Topic Editors

Department of Neurosurgery, University Hospital Bonn, Venusberg-Campus 1, 53127 Bonn, Germany
Department of Neurosurgery, University Hospital Leipzig, 04103 Leipzig, Germany
Dr. Martin Vychopen
Department of Neurosurgery, University Hospital Bonn, 53127 Bonn, Germany

Inflammation in Neuro-Oncological Diseases and in Neuro-Vascular Diseases

Abstract submission deadline
closed (31 December 2023)
Manuscript submission deadline
closed (31 March 2024)
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6993

Topic Information

Dear Colleagues,

Neuroinflammation plays an essential role in tumorigenesis, malignant progression, vascular inflammation, and clinical symptomatology. The central nervous system (CNS) microenvironment has a significant role in those pathophysiological processes. Interleukins, immune infiltrates, cyclooxygenases, etc. are important drivers in those diseases. On a cellular basis, tumor-associated macrophages, reactive astrocytes, leukocytes, platelets, and further contributors of the inflammatory response influence diseases’ progression and response to treatment. Several preclinical and clinical trials investigating neuroinflammation and pharmacological modulation of the immune system have improved our understanding of the immune response in neuro-oncological and neurovascular diseases. This Topic Issue will focus on preclinical and clinical data regarding the interaction between neuro-oncological or neurovascular diseases and neuroinflammation.

Prof. Dr. Erdem Güresir
Dr. Johannes Wach
Dr. Martin Vychopen
Topic Editors

Keywords

  • inflammation
  • neuro-oncology
  • brain tumors
  • interleukins
  • neurovascular
  • subarachnoid hemorrhage
  • macrophages
  • immune microenvironment
  • inflammatory pathways

Participating Journals

Journal Name Impact Factor CiteScore Launched Year First Decision (median) APC
Brain Sciences
brainsci
3.3 3.9 2011 15.6 Days CHF 2200
Cancers
cancers
5.2 7.4 2009 17.9 Days CHF 2900
Journal of Clinical Medicine
jcm
3.9 5.4 2012 17.9 Days CHF 2600
Journal of Vascular Diseases
jvd
- - 2022 25 Days CHF 1000
Neurology International
neurolint
3.0 2.2 2009 23.3 Days CHF 1600

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Published Papers (4 papers)

