Enhancement of Bottle Gourd Oil Activity via Optimized Self-Dispersing Lipid Formulations (SDLFs) to Mitigate Isoproterenol-Evoked Cardiac Toxicity in Rats via Modulating BNP, MMP2, and miRNA-21 and miRNA-23a Genes’ Expression

Round 1

Reviewer 1 Report

The authors titled “Enhancement of Bottle Gourd Oil Activity via Optimized 2Self-Dispersing Lipid Formulations (SDLFs) to Mitigate 3Isoproterenol-Evoked Cardiac Toxicity in Rats via Modulating 4BMP, MMP2, miRNA-21 and miRNA-23a Genes Expression”, aimed to show that  optimize self-dispersing lipid formulations [SDLFs] of BG oil by applying a full factorial design. They thought that miRNA-21/miRNA-23a could be used as therapeutic targets in the treatment of car- 476diotoxicity in clinical studies. Future in vivo and clinical investigations are required for 477assessment of the therapeutic efficiency of BG oil and its formulations. In terms of the content and quality of the Tables and Figures, the content of this study is sufficient for publication in this journal.

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Author Response

Reviewer 1

Dear Editor,     

On behalf of the authors, we are delighted for considering our work for publishing in Molecules after revision and much thankful for the editor’s and reviewers’ diligent effort in helping to improve our manuscript. In the following document we clarify the inquiries raised during the reviewing cycle and provide our responses for each one raised. The reviewers’ comments were taken into consideration and a detailed clarification is addressed to each reviewers note herein and the corrections were highlighted.

Reviewer 2 Report

The authors have presented an Enhancement of Bottle Gourd Oil Activity via Optimized Self-Dispersing Lipid Formulations (SDLFs) to Mitigate Isoproterenol-Evoked Cardiac Toxicity in Rats via Modulating BMP, MMP2, miRNA-21 and miRNA-23a Genes Expression. it is interesting to read. It is well written and comprehensive that describes the activity at preclinical level. They have attempted to describe the formulation designed. A good number of references have been considered for addressing the whole manuscript. The manuscript is well presented and should be accepted with minor corrections:

1. At some places the spellings are mistaken and needs to be corrected.

2. References may be checked for consistency throughout the manuscript.

Not avialble

Author Response

Reviewer 2

Dear Editor,     

On behalf of the authors, we are delighted for considering our work for publishing in Molecules after revision and much thankful for the editor’s and reviewers’ diligent effort in helping to improve our manuscript. In the following document we clarify the inquiries raised during the reviewing cycle and provide our responses for each one raised. The reviewers’ comments were taken into consideration and a detailed clarification is addressed to each reviewers note herein and the corrections were highlighted.