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New Advances in Non-coding RNAs
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New Advances in Non-coding RNAs

A special issue of Current Issues in Molecular Biology (ISSN 1467-3045). This special issue belongs to the section "Biochemistry, Molecular and Cellular Biology".

Deadline for manuscript submissions: 31 July 2024 | Viewed by 810

Special Issue Editor

Dr. Hiroki Sato

E-Mail Website
Guest Editor
Department of Medicine, Asahikawa Medical University, 2-1 Midorigaoka-Higashi, Asahikawa 078-8510, Hokkaido, Japan
Interests: cancer genomics; carcinogenesis of pancreatic cancer; carcinogenesis of biliary tract cancer; cancer cahexia of hepatobiliary tract and pancreas cancer; cancer-related sarcopenia; hepatobliliary tract cancer related microRNA/non-coding RNA; pancreas cancer related microRNA/non-coding RNA; biomaker of the early detection of cancer; neuroendocrine tumor/carcinoma
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Noncoding RNAs (ncRNAs) constitute an abundant and heterogeneous class of transcripts including microRNAs, long noncoding RNAs, and circular RNAs. They have emerged in the past decade as key players in the regulation of transcriptional programs. Their activity complements transcription factors, either by providing a further level of control of downstream targets or by establishing feedback loops impacting the transcription factor itself. While many examples of the role of ncRNAs have been reported in the literature, we still lack a detailed understanding of the mechanisms underlying their interactions. Classification strategies are thus plagued by frequent mis‑annotations. Contributions to this Special Issue will provide new insights into the identification of ncRNAs, suggest both experimental and computational approaches to clarify their mechanism of action, and describe their activity in the larger context of regulatory networks.

Dr. Hiroki Sato
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Current Issues in Molecular Biology is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • noncoding RNAs (ncRNAs)
  • microRNAs
  • RNA

Published Papers (1 paper)

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Research

16 pages, 4478 KiB  
Article
Correlation between the RNA Expression and the DNA Methylation of Estrogen Receptor Genes in Normal and Malignant Human Tissues
by Ju Rong, Xiaojun Xie, Yongdong Niu and Zhongjing Su
Curr. Issues Mol. Biol. 2024, 46(4), 3610-3625; https://doi.org/10.3390/cimb46040226 - 19 Apr 2024
Viewed by 542
Abstract
Estrogen plays a multifaceted function in humans via interacting with the estrogen receptors ERα, ERβ, and G protein-coupled estrogen receptor 1 (GPER1). Previous research has predominantly concentrated on elucidating the signaling route of estrogen. However, the comprehensive understanding of the expression profile and [...] Read more.
Estrogen plays a multifaceted function in humans via interacting with the estrogen receptors ERα, ERβ, and G protein-coupled estrogen receptor 1 (GPER1). Previous research has predominantly concentrated on elucidating the signaling route of estrogen. However, the comprehensive understanding of the expression profile and control of these estrogen receptors in various human tissues is not well known. In the present study, the RNA levels of estrogen receptors in various normal and malignant human tissues were retrieved from the human protein atlas, the cancer genome atlas (TCGA), and the genotype-tissue expression (GTEx) databases for analyzing the expression profile of estrogen receptors through gene expression profiling interactive analysis (GEPIA). The status of DNA methylation of estrogen receptor genes from TCGA were analyzed through the software Wanderer and cBioPortal. The MethSurv tool was utilized to estimate the relevance between specific cytosine–guanine (CG) methylation and tumor survival. The expression profile analysis revealed that ERα, ERβ, and GPER1 have unique expression patterns in diverse tissues and malignancies. The interesting results were the higher expression of ERβ RNA in the male testis than in females and the positive association between the RNA level of ERα and the androgen receptor in different human normal tissues. Especially, the significant changes in GPER1 expression in multiple malignancies showed a consistent decrease with no exception, which indicates the role of GPER1 in common tumor inhibition. The finding on the expression profile provides clues for exploring novel potential physiological and pathophysiological functions of estrogen. The DNA methylation analysis manifested that the expression of GPER1 and ERα showed a substantial correlation with the methylation of specific CG sites in the cis-regulating region of the gene. However, no such association was observed for ERβ. When comparing tumor tissues to normal tissues, the DNA methylation of certain CG sites of estrogen receptors showed a correlation with tumor survival but did not always correlate with the expression of that gene or with the expression of DNA methyltransferases. We proposed that the variation in DNA methylation at different CG sites in estrogen receptor genes had other functions beyond its regulatory role in its gene expression, and this might be associated with the progression and therapy efficiency of the tumor based on the modulation of the chromatin configuration. Full article
(This article belongs to the Special Issue New Advances in Non-coding RNAs)
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