Organ Fibrosis: From Molecular Mechanisms to Clinical Therapies
Fibrosis is a dynamic process which is mainly characterized by an excessive accumulation of extracellular matrices. Fibrosis generally occurs as an uncontrolled wound-healing response to multiple and chronic injuries. It induces the alteration of organ architecture and leads to loss of organ function. Fibrosis is a pathology that affects several organs, such as the kidney, lungs, liver, skin, peritoneum, and heart. In addition, even if the main source of the extracellular matrix is activated by myofibroblasts, many cell types modulate the phenomenon (epithelial and mesothelial cells, endothelial cells, pericytes, vascular smooth muscle cells, inflammatory cells, and mesenchymal stem cells). Commonly, the fibrotic process is initiated by parenchymal damage, followed by unsolved inflammation; thus, some molecular mechanisms at the origin of fibrosis are shared by different organs. In this scenario, additional tissue-specific mechanisms are responsible for fibrosis. Keeping in mind that in certain situations, fibrosis could be a reversible process, deeper knowledge of its foundation is highly necessary in order to develop new therapeutic strategies. The aim of this Topic is to report new findings that advance knowledge of the molecular mechanisms and clinical therapies of organ fibrosis. We welcome submissions of research papers and reviews that focus on aspects of known mechanisms/pathways/clinical therapies, such as epithelial–mesenchymal transition, TGF-beta signaling, myofibroblast activation, proliferation, and senescence, but also manuscripts that explore new aspects.
Dr. Maurizio Onisto
Dr. Valentina Masola
- organ fibrosis
- epithelial–mesenchymal transition
- TGF-beta signaling
- myofibroblast activation
|Journal Name||Impact Factor||CiteScore||Launched Year||First Decision (median)||APC|
|4.2||4.0||2012||18.8 Days||CHF 2700|
|5.5||8.3||2011||19.2 Days||CHF 2700|
|6.0||9.0||2012||18.8 Days||CHF 2700|
Journal of Clinical Medicinejcm
|3.9||5.4||2012||19.7 Days||CHF 2600|
|-||-||2022||15.0 days *||CHF 1000|
* Median value for all MDPI journals in the first half of 2023.
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