Advances in Astrobiology

Abstract submission deadline

30 June 2024

Manuscript submission deadline

30 November 2024

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Topic Information

Dear Colleagues,

Astrobiology is defined as the study of the origin, evolution, distribution, and future of life in the universe. This Topic seeks to collect papers that aim to answer some fundamental questions about the beginning and evolution of life on Earth (including the geological records of biosphere evolutions), possible existence of extraterrestrial life, and the future of life on Earth and other moons and planets. This Special Issue is particularly addressed to those scientists that study the emergence of life on Earth, determine how early life on Earth interacted and evolved with its changing environment, understand the evolutionary mechanisms and environmental limits of life, and explore habitable environments in our solar system and search for life, as well as those scientists that contribute to understanding the nature and distribution of habitable environments in the universe. We also seek papers aimed at recognizing signatures of life on early Earth and on other worlds, studying the nonbiological origin of organic compounds and the boundaries of habitable zones, bioregenerative life support systems, and the environmental limits of life. Finally, we seek papers focusing on the challenges posed by human presence in both low Earth orbit (e.g., ISS) and extraterrestrial orbiting stations (e.g., the Moon Space Gateway) or planetary bases, and the effect of space-related factors, such as altered gravity and magnetic fields, radiation, confinement, altered circadian rhythms, limited social interactions, high labor charge, psychological pressure, and limited or no access to fresh food.

Prof. Dr. Massimo Maffei
Dr. Barbara Cavalazzi
Dr. Marta del Bianco
Topic Editors

Keywords

Participating Journals

Journal Name	Impact Factor	CiteScore	Launched Year	First Decision (median)	APC
International Journal of Molecular Sciences ijms	5.6	7.8	2000	16.8 Days	CHF 2900	Submit
Pharmaceutics pharmaceutics	5.4	6.9	2009	17 Days	CHF 2900	Submit
Cells cells	6.0	9.0	2012	18.8 Days	CHF 2700	Submit
Biomolecules biomolecules	5.5	8.3	2011	19.2 Days	CHF 2700	Submit
Plants plants	4.5	5.4	2012	15.3 Days	CHF 2700	Submit
Universe universe	2.9	3.6	2015	17.6 Days	CHF 2400	Submit
Cancers cancers	5.2	7.4	2009	18.2 Days	CHF 2900	Submit
Antioxidants antioxidants	7.0	8.8	2012	14.4 Days	CHF 2900	Submit

Published Papers (1 paper)

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All IJMS Pharmaceutics Cells Biomolecules Plants Universe Cancers Antioxidants

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Open AccessArticle

YAP Inhibition Alleviates Simulated Microgravity-Induced Mesenchymal Stem Cell Senescence via Targeting Mitochondrial Dysfunction

by

Wenjun Lv

,

Xiufen Peng

,

Yun Tu

,

Yisong Shi

,

Guanbin Song

and

Qing Luo

Antioxidants 2023, 12(5), 990; https://doi.org/10.3390/antiox12050990 - 24 Apr 2023

Viewed by 1112

Abstract

Weightlessness in space leads to bone loss, muscle atrophy, and impaired immune defense in astronauts. Mesenchymal stem cells (MSCs) play crucial roles in maintaining the homeostasis and function of the tissue. However, how microgravity affects the characteristics MSCs and the related roles in [...] Read more.

Weightlessness in space leads to bone loss, muscle atrophy, and impaired immune defense in astronauts. Mesenchymal stem cells (MSCs) play crucial roles in maintaining the homeostasis and function of the tissue. However, how microgravity affects the characteristics MSCs and the related roles in the pathophysiological changes in astronauts remain barely known. Here we used a 2D-clinostat device to simulate microgravity. Senescence-associated-β-galactosidase (SA-β-gal) staining and the expression of senescent markers p16, p21, and p53 were used to evaluate the senescence of MSCs. Mitochondrial membrane potential (mΔΨm), reactive oxygen species (ROS) production, and ATP production were used to evaluate mitochondrial function. Western blot and immunofluorescence staining were used to investigate the expression and localization of Yes-associated protein (YAP). We found that simulated microgravity (SMG) induced MSC senescence and mitochondrial dysfunction. Mito-TEMPO (MT), a mitochondrial antioxidant, restored mitochondrial function and reversed MSC senescence induced by SMG, suggesting that mitochondrial dysfunction mediates SMG-induced MSC senescence. Further, it was found that SMG promoted YAP expression and its nuclear translocation in MSCs. Verteporfin (VP), an inhibitor of YAP, restored SMG-induced mitochondrial dysfunction and senescence in MSCs by inhibiting YAP expression and nuclear localization. These findings suggest that YAP inhibition alleviates SMG-induced MSC senescence via targeting mitochondrial dysfunction, and YAP may be a potential therapeutic target for the treatment of weightlessness-related cell senescence and aging. Full article

(This article belongs to the Topic Advances in Astrobiology)

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