2. Mesosystem Investigação & Investimentos by Spinpark, Barco, 4805-017 Guimarães, Portugal
New Challenges in Ocular Drug Delivery
The clinical treatment of diseases affecting the eye globe, and specifically the retina and posterior eye segment, is often hindered by the physiological protection structures and mechanisms of the organ, as well as by the unsuitable physico-chemical features of the active molecules. Intravitreal injections of drugs and monoclonal antibodies is at present the most common therapeutic procedure to reach the retinal area, however being associated to a high risk of side effects, apart than requiring the intervention of a physician. One of the ‘dream goals’ in this field still remains reaching the retinal area using a simple topically applied eye-drop formulation. Researches in the last years have progressively made available new strategies and technologies to overcome the problems that hinder an efficacious ocular drug bioavailability, leading to even more safe, easy-to-use and highly compliant therapeutic means. Controlled release as well as nanomedicine approaches, mainly based on polymeric or lipid matrices, are among the most largely explored strategies to pursue this aim. The Topic is aimed at collecting the most recent experiences from worldwide laboratories to make an update of the state-of-the-art and open new perspectives toward innovative and effective ocular therapies. In particular, studies dealing with biotech products and gene material will be welcommed, since the association of new therapeutic means with personalized treatments is ready to become the most exciting ambition for the next future of ophthalmology.
Prof. Dr. Rosario Pignatello
Dr. Hugo Almeida
Dr. Debora Santonocito
Dr. Carmelo Puglia
- ocular diseases
- drug delivery
- drug targeting
- controlled drug release
- ophthalmic formulations
- eye drops
|Journal Name||Impact Factor||CiteScore||Launched Year||First Decision (median)||APC|
Journal of Nanotheranosticsjnt
|-||-||2020||15.0 days *||1000 CHF||Submit|
|5.719||6.6||2011||12.7 Days||2600 CHF||Submit|
|5.215||4.0||2004||15.6 Days||2200 CHF||Submit|
|6.525||6.0||2009||15.9 Days||2600 CHF||Submit|
Journal of Functional Biomaterialsjfb
|4.901||10.0||2010||11.9 Days||2000 CHF||Submit|
* Median value for all MDPI journals in the second half of 2022.
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