Topic Editors

LAQV-REQUIMTE, Department of Chemistry, Universidade de Aveiro, 3810-193 Aveiro, Portugal
LAQV-REQUIMTE, Department of Chemistry, Universidade de Aveiro, 3810-193 Aveiro, Portugal
MARE - Marine and Environmental Sciences Centre, School of Tourism and Maritime Technology, Polytechnic of Leiria, Leiria, Portugal

Marine Natural Compounds – from Chemistry to Application

Abstract submission deadline
closed (30 January 2023)
Manuscript submission deadline
closed (30 April 2023)
Viewed by
6625

Topic Information

Dear Colleagues,

The oceans are a place of incredible biodiversity, and marine life represents almost 80% of the world's biota. Thus, not surprisingly, marine organisms such as tunicates, mollusks, sponges, sea slugs, bryozoans, bacteria, cyanobacteria, algae, specific fish species, and crustaceans are an inexhaustible source of chemical entities with proven bioactivities, including antimicrobial, antifibrotic, analgesic, anti-inflammatory, antitumor, cancer preventive, neuroprotective, and others. In fact, marine organisms represent the most recent source of bioactive natural products concerning terrestrial plants, with over 99% considered new compounds, with no analogues found among terrestrial organisms. Thus, even far from traditional medicine applications, widely applied to terrestrial plants, marine organisms have asserted themselves in several domains, such as medicinal, pharmaceutical, nutraceutical, and agriculture, with considerable bioeconomic benefits for different industries. Notably, there are presently several approved drugs and more than 20 other compounds in different clinical phases, mainly of marine invertebrate and microorganism origin. Many molecules with biomedical functions from marine sources are also used as pharmaceuticals, while marine products represent a large portion of the global nutraceutical market. This transdisciplinary Topic aims to bring together original research and review articles covering distinct aspects related to marine natural products, including but not limited to their extraction and purification; structural characterization of new compounds; biological activities and mechanisms of actions of extracts, purified fractions, isolated compounds, and/or of novel value-added products; structure-bioactive relations; interaction with other substances in the formulated matrices; and safety and stability of new value-added products.

Dr. Susana M. Cardoso
Dr. Diana Cláudia Pinto
Dr. Maria Manuel Gil
Topic Editors

Keywords

  • primary and secondary metabolites
  • bioactive properties
  • blue bioeconomy
  • technological applications
  • isolation of bioactive compounds
  • value-added products

Participating Journals

Journal Name Impact Factor CiteScore Launched Year First Decision (median) APC
Chemistry
chemistry
2.1 2.5 2019 19.1 Days CHF 1800
International Journal of Molecular Sciences
ijms
5.6 7.8 2000 16.3 Days CHF 2900
Marine Drugs
marinedrugs
5.4 9.6 2003 14 Days CHF 2900
Methods and Protocols
mps
2.4 3.8 2018 27.9 Days CHF 1800
Molecules
molecules
4.6 6.7 1996 14.6 Days CHF 2700
Sustainability
sustainability
3.9 5.8 2009 18.8 Days CHF 2400

Preprints.org is a multidiscipline platform providing preprint service that is dedicated to sharing your research from the start and empowering your research journey.

MDPI Topics is cooperating with Preprints.org and has built a direct connection between MDPI journals and Preprints.org. Authors are encouraged to enjoy the benefits by posting a preprint at Preprints.org prior to publication:

  1. Immediately share your ideas ahead of publication and establish your research priority;
  2. Protect your idea from being stolen with this time-stamped preprint article;
  3. Enhance the exposure and impact of your research;
  4. Receive feedback from your peers in advance;
  5. Have it indexed in Web of Science (Preprint Citation Index), Google Scholar, Crossref, SHARE, PrePubMed, Scilit and Europe PMC.

Published Papers (3 papers)

