Production of Microbial Secondary Metabolites from Organic Wastes and Investigation of Their Potential Applications

Topic Information

Dear Colleagues,

The reuse of organic wastes (OWs) for the production of added-value compounds is a topic of great interest, despite concerns related to cost-effective production and the environment. A large amount of OWs is released every year during by-product processing, including agro-crop processing (e.g., agro-residues, wastewater obtained from the wet processing of coffee, cassava, sugar canes, etc.) and fishery by-product processing (e.g., shrimp shells, crab shells, squid pens, and fish heads). These OWs are rich in carbohydrates, proteins, lipids, and minerals. Thus, they may be utilized for various purposes. The aim of this Special Issue is to collect and highlight groundbreaking studies on the production of microbial secondary metabolites from organic wastes, and investigate their potential applications. We welcome studies using OWs to produce bioactive compounds, such as biocontrol and/or plant-prompting agents that have low-cost potential application in agriculture and novel uses in other fields (e.g., medicine, cosmetics, food, etc.).

Prof. Dr. San-Lang Wang
Dr. Van Bon Nguyen
Topic Editors

Keywords

Participating Journals

Journal Name	Impact Factor	CiteScore	Launched Year	First Decision (median)	APC
Agronomy agronomy	3.7	5.2	2011	15.8 Days	CHF 2600
Applied Biosciences applbiosci	-	-	2022	37.7 Days	CHF 1000
Fermentation fermentation	3.7	3.7	2015	14.3 Days	CHF 2600
Fishes fishes	2.3	1.9	2016	15.7 Days	CHF 2600
Foods foods	5.2	5.8	2012	13.1 Days	CHF 2900

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Published Papers (2 papers)

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All Agronomy Applied Biosciences Fermentation Fishes Foods

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27 pages, 788 KiB  

Open AccessReview

Recent Advances in Eco-Friendly and Scaling-Up Bioproduction of Prodigiosin and Its Potential Applications in Agriculture

by Thi Hanh Nguyen, San-Lang Wang and Van Bon Nguyen

Agronomy 2022, 12(12), 3099; https://doi.org/10.3390/agronomy12123099 - 07 Dec 2022

Cited by 9 | Viewed by 2672

Abstract

Prodigiosin is a red pigment produced by various microbial strains, of these, Serratia marcescens has been recorded as the major PG-producing strain. This microbial pigment has attracted much attention because it possesses potential applications in various fields. Thus, this active metabolite has been [...] Read more.

Prodigiosin is a red pigment produced by various microbial strains, of these, Serratia marcescens has been recorded as the major PG-producing strain. This microbial pigment has attracted much attention because it possesses potential applications in various fields. Thus, this active metabolite has been increasingly studied for bioproduction and investigated for its novel applications. Recently, several prodigiosin-related reviews were reported. These studies covered some aspects of the general physicochemical properties, pathway synthesis, production, and applications of prodigiosin in medicine. However, only a few works discussed the eco-friendly production of prodigiosin from organic wastes. Remarkably, the scaling-up of prodigiosin production and its potential applications in agriculture have rarely been reviewed or discussed. This review extensively presents and discusses the green biosynthesis, enhancement, and scaling-up of prodigiosin production from a wide range of organic byproducts/wastes using different methods of fermentation. Notably, this paper highlights the novel and promising applications of prodigiosin in agriculture via in vitro tests, greenhouse tests, and field studies. The action mechanisms related to some potential bioactivities and the toxicology studies of prodigiosin are also discussed. This review thus supplies scientific data for further research and the application of prodigiosin in the future. Full article

(This article belongs to the Topic Production of Microbial Secondary Metabolites from Organic Wastes and Investigation of Their Potential Applications)

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14 pages, 4257 KiB  

Open AccessArticle

Novel Nematocidal Compounds from Shrimp Shell Wastes Valorized by Bacillus velezensis RB.EK7 against Black Pepper Nematodes

by Thi Huyen Trang Trinh, San-Lang Wang, Van Bon Nguyen, Tu Quy Phan, Manh Dung Doan, Thi Phuong Hanh Tran, Thi Huyen Nguyen, Thi Anh Hong Le, That Quang Ton and Anh Dzung Nguyen

Agronomy 2022, 12(10), 2300; https://doi.org/10.3390/agronomy12102300 - 25 Sep 2022

Cited by 5 | Viewed by 1828

Abstract

Among various organic wastes, shrimp shell powder (SSP) was the most suitable carbon/nitrogen source for producing antinematode compounds (ANCs) via Bacillus veleznesis RB.EK7 fermentation. The fermentation process for the enhancement of antinematode activity was investigated. B. veleznesis RB.EK7 produced the highest antinematode activity [...] Read more.

Among various organic wastes, shrimp shell powder (SSP) was the most suitable carbon/nitrogen source for producing antinematode compounds (ANCs) via Bacillus veleznesis RB.EK7 fermentation. The fermentation process for the enhancement of antinematode activity was investigated. B. veleznesis RB.EK7 produced the highest antinematode activity in the medium containing 0.8% SSP with an initial pH of 6.5–7.0, and fermentation was performed at 35–37 °C with a saking speed of 150 rpm for 72 h. Targeting ANCs were purified from the fermented culture broth and identified as thymine (1) and hexahydropyrrolo [1,2-a]pyrazine-1,4-dione (2) based on nuclear magnetic resonance (NMR) and mass spectra analysis and were compared to those of the reported compounds. Notably, for the first time, these compounds were found as novel ANCs. Thymine (1) demonstrated a potential nematicidal effect with near 100% mortality of second-stage juvenile (J2) nematodes and anti-egg hatching effects of 70.1%, while hexahydropyrrolo [1,2-a]pyrazine-1,4-dione showed moderate antinematode activities with 64.2% mortality of J2 nematodes and anti-egg hatching effects of 57.9%. The docking study coupled with experimental enzyme inhibition results indicated that the potent nematicidal effect of these compounds may be possibly due to the inhibition of the targeting enzyme acetylcholinesterase. The data of this study suggest that SSP can be potentially reused for the eco-friendly production of ANCs for the management of black pepper nematodes. Full article

(This article belongs to the Topic Production of Microbial Secondary Metabolites from Organic Wastes and Investigation of Their Potential Applications)

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