New Insights into the Reparative Angiogenesis after Myocardial Infarction
Abstract
:1. Introduction
2. Reparative Role of Mature and Endothelial Progenitor Cells in the Infarcted Heart
3. Signaling Pathways Participating in the Post-Ischemic Angiogenesis
4. Reactive Oxygen Species Regulation of Angiogenesis
5. Ca2+ Signaling in Angiogenesis
6. miRNAs as Regulators of Post-Ischemic Angiogenesis
miRNA | Released or Delivered by | Target Genes | Promotes/ Prevents | References |
---|---|---|---|---|
miR-322/miR-424 | ECs | CUL2/VEGF/GLUT1/EPO/HIF-1α | ↑ | [94] |
miR-19a-3p | Cardiomyocytes | HIF-1α | ↓ | [95] |
miR-126-3p | MSCs/exosomes | PIK3R2/SPRED1/VEGF/bFGF/DLL4/ mTORC1/HIF-1α | ↑ | [97,98] |
EPCs | VEGF-A/IL-10/IL-3/IGF-1/angiogenin | ↑ | [99,115] | |
miR126/miR-130a | MACs | SPRED1 | ↑ | [100] |
miR-130a | Lentivirus | VEGF/HoxA5/AKT | ↑ | [101] |
PTEN | ↓ | |||
miR-375 | LNA anti-miR-375 | PDK-1/AKT | ↓ | [102] |
miR-21-5p | Cardiac stromal cells | PTEN/AKT | ↓/↑ | [103] |
miR-499-5p | Tanshinone IIA administration | PTEN/VEGF/angiotensin-1 | ↑ | [104] |
miR-210 | MSC-EVs; transgenic mice | Efna3/VEGF | ↑ | [118,119] |
miR-378 | CD34+ progenitor cells | SuFu/Fus-1 | ↑ | [105] |
miR-185-5p | ECs | CatK | ↓ | [107] |
miR-143 | Cardiomyocytes | IGF-1R | ↓ | [108] |
miR-92a | ECs | ITGA5 | ↓ | [109] |
miR-24 | encapsuled antagomiR | PAK4, GATA, eNOS | ↓ | [110,111] |
7. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
Abbreviations
References
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Martín-Bórnez, M.; Falcón, D.; Morrugares, R.; Siegfried, G.; Khatib, A.-M.; Rosado, J.A.; Galeano-Otero, I.; Smani, T. New Insights into the Reparative Angiogenesis after Myocardial Infarction. Int. J. Mol. Sci. 2023, 24, 12298. https://doi.org/10.3390/ijms241512298
Martín-Bórnez M, Falcón D, Morrugares R, Siegfried G, Khatib A-M, Rosado JA, Galeano-Otero I, Smani T. New Insights into the Reparative Angiogenesis after Myocardial Infarction. International Journal of Molecular Sciences. 2023; 24(15):12298. https://doi.org/10.3390/ijms241512298
Chicago/Turabian StyleMartín-Bórnez, Marta, Débora Falcón, Rosario Morrugares, Geraldine Siegfried, Abdel-Majid Khatib, Juan A. Rosado, Isabel Galeano-Otero, and Tarik Smani. 2023. "New Insights into the Reparative Angiogenesis after Myocardial Infarction" International Journal of Molecular Sciences 24, no. 15: 12298. https://doi.org/10.3390/ijms241512298