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Molecules, Volume 5, Issue 1 (January 2000) – 16 articles , Pages 1-98, Articles M127-M133

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88 KiB  
Review
Recent Developments in the Area of Asymmetric Transfer Hydrogenation
by Martin Wills, Matthew Palmer, Athene Smith, Jennifer Kenny and Tim Walsgrove
Molecules 2000, 5(1), 4-18; https://doi.org/10.3390/50100004 - 21 Jan 2001
Cited by 43 | Viewed by 11843
Abstract
The use of an enantiomerically pure amino alcohol, coupled to a transfer hydrogenation process, in the asymmetric catalysis of the reduction of ketones to alcohols, is described. The process works well for unfunctionalised ketones, affording e.e.s of up to 98%, and excellent conversions. [...] Read more.
The use of an enantiomerically pure amino alcohol, coupled to a transfer hydrogenation process, in the asymmetric catalysis of the reduction of ketones to alcohols, is described. The process works well for unfunctionalised ketones, affording e.e.s of up to 98%, and excellent conversions. We have recently extended, for the first time in this application, the scope of the methodology to the reductions of a-heteroatom substituted substrates, through the use of the appropriate protecting groups on each atom. Full article
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17 KiB  
Editorial
Molecules, MolBank and ECSOC-4
by Reinhard Neier
Molecules 2000, 5(1), 1-3; https://doi.org/10.3390/50100001 - 31 Jan 2000
Cited by 7 | Viewed by 4020
Abstract
It is one of the great ironies of our information age that at the same time that we have the technical capability to make information freely available world-wide, budget problems are seriously endangering the free access to scientific information.[...] Full article
186 KiB  
Article
JChemPaint - Using the Collaborative Forces of the Internet to Develop a Free Editor for 2D Chemical Structures
by Stefan Krause, Egon Willighagen and Christoph Steinbeck
Molecules 2000, 5(1), 93-98; https://doi.org/10.3390/50100093 - 28 Jan 2000
Cited by 76 | Viewed by 12933
Abstract
The open source program for drawing 2D chemical structures JChemPaint, its current features, its envisioned further development and the principles enabling researchers and students at places all over the world to collaboratively develop such a program are described. Full article
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15 KiB  
Article
Substituted Pyrroles
by N. Zh. Mamardashvili, M. E. Kluyeva and O. A. Golubchicov
Molecules 2000, 5(1), 89-92; https://doi.org/10.3390/50100089 - 26 Jan 2000
Cited by 3 | Viewed by 5871
Abstract
A stepwise synthesis of a-unsubstituted pyrroles with desired substituents in the b-positions of the ring has been devised. Full article
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94 KiB  
Short Note
Copper 1,14:7,8-Diethenotetrapyrido-[2,1,6-de:2',1',6'-gh:2'',1'',6'''-na][1,3,5,8,10,12]hexaazacyclotetradecine Trifluoroacetate
by Wen-Jwu Wang, Hai-Yang Liu, Kuo-Shen Chuang and Chi-Fong Luo
Molecules 2000, 5(1), M133; https://doi.org/10.3390/M133 - 24 Jan 2000
Cited by 1 | Viewed by 3682
Abstract
1,14:7,8-Diethenotetrapyrido-[2,1,6-de:2,1,6-gh:2,1,6-na][1,3,5,8,10,12] hexaazacyclotetradecine (H2HAPP) was synthesized according to Ogawas method[1].[...] Full article
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
88 KiB  
Short Note
4-Hydroxy-6-methyl-3-nitroso-1-phenethyl-2(1H)-pyridinone
by Edmont V. Stoyanov and Ivo C. Ivanov
Molecules 2000, 5(1), M132; https://doi.org/10.3390/M132 - 24 Jan 2000
Viewed by 2675
Abstract
