Near-Infrared Fluorescence Imaging of Renal Cell Carcinoma with ASP5354 in a Mouse Model for Intraoperative Guidance
Abstract
:1. Introduction
2. Materials and Methods
2.1. Animals
2.2. Preparation of Orthotopic Renal Cell Carcinoma Mouse Model
2.3. Materials
2.4. Instruments
2.5. ASP5354 NIRF Imaging
2.6. Histopathological Analysis and NIRF Imaging of Cancerous Kidney Sections
2.7. NIRF Imaging of Cellular Uptake of ASP5354
2.8. ICG NIRF Imaging
2.9. Statistical Analysis
3. Results
3.1. In Vivo NIRF Imaging of ASP5354 Clearance
3.2. In Vivo and Ex Vivo NIRF Imaging of Renal Cell Carcinoma with ASP5354
3.3. NIRF Imaging of Cellar Uptake of ASP5354
3.4. In Vivo NIRF Imaging of Renal Cell Carcinoma with ICG
4. Discussion
5. Conclusions
Funding
Institutional Review Board Statement
Acknowledgments
Conflicts of Interest
References
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Teranishi, K. Near-Infrared Fluorescence Imaging of Renal Cell Carcinoma with ASP5354 in a Mouse Model for Intraoperative Guidance. Int. J. Mol. Sci. 2022, 23, 7228. https://doi.org/10.3390/ijms23137228
Teranishi K. Near-Infrared Fluorescence Imaging of Renal Cell Carcinoma with ASP5354 in a Mouse Model for Intraoperative Guidance. International Journal of Molecular Sciences. 2022; 23(13):7228. https://doi.org/10.3390/ijms23137228
Chicago/Turabian StyleTeranishi, Katsunori. 2022. "Near-Infrared Fluorescence Imaging of Renal Cell Carcinoma with ASP5354 in a Mouse Model for Intraoperative Guidance" International Journal of Molecular Sciences 23, no. 13: 7228. https://doi.org/10.3390/ijms23137228