Natural Chalcones for the Management of Obesity Disease
Abstract
:1. Introduction
2. In Vitro Evidence
2.1. Cardamonin
2.2. Licochalcone A
2.3. Butein
2.4. Panduratin A
2.5. Isoliquiritigenin
2.6. Xanthohumol
2.7. Others
3. In Vivo Studies
3.1. Cardamonin Derivatives
3.2. Butein
3.3. Licochalcone A
3.4. Licochalcone E
3.5. Panduratin A
3.6. Isoliquiritigenin
3.7. Xanthohumol
4. Materials and Methods
Search Strategy
5. Conclusions
Author Contributions
Funding
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Chalcone | Cell Model | Dose | Mechanism | Ref. |
---|---|---|---|---|
Cardamomin | 3T3-L1 | 10 or 30 µM | PPARγ ↓, FABP4 ↓, C/EBPα ↓, PRDM16 ↑, PGC1α ↑, UCP1 ↑, ERK ↑, (PKA)-mediated browning ↑ | [31] |
3T3-L1 | 3, 6, 12, 25, and 50 µM | C/EBPα ↓, FABP4 ↓, LPAATθ ↓, DGAT1 ↓, SREBP1 ↓, FAS ↓ | [38] | |
Licochalcone A | 3T3-L1 | 5 and 10 µM | PPARγ ↓, C/EBPα ↓, SREBP1c ↓, FAS ↓, SCD1 ↓, GPAT ↓ CPT1 ↑, ACC ↓, AMPK ↑, PPAR-α ↑, UCP1 ↑, | [40] |
- | 35 mg/mL | inhibition of the pancreatic lipase enzyme | [42] | |
Butein | 3T3-L1 | 5, 10, and 25 μM | PPARγ ↓, C/EBPα ↓, Nrf2 ↑, HO-1 ↑ | [46] |
3T3-L1 | 30 µM | HO-1 ↑ | [52] | |
C3H10T1/2 cells | 10 mM | Lipid accumulation ↓, PPARγ ↓, aP2 ↓, and LPL 100% | [53] | |
PPARγ, aP2, and LPL 50% ↓ | ||||
3T3-L1 | 1–40 µM | AMPK ↑, PPARγ ↓, C/EBPα ↓, GPAT-1 ↓, CPT1 ↑, ACC ↑ | [56] | |
Panduratin A | 3T3-L1, HepG2, and L6 skeletal muscle cells | - | Triglyceride accumulation ↓, AMPK ↑, PPARγ ↓, C/EBPα ↓, ACC ↓, FAS ↓, SREBP1c ↓, PPARα ↑, PGC-1α ↑, CPT-1L ↑, CPT-1M ↑, UCPs ↑ | [59] |
Isoliquiritin | Caco-2, HepG2 | 100 μmol/L | Cholesterol lowering, NPC1L1 ↓, HDL catabolism ↑ | [64] |
3T3-L1 | 100 µM | Insulin-stimulated ROS production and adipocyte differentiation ↓, superoxide generation ↓, FABP4 ↓, GLUT4 ↓, PPARγ ↓, C/EBPα ↓, PTP1B oxidation ↓, AKT phosphorylation ↓ | [66] | |
Human adipose-derived stem cells (hASCs) | UCP1 ↑, PRDM16 ↑, JNK ↑ | [69] | ||
Xanthohumol | 3T3-L1 and primary human subcutaneous preadipocytes | CIDE-A ↑, TBX-1 ↑, UCP1 ↑, ACC ↓, HSL ↑, PGC-1α ↑ | [74] | |
Huh-7 | ||||
3T3-L1 | 1.5 mM | [75] | ||
Flavokawains | 3T3-L1 | 10 µg/mL | Adipocyte differentiation ↓, phosphorylation of ERK ↑, lipid accumulation ↓, (C/EBP)-β ↓, C/EBPα ↓, PPARγ ↓ | [77] |
Xanthoangelol | 3T3-L1 | 1, 5, 10, and 30 µM | C/EBP ↓, C/EBP ↓, PPARγ ↓ | [78] |
4-Hydroxyderricin | 3T3-L1 | 1, 5, 10, and 30 µM | Glycerol-3-phosphate acyl transferase-1 ↓, CPT ↑ | [78] |
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Maisto, M.; Marzocchi, A.; Keivani, N.; Piccolo, V.; Summa, V.; Tenore, G.C. Natural Chalcones for the Management of Obesity Disease. Int. J. Mol. Sci. 2023, 24, 15929. https://doi.org/10.3390/ijms242115929
Maisto M, Marzocchi A, Keivani N, Piccolo V, Summa V, Tenore GC. Natural Chalcones for the Management of Obesity Disease. International Journal of Molecular Sciences. 2023; 24(21):15929. https://doi.org/10.3390/ijms242115929
Chicago/Turabian StyleMaisto, Maria, Adua Marzocchi, Niloufar Keivani, Vincenzo Piccolo, Vincenzo Summa, and Gian Carlo Tenore. 2023. "Natural Chalcones for the Management of Obesity Disease" International Journal of Molecular Sciences 24, no. 21: 15929. https://doi.org/10.3390/ijms242115929