The starting 4-hydroxy-6-methyl-1-phenethyl-2(1H)-pyridinone (1) was prepared according to the known procedure [1,2].[...] Full article
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
96 KiB  
Short Note
Methane-diphosphonic Acid Tetraethyl Ester
by Didier Villemin and Frédéric Thibault
Molecules 2000, 5(1), M131; https://doi.org/10.3390/M131 - 24 Jan 2000
Cited by 2 | Viewed by 3101
Abstract
Methanediphosphonic acid tetraethyl ester is a useful intermedaite for the synthesis of phosphonoalkenes [1] or diphosphonoalkenes [2].[...] Full article
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
91 KiB  
Short Note
1-(6-Amino-9H-purin-9-yl)-3-diazoacetone
by Lajos Kovács
Molecules 2000, 5(1), M130; https://doi.org/10.3390/M130 - 24 Jan 2000
Cited by 2 | Viewed by 3402
Abstract
Adenine (1, 0.676 g, 5.0 mmol) was suspended in anhydrous DMF (20 mL) and sodium hydride (55-60 % suspension in mineral oil, 0.262 g, 6.0 mmol) was added at room temperature.[...] Full article
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
87 KiB  
Short Note
N-(3-Trifluoromethylphenyl)-4-nitroaniline
by Edgardo N. Durantini
Molecules 2000, 5(1), M129; https://doi.org/10.3390/M129 - 24 Jan 2000
Viewed by 3030
Abstract
The general part of the experimental section and the purposes of this synthesis have been present elsewhere [1].[...] Full article
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
91 KiB  
Short Note
4-Furyl-6-hydroxy-6-methyl-1,2,4,5,6,7-hexahydro-3H-indazole-3-one
by Elena B. Usova, Ludmila I. Lysenko and Gennady D. Krapivin
Molecules 2000, 5(1), M128; https://doi.org/10.3390/M128 - 24 Jan 2000
Viewed by 3431
Abstract
It is known that indazoles have varied biological activity [1,2].[...] Full article
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
93 KiB  
Short Note
2-Ethoxycarbonyl-3-(2-furyl)-5-hydroxy-5-methylcyclohexanone
by Elena B. Usova, Ludmila I. Lysenko and Gennady D. Krapivin
Molecules 2000, 5(1), M127; https://doi.org/10.3390/M127 - 24 Jan 2000
Viewed by 3242
Abstract
Furylcyclohexanones can be prepared by the reaction of acetoacetic ester (AAE) with b-furyl-a,b-unsaturated ketones [1,2].[...] Full article
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
181 KiB  
Review
A Short Review on Cardiotonic Steroids and Their Aminoguanidine Analogues
by Concepción P. Melero, Manuel Medarde and Arturo San Feliciano
Molecules 2000, 5(1), 51-81; https://doi.org/10.3390/50100051 - 21 Jan 2000
Cited by 103 | Viewed by 15618
Abstract
A short review on cardiotonic steroids and their analogues is presented. The natural, semisynthetic and synthetic derivatives, as well as their mechanism of action and structure-activity relationships are shown, with a special reference to aminoguanidine derivatives. Full article
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86 KiB  
Article
Acid-Base Initiated Cyclization and Retrocyclization Reactions of Ethyl 2-(3-Acylselenoureido)benzoates, -thiophene-3-carboxylates and the Corresponding 2-(3-Acylisoselenoureido) Derivatives
by Jiří Šibor, Dalimil Žůrek, Otakar Humpa and Pavel Pazdera
Molecules 2000, 5(1), 37-50; https://doi.org/10.3390/50100037 - 21 Jan 2000
Cited by 6 | Viewed by 8658
Abstract
Acid and base initiated cyclization and retrocyclization reactions of the selenoureas 1-6 and isoselenoureas 7-12 to fused 4H-1,3-selenazine and 1,2,3,4-tetrahydropyrimidine-4-one skeletons are reported. Fused 2-acylamino-4H-1,3-selenazine-4-ones 13-18 were formed by the action of concentrated sulfuric acid on acylselenoureas 1-6 or on 2,2-dimethylpropanoylisoselenoureas 10-12 at [...] Read more.
