Epstein–Barr Virus and Human Endogenous Retrovirus in Japanese Patients with Autoimmune Demyelinating Disorders
Abstract
:1. Introduction
2. Results
2.1. Humoral Response to EBNA1386–405 Peptide in Patients with MS, MOGAD, NMOSD, and Healthy Controls
2.2. Antibody Response to HERV-W486–504 Peptide in Patients with MS, MOGAD, NMOSD, and Healthy Controls
3. Discussion
4. Materials and Methods
4.1. Patients
4.2. Synthetic Peptides
4.3. Peptide-Based Indirect Enzyme-Linked Immunosorbent Assays (ELISA)
4.4. Epstein–Barr Virus EBNA1 ELISA
4.5. Statistics
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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MS (34) | NMOSD (20) | MOGAD (20) | HCs (40) | |
---|---|---|---|---|
Gender female/male | 26/8 | 15/5 | 14/6 | 30/10 |
Age (years) mean ± SD | 40 ± 9 | 45 ± 16 | 39 ± 10 | 44 ± 15 |
Age at onset (years) mean ± SD | 32 ± 8 | 43 ± 14 | 32 ± 10 | 0 |
Disease duration (years) mean ± SD | 7 ± 6 | 8 ± 7 | 6 ± 4 | 0 |
EDSS score mean ± SD | 2 ± 2 | 4 ± 2 | 3 ± 3 | 0 |
Anti-AQP4 IgG (% positive) | 0 | 60 | 0 | 0 |
Anti-MOG IgG (% positive) | 0 | 0 | 100 | 0 |
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Cossu, D.; Tomizawa, Y.; Sechi, L.A.; Hattori, N. Epstein–Barr Virus and Human Endogenous Retrovirus in Japanese Patients with Autoimmune Demyelinating Disorders. Int. J. Mol. Sci. 2023, 24, 17151. https://doi.org/10.3390/ijms242417151
Cossu D, Tomizawa Y, Sechi LA, Hattori N. Epstein–Barr Virus and Human Endogenous Retrovirus in Japanese Patients with Autoimmune Demyelinating Disorders. International Journal of Molecular Sciences. 2023; 24(24):17151. https://doi.org/10.3390/ijms242417151
Chicago/Turabian StyleCossu, Davide, Yuji Tomizawa, Leonardo Antonio Sechi, and Nobutaka Hattori. 2023. "Epstein–Barr Virus and Human Endogenous Retrovirus in Japanese Patients with Autoimmune Demyelinating Disorders" International Journal of Molecular Sciences 24, no. 24: 17151. https://doi.org/10.3390/ijms242417151