Alternative Splicing by NOVA Factors: From Gene Expression to Cell Physiology and Pathology
Abstract
:1. Introduction
2. Gene Expression and Alternative Splicing of NOVAs
2.1. Mechanisms of NOVA Gene Expression
2.2. Alternative Splicing of the Two NOVAs
3. Levels and Functions of NOVAs in Neurons and Other Cells
3.1. Neurons
3.2. Neurosecretory Cells
3.3. Non-Neural Cells
3.3.1. Endothelial Cells
3.3.2. Adipocytes
4. Diseases and Therapies
4.1. Neurologic and Non-Neurologic Diseases
4.2. Cancers
4.3. Potential Therapy
5. Conclusions
Funding
Conflicts of Interest
References
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Tissues and Organs | NOVA1 | NOVA2 |
---|---|---|
Subcutaneous adipose | 21 | 7 |
Brain | ||
amigdala | 8 | 10 |
cingulate cortex | 11 | 13 |
caudate | 8 | 10 |
cerebellum | 40 | 15 |
frontal cortex | 20 | 19 |
hippocampus | 9 | 10 |
hypothalamus | 17 | 10 |
accumbens | 9 | 13 |
putamen | 7 | 9 |
spinal cord | 13 | 6 |
substantia nigra | 10 | 6 |
Breast mammary tissue | 17 | 7 |
Cervix | 11 | 5 |
Colon | 9 | 2 |
Kidney | 2 | 3 |
Lung | 1 | 12 |
Pituitary | 12 | 11 |
Thyroid | 3 | 6 |
Uterus | 9 | 6 |
Muscle | 2 | 7 |
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Meldolesi, J. Alternative Splicing by NOVA Factors: From Gene Expression to Cell Physiology and Pathology. Int. J. Mol. Sci. 2020, 21, 3941. https://doi.org/10.3390/ijms21113941
Meldolesi J. Alternative Splicing by NOVA Factors: From Gene Expression to Cell Physiology and Pathology. International Journal of Molecular Sciences. 2020; 21(11):3941. https://doi.org/10.3390/ijms21113941
Chicago/Turabian StyleMeldolesi, Jacopo. 2020. "Alternative Splicing by NOVA Factors: From Gene Expression to Cell Physiology and Pathology" International Journal of Molecular Sciences 21, no. 11: 3941. https://doi.org/10.3390/ijms21113941