Acid and base initiated cyclization and retrocyclization reactions of the selenoureas 1-6 and isoselenoureas 7-12 to fused 4H-1,3-selenazine and 1,2,3,4-tetrahydropyrimidine-4-one skeletons are reported. Fused 2-acylamino-4H-1,3-selenazine-4-ones 13-18 were formed by the action of concentrated sulfuric acid on acylselenoureas 1-6 or on 2,2-dimethylpropanoylisoselenoureas 10-12 at room temperature. On the other hand, benzoylisoselenoureas 7-9 were not obtained in this cyclocondensation under the same conditions. The reaction of potassium ethoxide on selenazines 13-18 in the ethanol solution evoked retrocyclization to the starting acylselenoureas 1-6. Both types of the title compounds, i.e. selenoureas 1-6 and isoselenoureas 7-12, were deprotonated in a methanol solution of potassium hydroxide used in an equimolar amount, giving rise to potassium salts 19-24, which were isolated only for the thiophene series. By heating the separated potassium salts 20, 21, 23 and 24 in the methanol solution provided, deacylation and isoselenoureas 26, 27 were formed. The in situ prepared salts 19, 22 cyclized under the same conditions with deacylation to 4-selanyl-3,4-dihydroquinazoline-4-one 28. The title compounds 1-6, 7-12 and products of their deacylation 26, 27 on boiling in methanolic potassium hydroxide cyclized to the corresponding fused 2-selenoxo-1,2,3,4-tetrahydropyrimidine-4-one potassium salts. These compounds provided pyrimidine-4-ones 28-30 on acidification. Acid initiated retrocyclization 28-30 to the corresponding 2-amino-4H-1,3-selenazine-4-ones was unsuccessful. C, H, N, Se elemental analyses, FTIR, 1H-NMR, and 13C-NMR spectroscopies supported the structure of synthesized compounds.A short review on cardiotonic steroids and their analogues is presented. The natural, semisynthetic and synthetic derivatives, as well as their mechanism of action and structure-activity relationships are shown, with a special reference to aminoguanidine derivatives. Full article
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18 KiB  
Article
On the Need for Multiple Lists of Chemical Information
by Jonathan Goodman
Molecules 2000, 5(1), 33-36; https://doi.org/10.3390/50100033 - 21 Jan 2000
Cited by 2 | Viewed by 6147
Abstract
Cambridge University Department of Chemistry has a list of University Chemistry Departments and Chemistry-related journals around the world: ChemSites (http://www.ch.cam.ac.uk/ChemSitesIndex.html). This article describes what makes it distinct from other lists, and justifies the existence of more than one such list. Full article
65 KiB  
Article
General Method for the Preparation of Substituted 2-Amino-4H,5H-pyrano[4,3-b]pyran-5-ones and 2-Amino-4H-pyrano[3,2-c]pyridine-5-ones
by Edmont V. Stoyanov, Ivo C. Ivanov and Dieter Heber
Molecules 2000, 5(1), 19-32; https://doi.org/10.3390/50100019 - 21 Jan 2000
Cited by 70 | Viewed by 8163
Abstract
Reaction of 4-hydroxy-6-methyl-2-pyrone (1a) as well as 4-hydroxy-6-methyl-2(1H)-pyridones (1b-d) with arylmethylene malononitriles or arylmethylene methyl cyanoacetates (2a-h) leads to the formation of the very stable 5,6-fused bicyclic 2-amino-4Hpyran derivatives 3a-3af. Full article
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37 KiB  
Article
A High-Yielding Synthesis of the Naturally Occurring Antitumour Agent Irisquinone
by John A. Hadfield, Alan T. McGown and John Butler
Molecules 2000, 5(1), 82-88; https://doi.org/10.3390/50100082 - 18 Jan 2000
Cited by 12 | Viewed by 8565
Abstract
A short, high-yielding synthesis of the antitumour agent irisquinone (1) is described. The key steps are the palladium catalysed coupling reaction of dec-9-yn-1-ol with iodide (2) to form alkyne (3) and the Fremy’s salt oxidation of phenol (7). Full article
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