Dynamic Nano-Biomaterials in Tissue Remodeling and Drug Delivery

Topic Information

Dear Colleagues,

In recent years, trends in dynamic nanomaterials' response to cell engineering have led to novel tissue remodeling approaches to understanding cell regulatory mechanisms and related applications better. Specifically, the combination of novel biomaterials-associated systems and techniques in regenerative tissue approaches allows us to monitor the cellular response during materials applications. Moreover, the tissue-specific micro-environment surrounding cells is a dynamic rather than static condition. Taking advantage of various biomaterials and cell-specific modulatory functions, we aimed to focus this Topic on the use of dynamic nanomaterials in tissue remodeling and drug delivery functions for various biomedical applications. Ultimately, our approach invites papers in biomaterials modulation of cell fate decision/drug delivery using dynamically engineered biomaterials, giving a novel conceptual approach to regenerative medicine, stem cell therapy, immune modulation, and cancer therapies. Our vision is to provide a suitable platform for novel biological insights into biomaterials’ role in cell engineering, cell–materials interactions, extracellular matrix modulation, stem cell biology, novel drug delivery, stimuli-responsive drug delivery, and cancer-targeted delivery therapies. This Topic will also present the importance of advanced nanomaterials and functional materials platforms for cell, nano-, healthcare, and materials technologists who are looking to publish papers related to nanoengineering attributes. Finally, the Topic will examine the emerging aspects of dynamic biomaterials and their advanced applications, focusing on tissue engineering and drug delivery for their outlook.

Dr. Ramar Thangam
Dr. Heemin Kang
Dr. Bibin G. Anand
Dr. Ramachandran Vijayan
Topic Editors

Keywords

Participating Journals

Journal Name	Impact Factor	CiteScore	Launched Year	First Decision (median)	APC
Bioengineering bioengineering	4.6	4.2	2014	15.6 Days	CHF 2700
Biomolecules biomolecules	5.5	8.3	2011	19.2 Days	CHF 2700
International Journal of Molecular Sciences ijms	5.6	7.8	2000	16.8 Days	CHF 2900
Nanomaterials nanomaterials	5.3	7.4	2011	11.7 Days	CHF 2900

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All Bioengineering Biomolecules IJMS Nanomaterials

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Open AccessArticle

Sirolimus-Embedded Silk Microneedle Wrap to Prevent Neointimal Hyperplasia in Vein Graft Model

by

Jung-Hwan Kim

,

Eui Hwa Jang

,

Ji-Yeon Ryu

,

Jiyong Lee

,

Jae Ho Kim

,

Wonhyoung Ryu

and

Young-Nam Youn

Int. J. Mol. Sci. 2023, 24(4), 3306; https://doi.org/10.3390/ijms24043306 - 07 Feb 2023

Viewed by 1090

Abstract

We investigated the role of a sirolimus-embedded silk microneedle (MN) wrap as an external vascular device for drug delivery efficacy, inhibition of neointimal hyperplasia, and vascular remodeling. Using dogs, a vein graft model was developed to interpose the carotid or femoral artery with [...] Read more.

We investigated the role of a sirolimus-embedded silk microneedle (MN) wrap as an external vascular device for drug delivery efficacy, inhibition of neointimal hyperplasia, and vascular remodeling. Using dogs, a vein graft model was developed to interpose the carotid or femoral artery with the jugular or femoral vein. The control group contained four dogs with only interposed grafts; the intervention group contained four dogs with vein grafts in which sirolimus-embedded silk-MN wraps were applied. After 12-weeks post-implantation, 15 vein grafts in each group were explanted and analyzed. Vein grafts applied with the rhodamine B–embedded silk-MN wrap showed far higher fluorescent signals than those without the wrap. The diameter of vein grafts in the intervention group decreased or remained stable without dilatation; however, it increased in the control group. The intervention group had femoral vein grafts with a significantly lower mean neointima-to-media ratio, and had vein grafts with an intima layer showing a significantly lower collagen density ratio than the control group. In conclusion, sirolimus-embedded silk-MN wrap in a vein graft model successfully delivered the drug to the intimal layer of the vein grafts. It prevented vein graft dilatation, avoiding shear stress and decreasing wall tension, and it inhibited neointimal hyperplasia. Full article

(This article belongs to the Topic Dynamic Nano-Biomaterials in Tissue Remodeling and Drug Delivery)

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