Eating the Enemy: Mycoplasma Strategies to Evade Neutrophil Extracellular Traps (NETs) Promoting Bacterial Nucleotides Uptake and Inflammatory Damage
Abstract
:1. Introduction
2. Role of NETs during Bacterial Infection
3. Mycoplasmas and NETs
Species | Nuclease Name | Subcellular Localization | Type of Nuclease | Substrate | Required Divalent Cation | References |
---|---|---|---|---|---|---|
M. agalactiae | MAG_5040 | Membrane-exposed | Endo/Exo | ssDNA, dsDNA, RNA, and plasmid | Mg2+ | [38] |
M. bovis | MnuA | Membrane-exposed | Endo/Exo | dsDNA, plasmid, | Ca2+, Mg2+ | [109] |
MbovNase | Membrane-bound and secreted | Endo | dsDNA, RNA, and plasmid | Ca2+ | [110] | |
M. hominis | MHO_0730 | Membrane-exposed | Endo/Exo | ssDNA, dsDNA, RNA, plasmid | Ca2+ | [34] |
M. pneumoniae | Mpn133 | Membrane-associated | Endo/Exo | ssDNA, dsDNA, RNA, and plasmid | Ca2+ | [111] |
Mpn491 | Secreted | DNAse | DNA | Mg2 | [37] | |
M. genitalium | MG_186 | Membrane-associated | Endo/Exo | ssDNA, dsDNA, RNA, and plasmid | Ca2+ | [112] |
M. hyopneumoniae | Mhp379 | Membrane-exposed | Endo/Exo | ssDNA, dsDNA, RNA, plasmid | Ca2+ | [113] |
Mhp597 | Secreted | Endo/Exo | ssDNA, dsDNA, RNA, and plasmid | Ca2+, Mg2+ | [40] | |
M. gallisepticum | MGA_0676 | Membrane-exposed | Endo/Exo | ssDNA, dsDNA, RNA, and plasmid | Ca2+ | [114] |
M. meleagridis | Mm19 | Membrane-exposed | Endo/Exo | ssDNA, dsDNA, RNA, and plasmid | Mg2 | [115] |
M. pulmonis | MnuA | Membrane | Undefined | DNA | Undefined | [116] |
M. penetrans | P40 | Membrane | Endo/Exo | ssDNA, dsDNA, RNA, and plasmid | Ca2+, Mg2+ | [117,118] |
3.1. Mycoplasma agalactiae
3.2. Mycoplasma bovis
3.3. Mycoplasma hominis
3.4. Mycoplasma pneumoniae
3.5. Mycoplasma hyopneumoniae
4. Relevance of NETs to Immunity and Mycoplasma Acute and Chronic Infections
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Cacciotto, C.; Alberti, A. Eating the Enemy: Mycoplasma Strategies to Evade Neutrophil Extracellular Traps (NETs) Promoting Bacterial Nucleotides Uptake and Inflammatory Damage. Int. J. Mol. Sci. 2022, 23, 15030. https://doi.org/10.3390/ijms232315030
Cacciotto C, Alberti A. Eating the Enemy: Mycoplasma Strategies to Evade Neutrophil Extracellular Traps (NETs) Promoting Bacterial Nucleotides Uptake and Inflammatory Damage. International Journal of Molecular Sciences. 2022; 23(23):15030. https://doi.org/10.3390/ijms232315030
Chicago/Turabian StyleCacciotto, Carla, and Alberto Alberti. 2022. "Eating the Enemy: Mycoplasma Strategies to Evade Neutrophil Extracellular Traps (NETs) Promoting Bacterial Nucleotides Uptake and Inflammatory Damage" International Journal of Molecular Sciences 23, no. 23: 15030. https://doi.org/10.3390/ijms232315030