeric hepatic X receptor (LXR)/retinoid) or more HDL particles in which the free cholesterol has been esterified and stored in the core of the particle (mature HDL) [106]. |
E | Cholesterol can induce the formation of cholesterol crystals in the lysosome to activate the NLRP3 inflammasome and can also interfere with ER function (ER stress), which, if prolonged, causes cell death by apoptosis, and the lipid rafts are enriched in sphingomyelin, which forms a complex with free cholesterol [107]. |
F | As the cholesterol content increases in lipid rafts, proinflammatory Toll-like receptor 4 (TLR4) signaling is promoted, which can also be induced by an oxidized low-density lipoprotein (LDL) via a heterotrimeric complex composed of CD36–TLR4–TLR6. This signaling resultd in the activation of nuclear factor-κB (NF-κB) and the production of proinflammatory cytokines and chemokines [108]. |
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Oskroba, A.; Bartusik-Aebisher, D.; Myśliwiec, A.; Dynarowicz, K.; Cieślar, G.; Kawczyk-Krupka, A.; Aebisher, D. Photodynamic Therapy and Cardiovascular Diseases. Int. J. Mol. Sci. 2024, 25, 2974. https://doi.org/10.3390/ijms25052974
Oskroba A, Bartusik-Aebisher D, Myśliwiec A, Dynarowicz K, Cieślar G, Kawczyk-Krupka A, Aebisher D. Photodynamic Therapy and Cardiovascular Diseases. International Journal of Molecular Sciences. 2024; 25(5):2974. https://doi.org/10.3390/ijms25052974
Chicago/Turabian StyleOskroba, Aleksander, Dorota Bartusik-Aebisher, Angelika Myśliwiec, Klaudia Dynarowicz, Grzegorz Cieślar, Aleksandra Kawczyk-Krupka, and David Aebisher. 2024. "Photodynamic Therapy and Cardiovascular Diseases" International Journal of Molecular Sciences 25, no. 5: 2974. https://doi.org/10.3390/ijms25052974