Alterations in UPR Signaling by Methylmercury Trigger Neuronal Cell Death in the Mouse Brain
Abstract
:1. Introduction
2. Results
2.1. ERAI-Venus Mice Exhibit Neurological Symptoms Similar to Wild-Type Mice upon MeHg Exposure
2.2. ER Stress Induction by MeHg Exposure in the Cerebral Cortex and Striatum
2.3. The UPR Signals Are Altered by MeHg Exposure in the Mouse Brain
2.4. Alterations of UPR Signaling by MeHg Are Related to Cell Death
3. Discussion
4. Materials and Methods
4.1. Animals
4.2. MeHg Administration
4.3. Hind Limb Extension Analysis
4.4. Measurement of Mercury Deposition
4.5. Immunohistochemistry
4.6. TUNEL Staining
4.7. Statistical Analysis
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Conflicts of Interest
References
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Nomura, R.; Takasugi, N.; Hiraoka, H.; Iijima, Y.; Iwawaki, T.; Kumagai, Y.; Fujimura, M.; Uehara, T. Alterations in UPR Signaling by Methylmercury Trigger Neuronal Cell Death in the Mouse Brain. Int. J. Mol. Sci. 2022, 23, 15412. https://doi.org/10.3390/ijms232315412
Nomura R, Takasugi N, Hiraoka H, Iijima Y, Iwawaki T, Kumagai Y, Fujimura M, Uehara T. Alterations in UPR Signaling by Methylmercury Trigger Neuronal Cell Death in the Mouse Brain. International Journal of Molecular Sciences. 2022; 23(23):15412. https://doi.org/10.3390/ijms232315412
Chicago/Turabian StyleNomura, Ryosuke, Nobumasa Takasugi, Hideki Hiraoka, Yuta Iijima, Takao Iwawaki, Yoshito Kumagai, Masatake Fujimura, and Takashi Uehara. 2022. "Alterations in UPR Signaling by Methylmercury Trigger Neuronal Cell Death in the Mouse Brain" International Journal of Molecular Sciences 23, no. 23: 15412. https://doi.org/10.3390/ijms232315412