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9 pages, 443 KiB  
Review
Congenital Optic Disc Anomalies: Insights from Multimodal Imaging
by Gilda Cennamo, Michele Rinaldi, Marina Concilio and Ciro Costagliola
J. Clin. Med. 2024, 13(5), 1509; https://doi.org/10.3390/jcm13051509 - 06 Mar 2024
Viewed by 550
Abstract
In this comprehensive review, we delve into the significance of multimodal imaging in diagnosing and managing complications of congenital optic disc anomalies. While the fundus examination is the gold standard tool in the diagnosis of these pathologies, spectral domain (SD) optical coherence tomography [...] Read more.
In this comprehensive review, we delve into the significance of multimodal imaging in diagnosing and managing complications of congenital optic disc anomalies. While the fundus examination is the gold standard tool in the diagnosis of these pathologies, spectral domain (SD) optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA) could shed light on the pathogenesis and treatment. Moreover, this review seeks to offer a comprehensive insight into the multimodal approach of these rare congenital pathologies. In conclusion, congenital anomalies of the optic nerve represent a major challenge for ophthalmologists. Further research could be useful to clarify the pathophysiology of these diseases and define a correct and more specific treatment approach. Full article
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13 pages, 266 KiB  
Article
Neutrophil–Lymphocyte Ratio as a Predictor of Cerebral Small Vessel Disease in a Geriatric Community: The I-Lan Longitudinal Aging Study
by Shao-Yuan Chuang, Yin-Chen Hsu, Kuang-Wei Chou, Kuo-Song Chang, Chiong-Hee Wong, Ya-Hui Hsu, Hao-Min Cheng, Chien-Wei Chen and Pang-Yen Chen
Brain Sci. 2023, 13(7), 1087; https://doi.org/10.3390/brainsci13071087 - 18 Jul 2023
Cited by 3 | Viewed by 2037
Abstract
Cerebral Small Vessel Disease (CSVD) frequently affects the elderly, with inflammation playing a crucial role in related health complications, including dementia, stroke, and SVD. Studies, including animal experiments, indicate a strong link between inflammation and SVD progression. The Neutrophil-Lymphocyte Ratio (NLR) serves as [...] Read more.
Cerebral Small Vessel Disease (CSVD) frequently affects the elderly, with inflammation playing a crucial role in related health complications, including dementia, stroke, and SVD. Studies, including animal experiments, indicate a strong link between inflammation and SVD progression. The Neutrophil-Lymphocyte Ratio (NLR) serves as a possible biomarker for ongoing inflammatory risks. A total of 720 adults aged 50 years or older from the community-based I-Lan Longitudinal Aging Study were included in this study. General linear regression and ordinally logistic regression analyses were performed to evaluate the association between NLR and CSVD. We further examined the presence of lacune, microbleed, and white matter hyperintensity (WMH) on brain MRI, which were used to construct a combined CSVD score. The NLR was positively associated with WMH (adjusted r = 0.109, p = 0.003), microbleed (adjusted r = 0.102, p = 0.006), and lacune (adjusted r = 0.100, p = 0.008). After adjustments for smoking, drinking, and physical activity in the ordinal logistic regression analysis, age, gender, brachial Systolic Blood Pressure (SBP), fasting glucose, LDL-cholesterol, and Hs-CRP were compared among subjects with low tertile (T1), medium tertile (T2) and high tertile (T3) NLR. The results showed that T2 vs. T1 had an odds ratio of 1.23 (0.86–1.77); and T3 vs. T1 had an odds ratio of 1.87 (1.29–2.71) of CSVD scores in four groups (zero (reference group), one, two, and three or more). NLR could be used to assess the state of inflammation in cerebral vessels. A significant and positive correlation between NLR and CSVD was verified in this study. However, the practical clinical application of NLR in CSVD patients and prognosis prediction should be validated through more scientific attempts. Full article
15 pages, 2135 KiB  
Article
Prognostic Value of Systemic Immune-Inflammation Index (SII) in Patients with Glioblastoma: A Comprehensive Study Based on Meta-Analysis and Retrospective Single-Center Analysis
by Chao Yang, Bo-Wen Hu, Feng Tang, Qing Zhang, Wei Quan, Jie Wang, Ze-Fen Wang, Yi-Rong Li and Zhi-Qiang Li
J. Clin. Med. 2022, 11(24), 7514; https://doi.org/10.3390/jcm11247514 - 19 Dec 2022
Cited by 7 | Viewed by 1705
Abstract
Inflammation is related to cancer. The systemic immune-inflammation index (SII) has been linked to the prognosis of many types of cancer. The present study aimed to determine the prognostic value of the SII in glioblastoma (GBM) patients based on meta-analysis and single-center retrospective [...] Read more.
Inflammation is related to cancer. The systemic immune-inflammation index (SII) has been linked to the prognosis of many types of cancer. The present study aimed to determine the prognostic value of the SII in glioblastoma (GBM) patients based on meta-analysis and single-center retrospective analysis. Relevant publications published before 1 October 2022 were identified by searching PubMed, EMBASE, Cochrane Library databases, and Web of Science. Moreover, 208 GBM patients from Zhongnan Hospital were incorporated. Kaplan–Meier and Cox regression analyses determined the prognostic significance of inflammatory markers. By combining these indicators, we developed scoring systems. Nomograms were also built by incorporating independent variables. The accuracies of nomograms were evaluated by Harrell’s concordance index (c-index) and the calibration curve. According to meta-analysis, an elevated SII predicted the worst overall survival (OS) (Hazard ratio [HR] = 1.87, p < 0.001). Furthermore, a higher SII (>510.8) (HR = 1.782, p = 0.007) also predicted a poorer outcome in a retrospective cohort. The scoring systems of SII-NLR (neutrophil-to-lymphocyte ratio) showed the best predictive power for OS. The nomogram without MGMT (c-index = 0.843) exhibited a similar accuracy to that with MGMT (c-index = 0.848). A pre-treatment SII is independently associated with OS in GBM. A nomogram integrating the SII-NLR score may facilitate a comprehensive survival evaluation independent of molecular tests in GBM. Full article
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12 pages, 1489 KiB  
Article
The Effect of Losartan on Neuroinflammation as Well as on Endothelin-1- and Serotonin-Induced Vasoconstriction in a Double-Haemorrhage Rat Model
by Jürgen Konczalla, Jan Mrosek, Sepide Kashefiolasl, Christian Musahl, Serge Marbacher, Gerrit Alexander Schubert, Lukas Andereggen and Stefan Wanderer
J. Clin. Med. 2022, 11(24), 7367; https://doi.org/10.3390/jcm11247367 - 12 Dec 2022
Viewed by 1033
Abstract
Poor patient outcome after aneurysmal subarachnoid haemorrhage (SAH) is due to a multifactorial process. Delayed cerebral vasospasm, ischemic neurological deficits, and infarction are the most feared acute sequelae triggered by enhanced synthesis of serotonin and endothelin-1 (ET-1). During the past decades, multiple drugs [...] Read more.
Poor patient outcome after aneurysmal subarachnoid haemorrhage (SAH) is due to a multifactorial process. Delayed cerebral vasospasm, ischemic neurological deficits, and infarction are the most feared acute sequelae triggered by enhanced synthesis of serotonin and endothelin-1 (ET-1). During the past decades, multiple drugs have been analysed for protective effects without resounding success. Therefore, the authors wanted to analyse the potential beneficial role of Losartan (LOS). Male Sprague Dawley rats were randomised into either a group receiving two injections of blood into the cisterna magna (SAH group) or a group receiving two injections of isotonic sodium chloride (sham group). The animals were culled on day five and basilar artery ring segments were used for in vitro tension studies. Sarafotoxin S6c caused a dose-dependent vasorelaxation in sham and SAH segments, which was more pronounced in sham segments. LOS, applied in a concentration of 10−3 M, was able to significantly reduce serotonin- (p < 0.01) and ET-1- (p < 0.05, p < 0.01) mediated vasoconstriction in sham segments. These findings, along with the well-known beneficial effects of LOS on restoring the impaired endothelin-B1-receptor function after SAH, as well as on the neuroprotectional and antiepileptogenic aspects, might be implemented in advancing tailored concepts to sufficiently ameliorate patients’ functional outcome after SAH. Full article
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