Pharmacokinetic and Pharmacodynamic Modelling in Drug Discovery and Development
Pharmacometrics represents a valuable methodology to increase the efficiency of the drug discovery, development and use of medicines. The three basic pillars of Pharmacometrics are the thorough and detailed understanding of the disease and the drug, the development of mathematical models able to integrate information from different sources (in vitro, in vivo and in silico) and the ability to apply these strategies during the drug development process, regulatory review and clinical use. This Topic aims to highlight the role of pharmacometrics at the preclinical and clinical level, focusing on new modeling strategies and methodologies, characterizing the PK or PK/PD properties of drugs together with placebo and disease models, and optimizing dosing schedules in special sub-groups of populations in order to identify new therapeutic agents/targets and/or understanding of complex biological systems.
Prof. Dr. Inaki F. Troconiz
Dr. Victor Mangas Sanjuán
Dr. Maria Garcia-Cremades Mira
- physiologically based pharmacokinetic
- population approach
- therapeutic drug monitoring
|First Decision (median)
Journal of Personalized Medicine
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