Vista of the Future: Novel Immunotherapy Based on the Human V-Set Immunoregulatory Receptor for Digestive System Tumors
Abstract
:1. Introduction
2. VISTA: An Overview
3. VISTA: Immunological Functions and Their Role in Malignancies
4. Mechanisms of Resistance to Immunotherapy in GI and Their Correlation with VISTA
5. Clinical Trials in GITs
5.1. JNJ-61610588
5.2. CI-8993
5.3. CA-170/AUPM-170
6. Conclusions and Future Perspectives
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
Abbreviations
AE | adverse event |
APC | antigen presenting cell |
CR | complete response |
CTLA-4 | cytotoxic T cell antigen 4 |
ECD | extracellular domain |
GIT | gastrointestinal tumor |
dMMR | mismatch repair deficiency |
MDSC | myeloid-derived suppressor cells |
MSI-H | microsatellite instability |
OS | overall survival |
PD-1/PD-L1 | programmed death receptor 1/programmed cell death ligand 1 |
PR | partial response |
PSGL-1 | P-selectin glycoprotein ligand-1 |
RR | response rate |
RECIST | response evaluation criteria in solid tumors |
SD | stable disease |
TIL | tumor infiltrating lymphocytes |
VISTA | V-domain Ig suppressor of T-cell activation |
VSIG3 | V-set and immunoglobulin domain containing 3 |
VSIR | V-Set Immunoregulatory Receptor |
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Cancer Type | VISTA Expression on Tumor Cells | VISTA Expression on TMEs | Additional Data | Study | Reference |
---|---|---|---|---|---|
Gastric cancer | + | + | VISTA expression is correlated with Lauren type, tumor localization, etc. | Boger et al. | [41] |
Gastric cancer | + | ND | Loss of VISTA expression is a recurrent event correlated with the microenvironment of the tumor. | Wang et al. | [51] |
Hepatocellular carcinoma | + | ND | Dual positive tumors (VISTA +/CD8+) showed better OS. | Zhang et al. | [48] |
Hepatocellular carcinoma | + | ND | Blocking VISTA can suppress tumor growth. | Lei et al. | [8] |
Colorectal carcinoma | + | + | VISTA was mainly expressed on tumor infiltrating leukocytes; expression was higher than PD-L1. | Xie et al. | [28] |
Esophageal adenocarcinoma | + | + | Favorable outcome of VISTA-positive tumors. | Loeser et al. | [52,53] |
Pancreatic ductal adenocarcinoma | ND | + | Higher density of VISTA expression on CD38+ macrophages in contrast to melanoma. | Blando et al. | [49] |
Medication | Target | Population | Status | Phase | NCT |
---|---|---|---|---|---|
JNJ-61610588 | VISTA | Advanced solid tumors progressed after prior treatment. | Terminated | I | NCT02671955 |
CI-8993 | VISTA | Relapse/refractory solid tumors. | Active, not recruiting | I | NCT04475523 |
CA-170 | VISTA PD-L1 | Advanced solid tumors or lymphomas | Completed | I | NCT02812875 |
PD-L2 | Lung cancer, head/neck/oral cavity cancer, MSI-H positive cancers, and Hodgkin lymphoma | Terminated | II | CTRI/2017/12/011026 (India) | |
W0180 | VISTA | Histologically confirmed solid tumors progressed after standard treatment | Recruiting | I | NCT04564417 |
SNS-1 | VISTA | Histologically or cytologically documented locally advanced, unresectable, or metastatic solid tumors. | Recruiting | I/II | NCT05864144 |
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Chmiel, P.; Gęca, K.; Michalski, A.; Kłosińska, M.; Kaczyńska, A.; Polkowski, W.P.; Pelc, Z.; Skórzewska, M. Vista of the Future: Novel Immunotherapy Based on the Human V-Set Immunoregulatory Receptor for Digestive System Tumors. Int. J. Mol. Sci. 2023, 24, 9945. https://doi.org/10.3390/ijms24129945
Chmiel P, Gęca K, Michalski A, Kłosińska M, Kaczyńska A, Polkowski WP, Pelc Z, Skórzewska M. Vista of the Future: Novel Immunotherapy Based on the Human V-Set Immunoregulatory Receptor for Digestive System Tumors. International Journal of Molecular Sciences. 2023; 24(12):9945. https://doi.org/10.3390/ijms24129945
Chicago/Turabian StyleChmiel, Paulina, Katarzyna Gęca, Adam Michalski, Martyna Kłosińska, Agnieszka Kaczyńska, Wojciech P. Polkowski, Zuzanna Pelc, and Magdalena Skórzewska. 2023. "Vista of the Future: Novel Immunotherapy Based on the Human V-Set Immunoregulatory Receptor for Digestive System Tumors" International Journal of Molecular Sciences 24, no. 12: 9945. https://doi.org/10.3390/ijms24129945