Order results
Result details
Journals
Select all
Export citation of selected articles as:
26 pages, 7845 KiB  
Article
Multiomic Approach for Bioprospection: Investigation of Toxins and Peptides of Brazilian Sea Anemone Bunodosoma caissarum
by Maria Eduarda Mazzi Esquinca, Claudia Neves Correa, Gabriel Marques de Barros, Horácio Montenegro and Leandro Mantovani de Castro
Mar. Drugs 2023, 21(3), 197; https://doi.org/10.3390/md21030197 - 22 Mar 2023
Cited by 5 | Viewed by 2134
Abstract
Sea anemones are sessile invertebrates of the phylum Cnidaria and their survival and evolutive success are highly related to the ability to produce and quickly inoculate venom, with the presence of potent toxins. In this study, a multi-omics approach was applied to characterize [...] Read more.
Sea anemones are sessile invertebrates of the phylum Cnidaria and their survival and evolutive success are highly related to the ability to produce and quickly inoculate venom, with the presence of potent toxins. In this study, a multi-omics approach was applied to characterize the protein composition of the tentacles and mucus of Bunodosoma caissarum, a species of sea anemone from the Brazilian coast. The tentacles transcriptome resulted in 23,444 annotated genes, of which 1% showed similarity with toxins or proteins related to toxin activity. In the proteome analysis, 430 polypeptides were consistently identified: 316 of them were more abundant in the tentacles while 114 were enriched in the mucus. Tentacle proteins were mostly enzymes, followed by DNA- and RNA-associated proteins, while in the mucus most proteins were toxins. In addition, peptidomics allowed the identification of large and small fragments of mature toxins, neuropeptides, and intracellular peptides. In conclusion, integrated omics identified previously unknown or uncharacterized genes in addition to 23 toxin-like proteins of therapeutic potential, improving the understanding of tentacle and mucus composition of sea anemones. Full article
Show Figures

Graphical abstract

19 pages, 3956 KiB  
Article
Preparation and Hepatoprotective Activities of Peptides Derived from Mussels (Mytilus edulis) and Clams (Ruditapes philippinarum)
by Qian Wang, Fu-Jun Liu, Xin-Miao Wang, Guan-Hua Zhao, Dong Cai, Jing-Han Yu, Fa-Wen Yin and Da-Yong Zhou
Mar. Drugs 2022, 20(11), 719; https://doi.org/10.3390/md20110719 - 16 Nov 2022
Cited by 6 | Viewed by 1494
Abstract
Low molecular weight (<5 kDa) peptides from mussels (Mytilus edulis) (MPs) and the peptides from clams (Ruditapes philippinarum) (CPs) were prepared through enzymatic hydrolysis by proteases (dispase, pepsin, trypsin, alcalase and papain). Both the MPs and the CPs showed [...] Read more.
Low molecular weight (<5 kDa) peptides from mussels (Mytilus edulis) (MPs) and the peptides from clams (Ruditapes philippinarum) (CPs) were prepared through enzymatic hydrolysis by proteases (dispase, pepsin, trypsin, alcalase and papain). Both the MPs and the CPs showed excellent in vitro scavenging ability of free radicals including OH, DPPH and ABTS in the concentration range of 0.625–10.000 mg/mL. By contrast, the MPs hydrolyzed by alcalase (MPs-A) and the CPs hydrolyzed by dispase (CPs-D) had the highest antioxidant activities. Furthermore, MPs-A and CPs-D exhibited protective capabilities against oxidative damage induced by H2O2 in HepG2 cells in the concentration range of 25–800 μg/mL. Meanwhile, compared with the corresponding indicators of the negative control (alcohol-fed) mice, lower contents of hepatic MDA and serums ALT and AST, as well as higher activities of hepatic SOD and GSH-PX were observed in experiment mice treated with MPs-A and CPs-D. The present results clearly indicated that Mytilus edulis and Ruditapes philippinarum are good sources of hepatoprotective peptides. Full article
Show Figures

Figure 1

11 pages, 1846 KiB  
Article
Paspalines C–D and Paxillines B–D: New Indole Diterpenoids from Penicillium brefeldianum WZW-F-69
by Weiwen Lin, Hanpeng Li, Zhiwen Wu, Jingyi Su, Zehong Zhang, Li Yang, Xianming Deng and Qingyan Xu
Mar. Drugs 2022, 20(11), 684; https://doi.org/10.3390/md20110684 - 29 Oct 2022
Cited by 4 | Viewed by 1671
Abstract
Five new indole diterpenoids named paspaline C–D (12) and paxilline B–D (35), as well as eleven known analogues (616), were identified from fungus Penicillium brefeldianum strain WZW-F-69, which was isolated from [...] Read more.
Five new indole diterpenoids named paspaline C–D (12) and paxilline B–D (35), as well as eleven known analogues (616), were identified from fungus Penicillium brefeldianum strain WZW-F-69, which was isolated from an abalone aquaculture base in Fujian province, China. Their structures were elucidated mainly through 1D- and 2D-NMR spectra analysis and ECD comparison. Compound 1 has a 6/5/5/6/6/8 hexacyclic ring system bearing 2,2-dimethyl-1,3-dioxocane, which is rare in natural products. Compound 2 has an unusual open F-ring structure. The cytotoxic activities against 10 cancer cell lines and antimicrobial activities against model bacteria and fungi of all compounds were assayed. No compound showed antimicrobial activity, but at a concentration of 1 μM, compounds 1 and 6 exhibited the highest inhibition rates of 71.2% and 83.4% against JeKo-1 cells and U2OS cells, respectively. Full article
Show Figures

Graphical abstract

Back to TopTop